Which of the following statements is true regarding competitive reversible antagonism?
AED50 remains unchanged in competitive reversible antagonism.
BEfficacy and Vmax remain unchanged.
CPotency remains unchanged in the presence of a competitive antagonist.
DAffinity (Kd) remains unchanged in competitive reversible antagonism.
Volume of distribution of a drug is 500 ml and target concentration of drug in blood is 5 g/L. 20% of administered drug is reached to systemic circulation. What will be the loading dose of that drug -
A1 gm
B5 gm
C25 gm
D12.5 gm
A patient named Ram Prasad is admitted to Guru Teg Bahadur Hospital with a respiratory infection. Tobramycin is ordered for treatment. Given that the clearance and volume of distribution of tobramycin in him are 160 mL/min and 40 L, respectively, calculate the intravenous loading dose required to achieve a therapeutic plasma concentration of 4 mg/L.
A0.1 mg
B10 mg
C115.2 mg
D160 mg
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