A male infant presented with distension of abdomen shortly after birth with delayed passage of meconium. Subsequently a full-thickness biopsy of the rectum was performed. The rectal biopsy is likely to show:
ALack of ganglion cells
BFibrosis of submucosa
CThickened muscularis propria
DHyalinization of the muscular coat
Hirschsprung disease is confirmed by ?
ARectal biopsy
BPer/Rectal examination
CRectal manometry
DX-ray abdomen
A newborn baby presented with a failure to pass meconium in the immediate postnatal period. The pediatrician also notices visible yet ineffective peristalsis, and abdominal distention. A radiological contrast enema demonstrated a narrow conical segment and a dilated proximal bowel. A diagnosis of Hirschsprung disease was made. Which of the following is a cause of the condition in the patient?
APersistence of embryonic structures in the bowel wall
BCongenital obstruction due to external factors
CFailure of migration of neural crest cells
DAbnormal peristalsis due to neural dysfunction
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