Chapter·BiochemistryHemoglobin and Iron Metabolism

Hemoglobin Variants and HemoglobinopathiesDownloads

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Sample Questions

1

A child presents with recurrent chest infections and abdominal pain. There is a history of 1 blood transfusion in the past. On examination, he had icterus and mild splenomegaly. Electrophoresis shows increased HbA2, HbF, and S spike. What is the likely diagnosis?

AHbC disease

BSickle cell disease

CAplastic anemia

DSickle Beta Thalassemia

2

Which of the following statements is MOST accurate regarding cyanosis in methemoglobinemia?

AAlways associated with tachycardia

BCaused by increased carboxyhemoglobin levels

CDoes not improve with supplemental oxygen

DCan occur in both congenital and acquired forms of the disease.

3

In which type of hemoglobin are zeta 2 and gamma 2 chains present?

AGower I

BGower II

CPortland

DFetal hemoglobin

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