A patient with depression was given Imipramine for 2 weeks. Relatives noticed increased excitement, colorful clothes, and increased talking. What is the next step in management?
AContinue Imipramine alone
BManage with Valproate alone
CDiscontinue Imipramine and start Valproate
DAntipsychotic with Imipramine continued
Which anti-epileptic drug is most likely to cause aplastic anemia?
APhenytoin
BCarbamazepine
CLevetiracetam
DValproate
A patient on lithium therapy developed hypertension and was started on a thiazide diuretic. After a few days, he developed coarse tremors and other symptoms suggestive of lithium toxicity. What is the probable mechanism of interaction between thiazide diuretics and lithium?
AThiazide increases the tubular reabsorption of lithium
BThiazide inhibits the metabolism of lithium
CThiazides act as an add-on drug to lithium
DNone of the above
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