Hematological MalignanciesDownloads

A 69-year-old Caucasian man presents for a routine health maintenance examination. He feels well. He has no significant past medical history. He takes aspirin for the occasional headaches that he has had for over several years. He exercises every day and does not smoke. His father was diagnosed with a hematologic malignancy at 79 years old. The patient’s vital signs are within normal limits. Physical examination shows no abnormalities. The laboratory test results are as follows: Hemoglobin 14.5 g/dL Leukocyte count 62,000/mm3 Platelet count 350,000/mm3 A peripheral blood smear is obtained (shown on the image). Which of the following best explains these findings?

A boy presents with fever, night sweats, and neck swelling. The biopsy of swelling showed a starry sky appearance. What is the most likely genetic abnormality seen in this case?