Chapter·Behavioral ScienceSensitivity/Specificity

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Sample Questions

1

A 31-year-old woman gives birth to a boy in the labor and delivery ward of the local hospital. The child is immediately assessed and found to be crying vigorously. He is pink in appearance with blue extremities that appear to be flexed. Inducing some discomfort shows that both his arms and legs move slightly but remain largely flexed throughout. His pulse is found to be 128 beats per minute. What is the most likely APGAR score for this newborn at this time?

A8

B5

C9

D6

E7

2

An infectious disease investigator is evaluating the diagnostic accuracy of a new interferon-gamma-based assay for diagnosing tuberculosis in patients who have previously received a Bacillus Calmette-Guérin (BCG) vaccine. Consenting participants with a history of BCG vaccination received an interferon-gamma assay and were subsequently evaluated for tuberculosis by sputum culture. Results of the study are summarized in the table below. Tuberculosis, confirmed by culture No tuberculosis Total Positive interferon-gamma assay 90 6 96 Negative interferon-gamma assay 10 194 204 Total 100 200 300 Based on these results, what is the sensitivity of the interferon-gamma-based assay for the diagnosis of tuberculosis in this study?

A90/96

B100/300

C194/200

D90/100

E194/204

3

A home drug screening test kit is currently being developed. The cut-off level is initially set at 4 mg/uL, which is associated with a sensitivity of 92% and a specificity of 97%. How might the sensitivity and specificity of the test change if the cut-off level is changed to 2 mg/uL?

ASensitivity = 92%, specificity = 97%

BSensitivity = 95%, specificity = 98%

CSensitivity = 100%, specificity = 97%

DSensitivity = 90%, specificity = 99%

ESensitivity = 97%, specificity = 96%

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