A 69-year-old Caucasian man presents for a routine health maintenance examination. He feels well. He has no significant past medical history. He takes aspirin for the occasional headaches that he has had for over several years. He exercises every day and does not smoke. His father was diagnosed with a hematologic malignancy at 79 years old. The patient’s vital signs are within normal limits. Physical examination shows no abnormalities. The laboratory test results are as follows: Hemoglobin 14.5 g/dL Leukocyte count 62,000/mm3 Platelet count 350,000/mm3 A peripheral blood smear is obtained (shown on the image). Which of the following best explains these findings?
AAcute lymphoid leukemia
BHairy cell leukemia
CAdult T cell leukemia
DChronic lymphocytic leukemia
EAcute myeloid leukemia
A 55-year-old man presents with severe fatigue and fever. His past medical history is significant for a recent history of mononucleosis from which he fully recovered 8 weeks ago. On physical examination, the patient seems pale. A chest radiograph shows multiple enlarged mediastinal lymph nodes. A biopsy of one of the enlarged mediastinal lymph nodes is performed and shows the presence of multinucleated cells with an 'owl-eye' appearance in a hypocellular background. Which of the following is the most likely diagnosis in this patient?
AExtranodal marginal zone lymphoma
BClassical Hodgkin lymphoma
CDiffuse large B cell lymphoma
DNodular lymphocyte-predominant lymphoma
EFollicular lymphoma
A medical research study is beginning to evaluate the positive predictive value of a novel blood test for non-Hodgkin’s lymphoma. The diagnostic arm contains 700 patients with NHL, of which 400 tested positive for the novel blood test. In the control arm, 700 age-matched control patients are enrolled and 0 are found positive for the novel test. What is the PPV of this test?
A400 / (400 + 0)
B700 / (700 + 300)
C400 / (400 + 300)
D700 / (700 + 0)
E700 / (400 + 400)
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