Which of the following is the most common myeloproliferative disorder?
AEssential Thrombocythemia
BPolycythemia rubra vera
CCML
DMyelofibrosis
A 45-year-old woman presents with marked splenomegaly, a leukocyte count of 300,000/μL, and a differential count showing a predominance of myelocytes, metamyelocytes, bands, and segmented neutrophils, along with increased basophils and platelets, without anemia. Leukocyte alkaline phosphatase is decreased. Which of the following describes a major characteristic of chronic myeloid leukemia?
AExpansion of mature B lymphocytes in lymph nodes
BLow levels of immunoglobulins (hypogammaglobulinemia)
CPresence of hairy cells with filamentous projections
DTranslocation of chromosome 9 and 22 (Philadelphia chromosome)
A 55-year-old male with fatigue and a palpable spleen is found to have a high white cell count predominantly consisting of mature lymphocytes. What is the most likely diagnosis?
AAcute lymphoblastic leukemia
BChronic lymphocytic leukemia
CMyelodysplastic syndrome (ineffective hematopoiesis and cytopenias)
DHairy cell leukemia (characterized by "hairy" appearing cells)
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