A 55-year-old male with fatigue and a palpable spleen is found to have a high white cell count predominantly consisting of mature lymphocytes. What is the most likely diagnosis?
AAcute lymphoblastic leukemia
BChronic lymphocytic leukemia
CMyelodysplastic syndrome (ineffective hematopoiesis and cytopenias)
DHairy cell leukemia (characterized by "hairy" appearing cells)
What is the cell of origin of B-cell Acute Lymphoblastic Leukemia (B-ALL)?
AT cells
BImmature B cells
CImmature T cells
DBoth T & B cells
In the context of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), which of the following cytogenetic abnormalities is associated with the worst prognosis?
Ainv(16)
BNormal cytogenetics
CMonosomy 7
Dt(8;21) translocation
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