A 32-year-old woman, gravida 2, para 1, at 14-weeks' gestation comes to the physician for a prenatal visit. Routine first trimester screening shows increased nuchal translucency, decreased β-hCG concentration, and decreased levels of pregnancy-associated plasma protein A. Amniocentesis shows trisomy of chromosome 13. This fetus is at increased risk for which of the following?
ADuodenal atresia
BCutis aplasia
CCystic hygroma
DOptic glioma
EProminent occiput
A 37-year-old woman presents for prenatal counseling at 18 weeks gestation. The patient tells you that her sister recently had a child with Down's syndrome, and the patient would like prenatal screening for Down's in her current pregnancy. Which of the following prenatal screening tests and results would raise concern for Down's syndrome?
AIncreased AFP, normal HCG, normal unconjugated estriol
BDecreased AFP, decreased HCG, decreased unconjugated estriol
CNormal AFP, increased HCG, decreased unconjugated estriol
DNormal AFP, decreased HCG, decreased unconjugated estriol
EDecreased AFP, increased HCG, decreased unconjugated estriol
A 23-year-old pregnant woman (gravida 1, para 0) presents during her 16th week of pregnancy for a check-up. The course of her current pregnancy is unremarkable. She had normal results on the previous ultrasound examination. Her human chorionic gonadotropin (hCG) level measured at week 12 of pregnancy was 0.9 multiples of the normal median (MoM). She is human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)-negative. She undergoes a quadruple test which shows the following results: Serum alpha-fetoprotein Low Unconjugated estriol Low Beta-hCG High Inhibin A High The risk of which condition indicates these results?
ATrisomy 21
BTrisomy 18
CNeural tube defect
DCongenital toxoplasmosis
ETrophoblastic disease
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