A 76-year-old woman is brought to the physician because of lesions on her left arm. She first noticed them 3 months ago and they have grown larger since that time. She has not had any pain or pruritus in the area. She has a history of invasive ductal carcinoma of the left breast, which was treated with mastectomy and radiation therapy 27 years ago. Since that time, she has had lymphedema of the left arm. Physical examination shows extensive edema of the left arm. There are four coalescing, firm, purple-blue nodules on the left lateral axillary region and swelling of the surrounding skin. Which of the following is the most likely diagnosis?
AThrombophlebitis
BCellulitis
CMelanoma
DAngiosarcoma
EKaposi sarcoma
A 62-year-old man comes to the physician for a 1-month history of fever, malaise, and skin rash. He has had a 5-kg (11-lb) weight loss during this period. He does not smoke, drink alcohol, or use illicit drugs. He appears pale. His temperature is 39.1°C (102.3°F), pulse is 110/min, and blood pressure is 140/85 mm Hg. Physical examination shows nontender, erythematous macules on the palms and soles. A photograph of one of his fingernails is shown. Microscopic examination of the nail lesion is most likely to show which of the following?
AArteriovenous malformations
BAschoff granulomas
CMicroemboli
DIgE immune complexes
ENon-caseating granulomas
A 42-year-old woman presents because of a painful mass she first noticed on her neck 1 week ago (see image). The mass has grown over the last few days. She has no history of serious illness and takes no medications. On physical exam, her temperature is 38.0°C (100.4°F), pulse is 86/min, respirations are 12/min, blood pressure is 135/80 mm Hg. The mass is tender and relatively soft and mobile. The overlying skin is warm. On her right ear, there is a series of small and healing skin punctures left by the bite of her neighbor's kitten 3 weeks ago. No other mass is detected in the neck, supraclavicular, axillary, or inguinal regions. Oral examination reveals several discolored teeth. Her lungs are clear to auscultation and heart sounds are normal. A biopsy of the neck mass is performed. Which of the following would be most useful in establishing the diagnosis?
AHistologic evaluation for Reed-Sternburg cells
BThe Monospot test for Epstein-Barr virus
CToxoplasma IgG using enzyme-linked immunosorbent assay
DCulture for facultative anaerobes
EWarthin-Starry silver stain for Bartonella henselae
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