A patient presents to his primary care physician with complaints of regular headaches and upper abdominal pain. On physical examination, his spleen and liver seem enlarged, and his face is plethoric. Gastroendoscopy reveals several gastric ulcers ranging from 3–5 mm in greatest dimension. A bone marrow aspirate shows hypercellularity with fibrosis and serum erythropoietin is low. The patient is informed about a new treatment with ruxolitinib for the main cause of his symptoms. Which of the conditions below can develop due to the same mutation that is causing this patient's symptoms?
AAcute monocytic leukemia
BEssential thrombocythemia
CMantle cell lymphoma
DChronic myelogenous leukemia
EBurkitt's lymphoma
An investigator is studying the function of the endoplasmic reticulum in genetically modified lymphocytes. A gene is removed that facilitates the binding of ribosomes to the endoplasmic reticulum. Which of the following processes is most likely to be impaired as a result of this genetic modification?
AProduction of secretory proteins
BNeutralization of toxins
CUbiquitination of proteins
Dα-Oxidation of fatty acids
ESynthesis of ketone bodies
A 59-year-old man is brought to the physician by his wife for a psychiatric evaluation. Over the past 12 months, his behavior has become increasingly disruptive. His wife no longer brings him along shopping because he has attempted to grope a female cashier on 2 occasions. He has begun to address the mail carrier using a racial epithet. Three years later, the patient dies. Light microscopy of sections of the frontal and temporal lobes shows intracellular inclusions of transactive response DNA binding protein (TDP-43). These proteins are bound to a regulatory molecule that usually marks them for degradation. The regulatory molecule in question is most likely which of the following?
AKinesin
BChaperone
CCyclin
DUbiquitin
EClathrin
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