Chapter·BiochemistryMetabolism

Glycogen metabolismDownloads

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1

A 45-year-old man is brought to the emergency department by ambulance after vomiting blood. The patient reports that he only ate a small snack the morning before and had not eaten anything for over 24 hours. At the hospital, the patient is stabilized. He is admitted to a surgical floor and placed on NPO with a nasogastric tube set to intermittent suction. He has been previously diagnosed with liver cirrhosis. An esophagogastroduodenoscopy (EGD) has been planned for the next afternoon. At the time of endoscopy, some pathways were generating glucose to maintain serum glucose levels. Which of the following enzymes catalyzes the irreversible biochemical reaction of this process?

AGlucose-6-phosphate dehydrogenase

BGlycogen phosphorylase

CEnolase

DGlyceraldehyde-3-phosphate dehydrogenase

EFructose-1,6-bisphosphatase

2

A 24-year-old man presents for an annual check-up. He is a bodybuilder and tells you he is on a protein-rich diet that only allows for minimal carbohydrate intake. His friend suggests he try exogenous glucagon to help him lose some excess weight before an upcoming competition. Which of the following effects of glucagon is he attempting to exploit?

AIncreased glucose utilization by tissues

BDecreased blood cholesterol level

CIncreased hepatic gluconeogenesis

DIncreased lipolysis in adipose tissues

EIncreased hepatic glycogenolysis

3

A 65-year-old male prisoner goes on a hunger strike to protest the conditions of his detainment. After 5 days without food, he suffers a seizure for which he is taken into a medical facility. On physical examination, he looks pale and diaphoretic. His blood glucose level is 50 mg/dL. In order to keep a constant supply of energy to his brain, which of the following molecules is his liver releasing into the bloodstream?

AGlycogen

BGlucose-6-phosphate

Cß-hydroxybutyric acid

DFatty acids

EGlucose-1-phosphate

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