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A 71-year-old man comes to the emergency department because of a 2-month history of severe muscle cramps and back pain. He says that he is homeless and has not visited a physician in the past 20 years. He is 183 cm (6 ft 0 in) tall and weighs 62 kg (137 lb); BMI is 18.5 kg/m2. His blood pressure is 154/88 mm Hg. Physical examination shows pallor, multiple cutaneous excoriations, and decreased sensation over the lower extremities. Serum studies show: Calcium 7.2 mg/dL Phosphorus 5.1 mg/dL Glucose 221 mg/dL Creatinine 4.5 mg/dL An x-ray of the spine shows alternating sclerotic and radiolucent bands in the lumbar and thoracic vertebral bodies. Which of the following is the most likely explanation for these findings?

A 1-year-old boy presents to pediatrics clinic for a well-child visit. He has no complaints. He has a cleft palate and an abnormal facial appearance. He has been riddled with recurrent infections and is followed by cardiology for a ventricular septal defect (VSD). Vital signs are stable, and the patient's physical exam is benign. If this patient's medical history is part of a larger syndrome, what might one also discover that is consistent with the manifestations of this syndrome?