A male neonate is being examined by a pediatrician. His mother informs the doctor that she had a mild fever with rash, muscle pain, and swollen and tender lymph nodes during the second month of gestation. The boy was born at 39 weeks gestation via spontaneous vaginal delivery with no prenatal care. On physical examination, the neonate has normal vital signs. Retinal examination reveals the findings shown in the image. Which of the following congenital heart defects is most likely to be present in this neonate?
ADouble outlet right ventricle
BAtrial septal defect
CPatent ductus arteriosus
DVentricular septal defect
ETetralogy of Fallot
Cardiac muscle serves many necessary functions, leading to a specific structure that serves these functions. The structure highlighted is an important histology component of cardiac muscle. What would be the outcome if this structure diffusely failed to function?
AFailure of potassium channels to appropriately open to repolarize the cell
BFailure of propagation of the action potential from the conduction system
CIneffective excitation-contraction coupling due to insufficient calcium ions
DInappropriate formation of cardiac valve leaflets
EOutflow tract obstruction
A 4-year-old male is brought into your office because his mother states he has been fatigued. He has not been acting like himself and has been getting tired easily while running around and playing with other children. As of last week, he has also been complaining of being short of breath. His vitals are temperature 98.6 deg F (37.2 deg C), blood pressure 100/75 mmHg, pulse 98/min, and respirations 22/min. On exam, the patient is short of breath, and there is a holosystolic murmur with an appreciable thrill along the left sternal border. There are no other noticeable abnormalities, and the mother states that the child's prenatal course along with genetic testing was normal. What is the most likely diagnosis?
AAtrial septal defect (ASD)
BEndocardial cushion defect
CVentricular septal defect (VSD)
DPatent ductus arteriosus (PDA)
ETetralogy of Fallot
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