A group of researchers is studying molecules and DNA segments that are critical for important cellular processes in eukaryotic cells. They have identified a region that is located about 28 bases upstream of the 5’ coding region. This region promotes the initiation of transcription by binding with transcription factors. Which of the following regions have these researchers most likely identified?
ATATA Box
BRNA polymerase II
CSmall nuclear ribonucleoprotein (SnRNPs)
DDNA methyltransferase
ECAAT Box
A 38-year-old man presents to his primary care practitioner for 2 months of rectal bleeding. He also reports occasional diarrhea and abdominal pain. His family history is relevant for his father and uncle, who died from complications of colorectal cancer. Colonoscopy shows more than 10 colorectal adenomas. Which of the following genes is most likely affected in this patient?
ARAS
BTP53
ChMLH1
DPPAR
EAPC
A 40-year-old man presents with an episode of rectal bleeding. He is concerned because his mother died of colorectal cancer at 50 years of age. He has no further information about his family history. Physical examination and digital rectal examination are normal. He undergoes a colonoscopy and is found to have innumerable adenomas in the left side of the colon ranging in size from 4–15 mm. Which of the following is the most likely underlying mechanism of this patient illness?
AMutation in DNA mismatch repair genes
BInactivation of RB1 gene
CAlterations in STK11 gene
DInactivation of BRCA1 and BRCA2 genes
EMutations of the APC gene
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