A 24-year-old man is brought to the physician because of increasing pain and swelling of the left knee for 2 months. The pain has awoken him from his sleep on multiple occasions. He tried ibuprofen but has had no relief of his symptoms. There is no family or personal history of serious illness. Vital signs are within normal limits. On examination, the left knee is mildly swollen and tender; range of motion is limited by pain. An x-ray of the left knee is shown. Which of the following is the most likely diagnosis?
AAneurysmal bone cyst
BChondrosarcoma
CEwing sarcoma
DOsteoclastoma
EFibrous dysplasia
A 17-year-old boy is brought to the physician because of progressive right knee pain for the past 3 months. He reports that the pain is worse at night and while doing sports at school. He has not had any trauma to the knee or any previous problems with his joints. His vital signs are within normal limits. Examination of the right knee shows mild swelling and tenderness without warmth or erythema; the range of motion is limited. He walks with an antalgic gait. Laboratory studies show an alkaline phosphatase of 180 U/L and an erythrocyte sedimentation rate of 80 mm/h. An x-ray of the right knee is shown. Which of the following is the most likely diagnosis?
AChordoma
BChondrosarcoma
COsteosarcoma
DOsteochondroma
EEwing sarcoma
A 55-year-old male presents to his primary care physician complaining of right hip pain for the past eight months. He also reports progressive loss of hearing over the same time period. Radiographic imaging reveals multiple areas of expanded bony cortices and coarsened trabeculae in his right hip and skull. Laboratory analysis reveals an isolated elevation in alkaline phosphatase with normal levels of serum calcium and phosphate. Which of the following histologic findings is most likely to be seen if one of the lesions were biopsied?
AMature lamellar bone with collagen fibers arranged in lamellae
BImmature woven bone with collagen fibers arranged irregularly
CChondroblasts and chondrocytes forming a cartilaginous matrix
DSheets of monotonous round blue cells
ELarge pleomorphic cells with numerous atypical mitotic figures and “lacey” osteoid formation
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