Which receptor type mediates the slow phase of synaptic transmission in autonomic ganglia?
AMuscarinic (M3)
BMuscarinic (M2)
CMuscarinic (M1)
DNicotinic (N2)
An investigator is studying a drug that acts on a G protein-coupled receptor in the pituitary gland. Binding of the drug to this receptor leads to increased production of inositol triphosphate (IP3) in the basophilic cells of the anterior pituitary. Administration of this drug every 90 minutes is most likely to be beneficial in the treatment of which of the following conditions?
AProstate cancer
BVariceal bleeding
CCentral diabetes insipidus
DAnovulatory infertility
EHyperkalemia
A 59-year-old man is brought to the emergency department one hour after developing shortness of breath and “squeezing” chest pain that began while he was mowing the lawn. He has asthma, hypertension, and erectile dysfunction. Current medications include salmeterol, amlodipine, lisinopril, and vardenafil. His pulse is 110/min and blood pressure is 122/70 mm Hg. Physical examination shows diaphoresis. An ECG shows sinus tachycardia. Sublingual nitroglycerin is administered. Five minutes later, his pulse is 137/min and his blood pressure is 78/40 mm Hg. Which of the following is the most likely mechanism of this patient's hypotension?
ABradykinin accumulation
BCyclic GMP elevation
CDecreased nitric oxide production
DCalcium channel antagonism
EAlpha-1 receptor antagonism
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