A 27-year-old G1P0 at 12 weeks estimated gestational age presents for prenatal care. The patient says she has occasional nausea and vomiting and a few episodes of palpitations and diarrhea this last week. Physical examination is unremarkable, except for a heart rate of 145/min. Basic thyroid function tests are shown in the table below. Which of the following additional laboratory tests would be most useful in assessing this patient's condition? Thyroid-stimulating hormone (TSH) 0.28 mIU/L (0.3–4.5 mIU/L) Total T4 12 µg/dL (5.4–11.5 µg/dL)
AThyrotropin receptor antibodies (TRAb)
BTotal triiodothyronine (T3) levels
CThyroid peroxidase (TPO) antibodies
DFree thyroxine (T4) levels
EThyroxine-binding globulin (TBG) levels
A 25-year-old pregnant woman at 28 weeks gestation presents with a headache. Her pregnancy has been managed by a nurse practitioner. Her temperature is 99.0°F (37.2°C), blood pressure is 164/104 mmHg, pulse is 100/min, respirations are 22/min, and oxygen saturation is 98% on room air. Physical exam is notable for a comfortable appearing woman with a gravid uterus. Laboratory tests are ordered as seen below. Hemoglobin: 12 g/dL Hematocrit: 36% Leukocyte count: 6,700/mm^3 with normal differential Platelet count: 100,500/mm^3 Serum: Na+: 141 mEq/L Cl-: 101 mEq/L K+: 4.4 mEq/L HCO3-: 25 mEq/L BUN: 21 mg/dL Glucose: 99 mg/dL Creatinine: 1.0 mg/dL AST: 32 U/L ALT: 30 U/L Urine: Color: Amber Protein: Positive Blood: Negative Which of the following is the most likely diagnosis?
AHELLP syndrome
BAcute fatty liver disease of pregnancy
CPreeclampsia
DSevere preeclampsia
EEclampsia
A 30-year-old woman presents for pregnancy counseling. She says she has an 8-week history of chronic diarrhea. She is also found to be intolerant to heat and has been significantly losing her hair. She denies any recent changes to her diet. The patient is afebrile and her vital signs are within normal limits. Her weight today is 45.0 kg (99.2 lb) which is 4.5 kg (10 lb) less than her weight during her last visit 2 months back. On physical examination, the patient is anxious and has a non-intention tremor. Significant exophthalmos is present. Laboratory findings are significant for a low TSH, elevated free T4 and free T3, and a positive thyroid stimulating immunoglobulin assay. She still wants to conceive a baby and asks for an appropriate treatment that is safe in pregnancy. Which of the following best describes the therapy she will most likely receive during her pregnancy for her thyroid disorder?
ABeta-blockers
BThyroidectomy and thyroid replacement
CPlasmapheresis
DRadiation
EAntithyroid drugs (thionamides)
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