A 54-year-old man comes to the physician for a health maintenance examination. He feels well. He is 173 cm (5 ft 8 in) tall and weighs 84 kg (185 lb); BMI is 28 kg/m2. His vital signs are within normal limits. Physical examination shows no abnormalities. Serum lipid studies show: Total cholesterol 280 mg/dL HDL-cholesterol 30 mg/dL LDL-cholesterol 195 mg/dL Triglycerides 275 mg/dL Treatment with atorvastatin and cholestyramine is initiated. Which of the following changes is most likely induced by both agents?
AIncreased hepatic bile salt synthesis
BIncreased LDL receptor expression
CIncreased lipoprotein lipase activity
DDecreased hepatic de novo cholesterol synthesis
EIncreased cholesterol levels in hepatocytes
A 57-year-old presents to your clinic complaining of baldness. He is overweight, has been diagnosed with BPH, and is currently taking atorvastatin for hyperlipidemia. The patient has tried several over-the-counter products for hair-loss; however, none have been effective. After discussing several options, the patient is prescribed a medication to treat his baldness that has the additional benefit of treating symptoms of BPH as well. Synthesis of which of the following compounds would be expected to decrease in response to this therapy?
ATestosterone
BFSH
CLH
DGnRH
EDHT
An investigator is studying vitamin D metabolism in mice. He induces a gene mutation that interferes with the function of an enzyme in the renal proximal tubules that is required for vitamin D activation. He then measures serum levels of various metabolites. Production of which of the following will be impaired in this mouse?
AErgocalciferol
BCholecalciferol
C7-dehydrocholesterol
D25-hydroxyvitamin D
E1,25-dihydroxyvitamin D (calcitriol)
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