Chapter·DiagnosisRed flags

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1

A 25-year-old pregnant woman at 28 weeks gestation presents with a headache. Her pregnancy has been managed by a nurse practitioner. Her temperature is 99.0°F (37.2°C), blood pressure is 164/104 mmHg, pulse is 100/min, respirations are 22/min, and oxygen saturation is 98% on room air. Physical exam is notable for a comfortable appearing woman with a gravid uterus. Laboratory tests are ordered as seen below. Hemoglobin: 12 g/dL Hematocrit: 36% Leukocyte count: 6,700/mm^3 with normal differential Platelet count: 100,500/mm^3 Serum: Na+: 141 mEq/L Cl-: 101 mEq/L K+: 4.4 mEq/L HCO3-: 25 mEq/L BUN: 21 mg/dL Glucose: 99 mg/dL Creatinine: 1.0 mg/dL AST: 32 U/L ALT: 30 U/L Urine: Color: Amber Protein: Positive Blood: Negative Which of the following is the most likely diagnosis?

AHELLP syndrome

BAcute fatty liver disease of pregnancy

CPreeclampsia

DSevere preeclampsia

EEclampsia

2

A 25-year-old primigravida woman at 35 weeks estimated gestational age presents with a headache for the past 5 hours. She describes the headache as severe and incapacitating and showing no response to acetaminophen. In the emergency department, her blood pressure is found to be 150/100 mm Hg, pulse is 88/min, respiratory rate is 30/min, and temperature is 37.0°C (98.6°F). Her records show that her blood pressure was the same yesterday during her regular antenatal visit. Chest auscultation reveals bilateral crackles along the lung base. Abdominal examination reveals a gravid uterus consistent with a gestational age of 32 weeks and a floating fetus in a cephalic presentation. Pelvic examination is performed which shows a closed firm cervix with no evidence of bleeding or discharge. Moderate pitting edema is noted and neurologic examination shows generalized hyperreflexia. Laboratory findings are significant for the following: Hemoglobin 12.5 g/dL Platelets 185,000/μL Serum creatinine 0.4 mg/dL Spot urine creatinine 110 mg/dL Spot urine protein 360 mg/dL AST 40 IU/L Which of the following is the most likely diagnosis in this patient?

AGestational hypertension

BEclampsia

CPreeclampsia without severe features

DHELLP syndrome

EPreeclampsia with severe features

3

A 28-year-old woman, gravida 2, para 1, at 30 weeks' gestation comes to the physician because of headache for the past 5 days. Her pregnancy has been uncomplicated to date. Pregnancy and vaginal delivery of her first child were uncomplicated. The patient does not smoke or drink alcohol. She does not use illicit drugs. Medications include folic acid and a multivitamin. Her temperature is 37°C (98.6°F), pulse is 82/min, and blood pressure is 150/92 mm Hg. Physical examination reveals 2+ pitting edema in the lower extremities. Laboratory studies show: Hemoglobin 11.8 g/dL Platelet count 290,000/mm3 Urine pH 6.3 Protein 2+ WBC negative Bacteria occasional Nitrites negative The patient is at increased risk of developing which of the following complications?

AAbruptio placentae

BPolyhydramnios

CUterine rupture

DSpontaneous abortion

EPlacenta previa

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