Volume of distribution of a drug is 500 ml and target concentration of drug in blood is 5 g/L. 20% of administered drug is reached to systemic circulation. What will be the loading dose of that drug -
A1 gm
B5 gm
C25 gm
D12.5 gm
A 70 kg man was given a drug with a dose of 100 mg/kg body weight, twice daily. The half-life (t1/2) is 10 hours, the plasma concentration is 1.9 mg/mL, and the clearance is unknown. What is the clearance of this drug?
A20 liter/hr
BK is 0.0693
C0.22 L/hr
D0.02 L/hr
What would happen to the half-life and plasma concentration of a drug which follows first-order kinetics, if the dose is doubled?
AHalf - life and plasma concentration remains the same
BHalf - life doubles and plasma concentration remains the same
CHalf - life remains the same and plasma concentration doubles
DHalf - life and plasma concentration doubles
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