Two separate investigators have conducted cohort studies to calculate the risk of lymphoma in rheumatoid arthritis patients taking anti-TNF alpha medications. They each followed patients with rheumatoid arthritis for a number of years and tracked the number of patients who were diagnosed with lymphoma. The results of the two studies are summarized in the table. Number of patients Follow-up period Number of new cases of lymphoma Study 1 3000 10 years 30 Study 2 300 30 years 9 Based on these results, which of the following statements about the risk of lymphoma is most accurate?
AThe risk is higher in study 1, with an incidence rate of 30 cases per 10 person-years
BThe risks are equivalent, with a prevalence of 39 cases per 3300 persons
CThe risks are equivalent, with an incidence rate of 1 case per 1000 person-years
DThe risk is higher in study 1, with a prevalence of 30 cases per 3000 patients
EThe risk is higher in study 2, with a cumulative incidence of 9 cases per 300 patients
A 33-year-old woman with a history of multiple sclerosis is brought to the physician because of dizziness, urinary incontinence, loss of vision in her right eye, and numbness and weakness of the left leg. She has had recurrent episodes of neurological symptoms despite several changes in her medication regimen. An MRI of the brain shows several new enhancing lesions in the periventricular white matter and the brainstem. Treatment with a drug that binds to CD52 is initiated. Which of the following agents was most likely prescribed?
AAlemtuzumab
BEculizumab
CAbciximab
DRituximab
EBevacizumab
A 34-year-old male comes to his family physician with complaints of joint pain that has been present for over 7 weeks. Prior to the onset of his arthritis, he recalls having a gastrointestinal infection which caused mild diarrhea and abdominal cramps. He recovered well and had no issues until his joint pain started. A prescription for naproxen was previously prescribed but he still does not feel well. He has no significant past medical or family history. On physical examination, his blood pressure is 120/78 mm Hg, respirations are 17/min, pulse is 64/min, and temperature is 36.7°C (98.0°F). Which of the following therapies is likely to be most beneficial in treating this patient’s condition?
AKetoprofen
BCeftriaxone
CSulfasalazine
DMethotrexate
EDiclofenac
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