A 37-year-old man presents to his primary care physician because he has had constipation for the last several weeks. He has also been feeling lethargic and complains that this winter has been particularly cold. He also complains that he has been gaining weight despite no change in his normal activities. He reveals that two months prior to presentation he had what felt like the flu for which he took Tylenol and did not seek medical attention. Several days after this he developed anterior neck pain. Which of the following findings would most likely be seen on biopsy of this patient's abnormality?
AFocal hyperplasia
BGerminal follicles
CScalloped clear areas
DFibrous tissue
EGranulomatous inflammation
A 42-year-old man is referred for an endocrinology consult because of decreased triiodothyronine (T3) hormone levels. He presented to the emergency department 1 week prior to this consultation with pneumonia and was admitted to a medicine service for management of his infection. He has since recovered from his infection after intravenous antibiotic administration. He currently has no symptoms and denies feeling cold or lethargic. A panel of laboratory tests are obtained with the following results: Thyroid-stimulating hormone: 4.7 µU/mL Thyroxine (T4): 6 µg/dL Triiodothyronine (T3): 68 ng/dL Which of the following additional findings would most likely also be seen in this patient?
AIncreased free T3 concentration
BIncreased reverse T3 concentration
CDecreased free T3 concentration
DNormal free and reverse T3 concentration
EDecreased reverse T3 concentration
A 39-year-old female presents to the clinic with the complaints of dry skin for a few months. She adds that she also has constipation for which she started eating vegetables and fruits but with no improvement. She lives with her husband and children who often complain when she turns the air conditioning to high as she cannot tolerate low temperatures. She has gained 5 kgs (11.2 lb) since her last visit 2 months back although her diet has not changed much. Her past medical history is relevant for cardiac arrhythmias and diabetes. She is on several medications currently. Her temperature is 98.6° F (37° C), respirations are 15/min, pulse is 57/min and blood pressure is 132/98 mm Hg. A physical examination is within normal limits. Thyroid function test results are given below: Serum TSH: 13.0 μU/mL Thyroxine (T4): 3.0 μg/dL Triiodothyronine (T3): 100 ng/dL Which of the following medications is most likely to be responsible for her symptoms?
AAmiodarone
BDigoxin
CMetformin
DTheophylline
EWarfarin
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