A factor that is likely to increase the duration of action of a drug that is partially metabolized by CYP3A4 in the liver is:
AChronic administration of phenobarbital with the drug
BDisplacement from tissue binding sites by another drug
CChronic administration of rifampicin
DChronic administration of cimetidine with the drug
Which of the following factors influences the duration of action of a drug?
ABioavailability
BClearance
CRate of elimination
DAll of the options
A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?
A20 liter/hr
BK is 0.0693
C0.22 L/hr
D0.02 L/hr
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