An investigator is studying a drug that acts on a G protein-coupled receptor in the pituitary gland. Binding of the drug to this receptor leads to increased production of inositol triphosphate (IP3) in the basophilic cells of the anterior pituitary. Administration of this drug every 90 minutes is most likely to be beneficial in the treatment of which of the following conditions?
AProstate cancer
BVariceal bleeding
CCentral diabetes insipidus
DAnovulatory infertility
EHyperkalemia
A scientist is trying to design a drug to modulate cellular metabolism in the treatment of obesity. Specifically, he is interested in understanding how fats are processed in adipocytes in response to different energy states. His target is a protein within these cells that catalyzes catabolism of an energy source. The products of this reaction are subsequently used in gluconeogenesis or β-oxidation. Which of the following is true of the most likely protein that is being studied by this scientist?
AIt is stimulated by epinephrine
BIt is inhibited by glucagon
CIt is inhibited by acetylcholine
DIt is inhibited by cortisol
EIt is stimulated by insulin
A patient with HCC and a long history of alcohol dependence and chronic hepatitis C has been using the mTOR inhibitor sirolimus 100 mg for cancer treatment. Her cancer has shown a partial response. She also has a history of hypertension and poorly controlled type 2 diabetes mellitus complicated by diabetic retinopathy. Current medications include enalapril and insulin. She asks her oncologist and hepatologist if she could try everolimus for its purported survival benefit in treating HCC. Based on clinical considerations, which of the following statements is most accurate?
AThe patient should start everolimus 50 mg because of the survival benefit relative to sirolimus 100 mg
BThe patient is not a good candidate for everolimus due to her history of hypertension
CThe patient should start everolimus 100 mg because of the survival benefit relative to sirolimus 100 mg
DThe patient should start everolimus 50 mg because of her history of alcohol use disorder and hepatitis C
EThe patient is not a good candidate for everolimus due to her history of diabetes
+ 7 more in the PDF
Browse all chapters