Chapter·MicrobiologyMicrobial genetics and drug resistance

Biofilm-associated resistanceDownloads

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Sample Questions

1

A 37-year-old woman with a history of anorectal abscesses complains of pain in the perianal region. Physical examination reveals mild swelling, tenderness, and erythema of the perianal skin. She is prescribed oral ampicillin and asked to return for follow-up. Two days later, the patient presents with a high-grade fever, syncope, and increased swelling. Which of the following would be the most common mechanism of resistance leading to the failure of antibiotic therapy in this patient?

AIntrinsic absence of a target site for the drug

BUse of an altered metabolic pathway

CProduction of beta-lactamase enzyme

DAltered structural target for the drug

EDrug efflux pump

2

Part of the success of the Streptococcus pyogenes bacterium lies in its ability to evade phagocytosis. Which of the following helps in this evasion?

AStreptolysin S

BStreptolysin O

CStreptokinase

DM protein

EPyrogenic toxin

3

An investigator is studying the growth of an organism in different media. The organism is inoculated on a petri dish that contains heated sheep blood, vancomycin, nystatin, trimethoprim, and colistin. The resulting growth medium is incubated at 37°C. Numerous small, white colonies are seen after incubation for 48 hours. This organism is most likely to cause which of the following conditions?

APontiac fever

BPseudomembranous colitis

CHemolytic uremic syndrome

DOral thrush

EGonorrhea

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