Chapter·MicrobiologyBioterrorism Agents

Botulinum ToxinDownloads

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Sample Questions

1

Differential diagnosis of Botulism are all except -

AMyasthenia gravis

BEaton-Lambert syndrome

CTick paralysis

DClostridial myonecrosis

EStroke syndromes

FGuillain-Barré syndrome

2

A 34-year-old woman is seen in the emergency department. About 5 hours previously, she began to have nausea, vomiting, abdominal cramps, and diarrhea. She then developed double vision, which prompted her to ask her husband to bring her to the emergency department. When she is asked to go into the examining room, she stumbles. When she tries to answer questions, her voice sounds odd and she seems to mumble. Physical examination demonstrates a dry mouth, drooping eyelids, markedly diminished pupillary light reflex, a flaccid facial expression, and difficulty in opening her mouth. Within an hour, her condition has markedly deteriorated. She can no longer stand and is intubated because of difficulty breathing. Which of the following microbial species is MOST likely to have caused her condition?

AClostridium ramosum

BClostridium perfringens

CClostridium septicum

DClostridium botulinum

3

Botulinum toxin acts on

ASynapse

BSmooth muscle of intestine

CCentral nervous system

DSensory nerves

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