A 20-year-old male with no significant medical history comes to you with a urine positive for fructose. He does not have diabetes mellitus. Which enzyme is most likely to be deficient in this patient?
APyruvate kinase
BLactase
CFructokinase
DAldolase B
A 45-year-old woman with type 1 diabetes mellitus is brought to the emergency department by her husband because of polyuria, nausea, vomiting, and altered mental status for 4 hours. On arrival, she is unconscious. Treatment with a drug is begun that increases glucose transport to skeletal muscle and adipose tissue. Which of the following cellular events is most likely to also occur in response to this drug?
ADephosphorylation of fructose-1,6-bisphosphatase
BIncreased activity of acyl-CoA dehydrogenases
CCleavage of UDP from UDP-glucose
DUpregulation of glucose transporter type 3 expression
EPhosphorylation of glycogen phosphorylase kinase
A 12-year-old boy and his siblings are referred to a geneticist for evaluation of a mild but chronic hemolytic anemia that has presented with fatigue, splenomegaly, and scleral icterus. Coombs test is negative and blood smear does not show any abnormal findings. An enzymatic panel is assayed, and pyruvate kinase is found to be mutated on both alleles. The geneticist explains that pyruvate kinase functions in glycolysis and is involved in a classic example of feed-forward regulation. Which of the following metabolites is able to activate pyruvate kinase?
AFructose-1,6-bisphosphate
BAlanine
CATP
DGlucose-6-phosphate
EGlyceraldehyde-3-phosphate
+ 7 more in the PDF
Browse all chapters