Chapter·BiostatisticsStudy Design

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1

An investigator is measuring the blood calcium level in a sample of female cross country runners and a control group of sedentary females. If she would like to compare the means of the two groups, which statistical test should she use?

AChi-square test

BLinear regression

Ct-test

DANOVA (Analysis of Variance)

EF-test

2

A research group wants to assess the safety and toxicity profile of a new drug. A clinical trial is conducted with 20 volunteers to estimate the maximum tolerated dose and monitor the apparent toxicity of the drug. The study design is best described as which of the following phases of a clinical trial?

APhase 0

BPhase III

CPhase V

DPhase II

EPhase I

3

A student health coordinator plans on leading a campus-wide HIV screening program that will be free for the entire undergraduate student body. The goal is to capture as many correct HIV diagnoses as possible with the fewest false positives. The coordinator consults with the hospital to see which tests are available to use for this program. Test A has a sensitivity of 0.92 and a specificity of 0.99. Test B has a sensitivity of 0.95 and a specificity of 0.96. Test C has a sensitivity of 0.98 and a specificity of 0.93. Which of the following testing schemes should the coordinator pursue?

ATest A on the entire student body followed by Test B on those who are positive

BTest A on the entire student body followed by Test C on those who are positive

CTest C on the entire student body followed by Test B on those who are positive

DTest C on the entire student body followed by Test A on those who are positive

ETest B on the entire student body followed by Test A on those who are positive

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