A factor that is likely to increase the duration of action of a drug that is partially metabolized by CYP3A4 in the liver is:
AChronic administration of phenobarbital with the drug
BDisplacement from tissue binding sites by another drug
CChronic administration of rifampicin
DChronic administration of cimetidine with the drug
A patient on digoxin therapy presents with atrial fibrillation and controlled ventricular rate. Upon evaluation, the patient's serum digoxin levels are elevated compared to previous values. Which of the following concomitant medications is most likely to have contributed to the enhanced digoxin toxicity?
ATriamterene
BKCL
CAtenolol
DClarithromycin
EAmiodarone
Drug X has an affinity for albumin, while drug Y has 150 times greater affinity. Which of the following statements is MOST accurate?
ADrug X will be more available in tissues
BDrug Y will be less available in tissues
CToxicity of drug Y may be influenced by multiple factors, not just its binding.
DThe free concentration of drug X in blood is higher, facilitating tissue distribution.
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