Two normal, healthy subjects volunteer for a study on insulin secretion. In Patient 1, blood glucose is increased to 150 mg/dL by direct intravenous infusion. In Patient 2, blood glucose is increased to 150 mg/dL by ingestion of oral glucose. The peak plasma insulin concentration produced in Patient 1 is 70 uU/mL while in Patient 2, it is 95 uU/mL. Which of the following best explains the higher insulin concentration in Patient 2?
AIngested glucose increases duodenal secretion of gastric inhibitory peptide (GIP), increasing beta cell release of insulin
BIntravenous glucose increases islet cell secretion of somatostatin, inhibiting beta cell release of insulin
CIntravenous glucose increases islet cell secretion of glucagon, inhibiting beta cell release of insulin
DIngested glucose activates a sympathetic reflex that increases beta cell release of insulin
Best provocative test for diagnosis of Gastrinoma is:
ACa++ infusion test
BSecretin injection test
CACTH stimulation test
DSteroid assay
What is the most important site for gastrin-producing cells?
ACardia
BFundus
CAntrum
DDuodenum
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