A 7-year-old boy is brought to the physician because of a 5-day history of fever, malaise, and joint pain. He had a sore throat 4 weeks ago that resolved without treatment. His temperature is 38.6°C (101.5°F) and blood pressure is 84/62 mm Hg. Physical examination shows several firm, painless nodules under the skin near his elbows and the dorsal aspect of both wrists. Cardiopulmonary examination shows bilateral basilar crackles and a blowing, holosystolic murmur heard best at the cardiac apex. Both knee joints are warm. Laboratory studies show an erythrocyte sedimentation rate of 129 mm/h. The immune response seen in this patient is most likely due to the presence of which of the following?
AM protein
BCAMP factor
CTSST-1
DIgA protease
EHyaluronic acid capsule
Physical exam of a 15-year-old female reveals impetigo around her mouth. A sample of the pus is taken and cultured. Growth reveals gram-positive cocci in chains that are bacitracin sensitive. Which of the following symptoms would be concerning for a serious sequela of this skin infection?
AMyocarditis
BJoint swelling
CFever
DChorea
EHematuria
A 15-year-old boy is brought to the office by his mother with complaints of facial puffiness and smoky urine. The mother noticed puffiness on her son’s face a week ago, and it has been progressively worsening since then. She also states that her son had a sore throat 3 weeks ago. The patient does not have fever/chills, changes in urinary frequency, or abdominal discomfort. On physical examination, facial edema is noted. The vital signs include: blood pressure 145/85 mm Hg, pulse 96/min, temperature 36.7°C (98.1°F), and respiratory rate 20/min. A complete blood count report shows: Hemoglobin 10.1 g/dL RBC 4.9 million cells/µL Hematocrit 46% Total leukocyte count 6,800 cells/µL Neutrophils 70% Lymphocytes 26% Monocytes 3% Eosinophil 1% Basophils 0% Platelets 210,000 cells/µL ESR 18 mm (1st hour) Urinalysis shows: pH 6.4 Color dark brown RBC plenty WBC 3–4/HPF Protein absent Cast RBC and granular casts Glucose absent Crystal none Ketone absent Nitrite absent Which of the following laboratory findings can be expected in this patient?
AIncreased C3 level
BPositive streptozyme test
CNormal erythrocyte sedimentation rate
DDecreased serum creatinine
ENegative antistreptolysin O (ASO) titer
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