Carboxylation of clotting factors by vitamin K is required for them to be biologically active. Which amino acid is carboxylated?
AHistidine
BSerine
CGlutamate
DAspartate
Vitamin K leads to?
Aβ-carboxylation of glutamic acid residues in clotting factors II, VII, IX, and X
Bα-carboxylation of aspartic acid residues in clotting factors II, VII, IX, and X
Cγ-carboxylation of aspartic acid residues in clotting factors II, VII, IX, and X
Dγ-carboxylation of glutamic acid residues in clotting factors II, VII, IX, and X
A 78 year old man who lives alone and prepares his own food is found to have ecchymotic patches over posterior aspect of his lower extremities. He has haemorrhagic areas around hair follicles, hair are fragmented and splinter haemorrhages are present in nail beds and several hematomas are present in the muscles of arms and legs. PT and CT are normal. This clinical syndrome is most likely due to
AVitamin A deficiency
BVitamin C deficiency
CVitamin K deficiency
DPyridoxine deficiency
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