A 35-year-old man suffers severe polytrauma including traumatic brain injury (GCS 6), pulmonary contusions, splenic laceration, and open femur fracture. He undergoes damage control surgery with splenectomy and external fixation. On ICU day 4, he develops worsening hypoxemia (PaO2/FiO2 ratio 150), bilateral infiltrates on chest X-ray, normal pulmonary capillary wedge pressure, petechiae, and altered mental status beyond his head injury. Fat globules are noted in urine. Platelet count drops from 245,000 to 89,000/μL. Evaluate the diagnosis and management priority.
Postoperative bleeding
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Surgical site infections
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Anastomotic leak
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Urinary complications
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Pulmonary complications
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Cardiac complications
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Thromboembolic complications
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Neurological complications
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Ileus and bowel dysfunction
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Wound complications (dehiscence, evisceration)
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Iatrogenic injuries
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Retained surgical items
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Systemic inflammatory response syndrome
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