What is the mechanism of metabolism for alcohol, aspirin, and phenytoin at high doses?
AFirst pass kinetics
BFirst order kinetics
CZero order kinetics
DSecond order kinetics
A factor that is likely to increase the duration of action of a drug that is partially metabolized by CYP3A4 in the liver is:
AChronic administration of phenobarbital with the drug
BDisplacement from tissue binding sites by another drug
CChronic administration of rifampicin
DChronic administration of cimetidine with the drug
Phase 1 biotransformation includes
AReduction
BMethylation
CAcetylation
DSulfate conjugation
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