A patient given digoxin started having side effects like nausea and vomiting. The serum concentration of digoxin was 4 ng/mL. The plasma therapeutic range is 1-2 ng/mL. If the half-life of digoxin is 40 hours, how long should one wait before resuming the treatment?
A120 hours
B140-180 hours
C1 half-life (40 hours)
D80 hours
Which of the following statements about the biodisposition of penicillins and cephalosporins is NOT accurate?
AProcaine penicillin G is used for intramuscular injection
BNafcillin and ceftriaxone are eliminated mainly by biliary secretion
COral bioavailability is affected by lability to gastric acid
DRenal tubular reabsorption of beta-lactams is inhibited by probenecid
Which of the following is the MOST important factor determining whether a substance can be filtered at the glomerulus?
ALipid solubility of the substance
BMolecular weight of the substance
CBinding capacity to albumin
DNone of the options
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