A 21-year-old man comes to the physician because of painful, firm, dark bumps on his neck and jawline. He has no history of serious illness and takes no medications. His brother had a similar rash. A photograph of the rash is shown. Which of the following is the most likely underlying mechanism of this patient's condition?
ATrichophyton infection of the superficial hair follicle
BInterfollicular penetration of the skin by distal end of hair
CBacterial infection of the superficial or deep hair follicle
DFollicular obstruction with subsequent duct rupture
ECutibacterium acnes colonization of the pilosebaceous unit
A 65-year-old man presents with a slowly growing, hyperkeratotic lesion on his right temple. The lesion has been present for approximately 8 months. He has a history of significant sun exposure. Examination reveals a 1.5 cm scaly, erythematous plaque with adherent scale. Biopsy shows atypical keratinocytes extending from the epidermis into the dermis. Which of the following is the most likely diagnosis?
AActinic keratosis
BKeratoacanthoma
CSquamous cell carcinoma
DBasal cell carcinoma
A 46-year-old woman presents to your office with oral lesions as shown in Image A. On examination, you find that her back has flaccid bullae that spread when you apply lateral pressure with your fingertips. This patient most likely has autoantibodies directed against which of the following?
AType VII collagen
BLamina densa
CHemidesmosomes
DLamina lucida
EDesmosomes
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