A patient given digoxin started having side effects like nausea and vomiting. The serum concentration of digoxin was 4 ng/mL. The plasma therapeutic range is 1-2 ng/mL. If the half-life of digoxin is 40 hours, how long should one wait before resuming the treatment?
A120 hours
B140-180 hours
C1 half-life (40 hours)
D80 hours
Variation in sensitivity of response to different doses of a drug in different individuals is obtained from?
ADose-response relationship
BTherapeutic index
CBioavailability
DPhase 1 clinical trials
A patient on digoxin therapy presents with atrial fibrillation and controlled ventricular rate. Upon evaluation, the patient's serum digoxin levels are elevated compared to previous values. Which of the following concomitant medications is most likely to have contributed to the enhanced digoxin toxicity?
ATriamterene
BKCL
CAtenolol
DClarithromycin
EAmiodarone
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