A 47-year-old woman comes to the physician because of progressive pain and stiffness in her hands and wrists for the past several months. Her hands are stiff in the morning; the stiffness improves as she starts her chores. Physical examination shows bilateral swelling and tenderness of the wrists, metacarpophalangeal joints, and proximal interphalangeal joints. Her range of motion is limited by pain. Laboratory studies show an increased erythrocyte sedimentation rate. This patient's condition is most likely associated with which of the following findings?
AIgM antibodies against the Fc region of IgG
BHLA-B27 protein on white blood cells
CHLA-A3 proteins on white blood cells
DHLA-DQ2 proteins on white blood cells
EIgG antibodies with a TNF-α binding domain on the Fc region
A 47-year-old woman comes to the physician because of body aches for the past 9 months. She also has stiffness of the shoulders and knees that is worse in the morning and tingling in the upper extremities. Examination shows marked tenderness over the posterior neck, bilateral mid trapezius, and medial aspect of the left knee. A complete blood count and erythrocyte sedimentation rate are within the reference ranges. Which of the following is the most likely diagnosis?
ASystemic lupus erythematosus
BFibromyalgia
CRheumatoid arthritis
DPolymyositis
EMajor depressive disorder
A 25-year-old woman presents into the clinic complaining of worsening malaise, hair loss, and a rash on her face. The patient states that she has been avoiding daylight because the rash becomes painful, and she has not been able to go to classes because of debilitating arthralgia in her fingers and ankles. No significant past medical history. She takes no medication. At the time of the consult, the patient has a fever of 39.0°C (102.2 °F). The presence of which of the following is most commonly seen on diagnostic labs in this patient’s most likely condition?
AAnti-smith antibody
BAnti-dsDNA
CAnti-Ro antibody
DAntinuclear antibody
EAnti-histone antibody
+ 7 more in the PDF
Browse all chapters