A 46-year-old man comes to the physician with chronic abdominal pain. He has a 3-year history of severe peptic ulcer disease and esophagitis. Two months ago, he took omeprazole, clarithromycin, and amoxicillin for 14 days. His medical history is otherwise unremarkable. Currently, he takes omeprazole 60 mg/day. He is a 10 pack-year smoker and consumes alcohol regularly. Vital signs are within normal limits. Mild epigastric tenderness is noted on deep palpation of the epigastrium. Laboratory studies show:
Serum
Calcium 9.5 mg/dL
Phosphorus 4 mg/dL
An upper endoscopy shows several large ulcers in the antrum and 2nd and 3rd parts of the duodenum. The rapid urease test is negative. Fasting gastrin levels are elevated. PET-CT with Ga-Dotatate shows a single mass in the wall of the duodenum. No other mass is detected. Pituitary MRI shows no abnormality. Which of the following is the most appropriate next step in management?
Q102
A 24-year-old man comes to the emergency department because of left shoulder pain hours after suffering a fall from a height of approximately 10 feet while rock climbing about 5 hours ago. He initially thought the pain would resolve with rest but it became more severe over the last 2 hours. Last year while rock climbing he fell onto his right shoulder and “needed a sling to fix it”. He has psoriasis. His only medication is topical clobetasol. His pulse is 95/min, respiratory rate is 16/minute, and blood pressure is 114/70 mm Hg. Examination shows full passive and active range of motion at the left shoulder. There is no tenderness to palpation at the acromioclavicular joint. There are silvery plaques over both knees and elbows. Abdominal exam shows 7/10 left upper quadrant tenderness with voluntary guarding. A complete blood count and serum concentrations of electrolytes are within the reference range. Which of the following is the most appropriate next step in management?
Q103
A 45-year-old woman comes to the physician because of a 3-month history of mild right upper abdominal pain. She has not had any fevers, chills, or weight loss. There is no personal or family history of serious illness. Medications include transdermal estrogen, which she recently started taking for symptoms related to menopause. Abdominal examination shows no abnormalities. Ultrasonography of the liver shows a well-demarcated, homogeneous, hyperechoic mass surrounded by normal liver tissue. A biopsy of the lesion would put this patient at greatest risk for which of the following complications?
Q104
A 73-year-old man presents to the emergency department complaining of abdominal pain with nausea and vomiting, stating that he “can’t keep anything down”. He states that the pain has been gradually getting worse over the past 2 months, saying that, at first, it was present only an hour after he ate but now is constant. He also says that he has been constipated for the last 2 weeks, which has also been getting progressively worse. His last bowel movement was 4 days ago which was normal. He states that he cannot pass flatus. The patient’s past medical history is significant for hypertension and an episode of pneumonia last year. The patient is afebrile and his pulse is 105/min. On physical examination, the patient is uncomfortable. His lungs are clear to auscultation bilaterally. His abdomen is visibly distended and diffusely tender with tympany on percussion. A contrast CT scan of the abdomen shows dilated loops of small bowel with collapsed large bowel. Which of the following is the most likely cause of this patient’s condition?
Q105
A 74-year-old man presents to the emergency department with sudden-onset abdominal pain that is most painful around the umbilicus. The pain began 16 hours ago and has no association with meals. He has not been vomiting, but he has had several episodes of bloody loose bowel movements. He was hospitalized 1 week ago for an acute myocardial infarction. He has had diabetes mellitus for 35 years and hypertension for 20 years. He has smoked 15–20 cigarettes per day for the past 40 years. His temperature is 36.9°C (98.42°F), blood pressure is 95/65 mm Hg, and pulse is 95/min. On physical examination, the patient is in severe pain, there is mild periumbilical tenderness, and a bruit is heard over the epigastric area. Which of the following is the definitive test to assess the patient condition?
Q106
A 30-year-old woman, gravida 1, para 0, at 30 weeks' gestation is brought to the emergency department because of progressive upper abdominal pain for the past hour. The patient vomited once on her way to the hospital. She states that she initially had dull stomach pain about 6 hours ago, but now the pain is located in the upper abdomen and is more severe. There is no personal or family history of serious illness. She is sexually active with her husband. She does not smoke or drink alcohol. Medications include folic acid and a multivitamin. Her temperature is 38.5°C (101.3°F), pulse is 100/min, and blood pressure is 130/80 mm Hg. Physical examination shows right upper quadrant tenderness. The remainder of the examination shows no abnormalities. Laboratory studies show a leukocyte count of 12,000/mm3. Urinalysis shows mild pyuria. Which of the following is the most likely diagnosis?
Q107
A 54-year-old woman comes to the emergency department because of a 5-hour history of diffuse, severe abdominal pain, nausea, and vomiting. She reports that there is no blood or bile in the vomitus. Two weeks ago, she started having mild aching epigastric pain, which improved with eating. Since then, she has gained 1.4 kg (3 lb). She has a 2-year history of osteoarthritis of both knees, for which she takes ibuprofen. She drinks 1–2 glasses of wine daily. She is lying supine with her knees drawn up and avoids any movement. Her temperature is 38.5°C (101.3°F), pulse is 112/min, respirations are 20/min, and blood pressure is 115/70 mm Hg. Physical examination shows abdominal tenderness and guarding; bowel sounds are decreased. An x-ray of the chest is shown. Which of the following is the most likely cause of this patient's current symptoms?
Q108
A 63-year-old man is brought to the emergency department for evaluation of abdominal pain. The pain started four days ago and is now a diffuse crampy pain with an intensity of 6/10. The patient has nausea and has vomited twice today. His last bowel movement was three days ago. He has a history of hypertension and recurrent constipation. Five years ago, he underwent emergency laparotomy for a perforated duodenal ulcer. His father died of colorectal cancer at the age of 65 years. The patient has been smoking one pack of cigarettes daily for the past 40 years. Current medications include lisinopril and lactulose. His temperature is 37.6°C (99.7°F), pulse is 89/min, and blood pressure is 120/80 mm Hg. Abdominal examination shows distention and mild tenderness to palpation. There is no guarding or rebound tenderness. The bowel sounds are high-pitched. Digital rectal examination shows no abnormalities. An x-ray of the abdomen is shown. In addition to fluid resuscitation, which of the following is the most appropriate next step in the management of this patient?
Q109
A 67-year-old man presents to the emergency department with abdominal pain that started 1 hour ago. The patient has a past medical history of diabetes and hypertension as well as a 40 pack-year smoking history. His blood pressure is 107/58 mmHg, pulse is 130/min, respirations are 23/min, and oxygen saturation is 98% on room air. An abdominal ultrasound demonstrates focal dilation of the aorta with peri-aortic fluid. Which of the following is the best next step in management?
Q110
A 61-year-old man comes to the physician because of several episodes of dark urine over the past 2 weeks. He does not have dysuria or flank pain. He works in a factory that produces dyes. Since an accident at work 5 years ago, he has had moderate hearing loss bilaterally. He takes no medications. He has smoked a pack of cigarettes daily for 29 years and drinks one alcoholic beverage daily. Vital signs are within normal limits. Physical examination shows no abnormalities. His urine is pink; urinalysis shows 80 RBC/hpf but no WBCs. Cystoscopy shows a 3-cm mass in the bladder mucosa. The mass is resected. Pathologic examination shows an urothelial carcinoma with penetration into the muscular layer. An x-ray of the chest and a CT scan of the abdomen and pelvis with contrast show a normal upper urinary tract and normal lymph nodes. Which of the following is the most appropriate next step in management?
Abdominal emergencies US Medical PG Practice Questions and MCQs
Question 101: A 46-year-old man comes to the physician with chronic abdominal pain. He has a 3-year history of severe peptic ulcer disease and esophagitis. Two months ago, he took omeprazole, clarithromycin, and amoxicillin for 14 days. His medical history is otherwise unremarkable. Currently, he takes omeprazole 60 mg/day. He is a 10 pack-year smoker and consumes alcohol regularly. Vital signs are within normal limits. Mild epigastric tenderness is noted on deep palpation of the epigastrium. Laboratory studies show:
Serum
Calcium 9.5 mg/dL
Phosphorus 4 mg/dL
An upper endoscopy shows several large ulcers in the antrum and 2nd and 3rd parts of the duodenum. The rapid urease test is negative. Fasting gastrin levels are elevated. PET-CT with Ga-Dotatate shows a single mass in the wall of the duodenum. No other mass is detected. Pituitary MRI shows no abnormality. Which of the following is the most appropriate next step in management?
A. Quadruple therapy for Helicobacter pylori
B. Biological therapy with interferon-alpha
C. Surgical resection (Correct Answer)
D. Adjuvant therapy with octreotide
E. Smoking cessation
Explanation: ***Surgical resection***
- The patient has severe, recurrent peptic ulcer disease and esophagitis, **elevated fasting gastrin levels**, and a **single, localized duodenal mass** identified by PET-CT. These findings are highly suggestive of a **gastrinoma** (Zollinger-Ellison syndrome).
- Given the tumor is **solitary and localized** to the duodenal wall, surgical resection offers the best chance for **cure** and symptom resolution in gastrinoma.
*Quadruple therapy for Helicobacter pylori*
- The patient already received **triple therapy** for *H. pylori* 2 months prior, and the **rapid urease test is negative**, making active *H. pylori* infection unlikely to be the cause of his current severe, recurrent ulcers.
- While *H. pylori* is a common cause of ulcers, the **elevated gastrin levels** and presence of a tumor strongly point to a gastrinoma, which would not respond to *H. pylori* eradication.
*Biological therapy with interferon-alpha*
- **Interferon-alpha** is not a primary treatment for **localized gastrinoma**. It is sometimes used in certain neuroendocrine tumors, but usually in advanced, metastatic settings or as part of a multi-drug regimen, not as an initial therapy for a resectable lesion.
- The goal for a solitary, resectable gastrinoma is **surgical cure**, which is generally more effective than biological therapies in this context.
*Adjuvant therapy with octreotide*
- **Octreotide**, a somatostatin analog, can help control symptoms (e.g., acid hypersecretion) and tumor growth in some neuroendocrine tumors, including gastrinomas.
- However, for a **resectable gastrinoma**, surgical removal of the tumor offers the potential for cure, making it the more appropriate initial step over adjuvant pharmacological therapy. Octreotide might be used if surgery is not feasible or for metastatic disease.
*Smoking cessation*
- **Smoking cessation** is always beneficial for overall health and can reduce the risk of ulcer recurrence, but it does not address the underlying **gastrinoma** causing the severe, recurrent ulcers and elevated gastrin levels.
- While important for general health, it is not the most appropriate *next step* to address the specific, severe, and potentially curable pathology causing the patient's symptoms.
Question 102: A 24-year-old man comes to the emergency department because of left shoulder pain hours after suffering a fall from a height of approximately 10 feet while rock climbing about 5 hours ago. He initially thought the pain would resolve with rest but it became more severe over the last 2 hours. Last year while rock climbing he fell onto his right shoulder and “needed a sling to fix it”. He has psoriasis. His only medication is topical clobetasol. His pulse is 95/min, respiratory rate is 16/minute, and blood pressure is 114/70 mm Hg. Examination shows full passive and active range of motion at the left shoulder. There is no tenderness to palpation at the acromioclavicular joint. There are silvery plaques over both knees and elbows. Abdominal exam shows 7/10 left upper quadrant tenderness with voluntary guarding. A complete blood count and serum concentrations of electrolytes are within the reference range. Which of the following is the most appropriate next step in management?
A. Radiographs of the left shoulder
B. Abdominal ultrasound
C. MRI of the left shoulder
D. Serial vital signs for at least nine hours
E. CT scan of the abdomen (Correct Answer)
Explanation: ***CT scan of the abdomen***
- The patient's fall from a significant height (10 feet) and subsequent **left upper quadrant tenderness with voluntary guarding** are highly concerning for **splenic injury**.
- A **CT scan of the abdomen** is the most appropriate and sensitive diagnostic tool to evaluate for splenic rupture, perisplenic hematoma, or other intra-abdominal injuries in a hemodynamically stable patient following blunt abdominal trauma.
*Radiographs of the left shoulder*
- The presence of **full passive and active range of motion** and **no tenderness to palpation at the acromioclavicular joint** makes a significant acute shoulder fracture or dislocation unlikely, despite the history of previous shoulder injury.
- While imaging for the shoulder might be considered later for persistent pain, addressing the potential life-threatening abdominal injury takes immediate priority.
*Abdominal ultrasound*
- Although useful for detecting **free fluid** (FAST exam), an ultrasound may miss solid organ injuries like a small splenic laceration or subcapsular hematoma, particularly if the operator is not highly experienced or the injury is subtle.
- A **CT scan with contrast** provides more detailed anatomical information and is superior for characterizing solid organ injuries.
*MRI of the left shoulder*
- An MRI is excellent for evaluating **soft tissue injuries** like rotator cuff tears or labral tears, but it is not indicated as the initial step given the more urgent concern for intra-abdominal injury.
- Furthermore, **full range of motion** makes an acute, severe soft tissue injury less likely to be the primary concern requiring immediate high-level imaging.
*Serial vital signs for at least nine hours*
- While **serial vital signs** are crucial for monitoring a patient with potential internal bleeding or shock, relying solely on observation without immediate diagnostic imaging for suspected splenic injury is inappropriate.
- The patient is currently **hemodynamically stable** (BP 114/70, HR 95), but a splenic injury can decompensate rapidly; thus, diagnostic imaging is needed to assess the extent of injury.
Question 103: A 45-year-old woman comes to the physician because of a 3-month history of mild right upper abdominal pain. She has not had any fevers, chills, or weight loss. There is no personal or family history of serious illness. Medications include transdermal estrogen, which she recently started taking for symptoms related to menopause. Abdominal examination shows no abnormalities. Ultrasonography of the liver shows a well-demarcated, homogeneous, hyperechoic mass surrounded by normal liver tissue. A biopsy of the lesion would put this patient at greatest risk for which of the following complications?
A. Intraperitoneal hemorrhage (Correct Answer)
B. Metastatic spread
C. Anaphylactic shock
D. Bacteremia
E. Biliary peritonitis
Explanation: ***Intraperitoneal hemorrhage***
- This patient likely has a **hepatic adenoma**, given the use of **estrogen therapy** and the ultrasound findings of a **well-demarcated, homogeneous, hyperechoic mass**. Biopsy of a hepatic adenoma carries a significant risk of **hemorrhage** due to its rich vascularity and tendency for spontaneous bleeding.
- Hepatic adenomas are **benign tumors** that can rupture and cause **life-threatening intraperitoneal bleeding**, making biopsy a high-risk procedure for this specific lesion.
*Metastatic spread*
- This option is unlikely because hepatic adenomas are **benign tumors** and do not metastasize.
- The risk of biopsy spreading malignancy is negligible as the lesion is not malignant.
*Anaphylactic shock*
- Anaphylactic shock is a **severe allergic reaction** typically caused by medications, insect stings, or certain foods, which is not a direct complication of liver biopsy itself.
- While an allergic reaction to local anesthetic or contrast agents is theoretically possible, it's not the greatest risk specifically associated with biopsying a highly vascular liver lesion.
*Bacteremia*
- Bacteremia is a risk with any invasive procedure, but it is typically a concern when there is a risk of introducing bacteria, such as in a patient with a **biliary obstruction** or infected lesion.
- In this case, the patient's symptoms and ultrasound findings do not suggest an infectious process or biliary tree pathology.
*Biliary peritonitis*
- Biliary peritonitis is a risk when a biopsy tract traverses the **biliary tree**, leading to bile leakage into the peritoneal cavity.
- Given the descriptions of a **homogeneous mass** with no signs of biliary obstruction or dilation, the risk of biliary peritonitis is less prominent compared to hemorrhage in a vascular lesion like a hepatic adenoma.
Question 104: A 73-year-old man presents to the emergency department complaining of abdominal pain with nausea and vomiting, stating that he “can’t keep anything down”. He states that the pain has been gradually getting worse over the past 2 months, saying that, at first, it was present only an hour after he ate but now is constant. He also says that he has been constipated for the last 2 weeks, which has also been getting progressively worse. His last bowel movement was 4 days ago which was normal. He states that he cannot pass flatus. The patient’s past medical history is significant for hypertension and an episode of pneumonia last year. The patient is afebrile and his pulse is 105/min. On physical examination, the patient is uncomfortable. His lungs are clear to auscultation bilaterally. His abdomen is visibly distended and diffusely tender with tympany on percussion. A contrast CT scan of the abdomen shows dilated loops of small bowel with collapsed large bowel. Which of the following is the most likely cause of this patient’s condition?
A. Incarcerated hernia
B. Crohn's disease
C. Diverticulitis
D. Adhesions
E. Mass effect from a tumor (Correct Answer)
Explanation: ***Mass effect from a tumor***
- The patient's **progressive symptoms** over two months, including worsening abdominal pain initially post-prandial but now constant, progressive constipation, and inability to pass flatus, strongly suggest a **gradually developing obstruction**.
- In a **73-year-old patient**, the **progressive course** and age make **colorectal cancer** a primary concern for mechanical bowel obstruction.
- The **CT findings** of dilated small bowel loops with collapsed distal large bowel indicate a **transition point likely at the level of the distal ileum/ileocecal junction or proximal colon**, consistent with a mass causing mechanical obstruction. With a competent ileocecal valve, a proximal colonic mass can lead to retrograde small bowel dilation.
- The **gradual two-month progression** is highly characteristic of a **growing neoplasm** causing progressive luminal narrowing.
*Incarcerated hernia*
- An incarcerated hernia typically presents with more **acute and severe localized pain**, often associated with a **palpable bulge** at common hernia sites (inguinal, femoral, umbilical, or ventral).
- While it can cause small bowel obstruction, the **gradual onset and steady progression over two months** are atypical for hernia incarceration, which usually develops more acutely.
*Crohn's disease*
- Crohn's disease is characterized by **chronic transmural inflammation** of the GI tract, often presenting with recurrent abdominal pain, diarrhea, weight loss, and sometimes strictures leading to obstruction.
- However, the patient's **age (73)** with **new-onset symptoms** and **no prior inflammatory history** make Crohn's disease unlikely, as it typically presents in younger patients (teens to 30s) with a chronic relapsing-remitting course.
*Diverticulitis*
- Diverticulitis typically presents with **acute localized left lower quadrant pain**, fever, and leukocytosis due to inflammation of colonic diverticula.
- While chronic diverticulitis can lead to strictures, it would more likely cause **large bowel obstruction** rather than the small bowel dilation pattern seen here, and the **absence of fever** and **two-month progressive course** are less typical.
*Adhesions*
- Adhesions are the **most common cause of small bowel obstruction overall**, especially in patients with a **history of prior abdominal or pelvic surgery**.
- However, this patient has **no mentioned surgical history**, and adhesions typically cause **acute or intermittent obstructive episodes** rather than the **steady two-month progressive course** characteristic of a growing malignant mass.
Question 105: A 74-year-old man presents to the emergency department with sudden-onset abdominal pain that is most painful around the umbilicus. The pain began 16 hours ago and has no association with meals. He has not been vomiting, but he has had several episodes of bloody loose bowel movements. He was hospitalized 1 week ago for an acute myocardial infarction. He has had diabetes mellitus for 35 years and hypertension for 20 years. He has smoked 15–20 cigarettes per day for the past 40 years. His temperature is 36.9°C (98.42°F), blood pressure is 95/65 mm Hg, and pulse is 95/min. On physical examination, the patient is in severe pain, there is mild periumbilical tenderness, and a bruit is heard over the epigastric area. Which of the following is the definitive test to assess the patient condition?
A. CT angiography (Correct Answer)
B. Colonoscopy
C. Plain abdominal X-rays
D. Mesenteric angiography
E. Complete blood count
Explanation: ***CT angiography***
- This patient presents with symptoms highly suggestive of **acute mesenteric ischemia**, including sudden-onset severe abdominal pain disproportionate to physical exam findings ("pain out of proportion"), bloody bowel movements, and significant risk factors (recent MI, diabetes, hypertension, smoking).
- **CT angiography** is the **definitive, non-invasive diagnostic test** for mesenteric ischemia, as it can visualize the mesenteric arteries and identify occlusions or stenoses, which is crucial for guiding treatment.
*Colonoscopy*
- While suitable for evaluating causes of lower GI bleeding such as diverticulitis or colitis, it is **not the primary diagnostic tool** for acute mesenteric ischemia due to its limited ability to directly assess the arterial blood supply.
- Furthermore, in acute mesenteric ischemia, there is a risk of **bowel perforation** with colonoscopy.
*Plain abdominal X-rays*
- **Plain abdominal X-rays** are typically **non-specific** in acute mesenteric ischemia and may only show signs of advanced ischemia like pneumatosis intestinalis, which is an ominous finding.
- They are insufficient to visualize the mesenteric vasculature or pinpoint the cause of ischemia.
*Mesenteric angiography*
- **Mesenteric angiography** is an invasive procedure that can be diagnostic and therapeutic (e.g., for thrombolysis or angioplasty).
- However, in the acute setting, **CT angiography is preferred as the initial definitive diagnostic test** due to its widespread availability, speed, and non-invasiveness.
*Complete blood count*
- A **complete blood count (CBC)** can reveal signs like **leukocytosis** (elevated white blood cell count) or **hemoconcentration**, which are non-specific indicators of stress or dehydration.
- It does **not provide direct information** about the underlying cause of abdominal pain or the mesenteric vascular supply.
Question 106: A 30-year-old woman, gravida 1, para 0, at 30 weeks' gestation is brought to the emergency department because of progressive upper abdominal pain for the past hour. The patient vomited once on her way to the hospital. She states that she initially had dull stomach pain about 6 hours ago, but now the pain is located in the upper abdomen and is more severe. There is no personal or family history of serious illness. She is sexually active with her husband. She does not smoke or drink alcohol. Medications include folic acid and a multivitamin. Her temperature is 38.5°C (101.3°F), pulse is 100/min, and blood pressure is 130/80 mm Hg. Physical examination shows right upper quadrant tenderness. The remainder of the examination shows no abnormalities. Laboratory studies show a leukocyte count of 12,000/mm3. Urinalysis shows mild pyuria. Which of the following is the most likely diagnosis?
A. Pyelonephritis
B. Acute cholangitis
C. Appendicitis (Correct Answer)
D. Nephrolithiasis
E. HELLP syndrome
Explanation: ***Correct Option: Appendicitis***
- While appendicitis typically presents with right lower quadrant pain, during **pregnancy**, the **appendix can shift superiorly and laterally** due to the enlarging uterus, causing **right upper quadrant pain**.
- The combination of **progressive abdominal pain**, **fever (38.5°C)**, **leukocytosis (12,000/mm3)**, and **right upper quadrant tenderness** in a pregnant patient is highly suggestive of appendicitis in this context.
*Incorrect Option: Pyelonephritis*
- Although **fever, pyuria**, and flank pain are characteristic of pyelonephritis, the primary complaint here is **progressive upper abdominal pain** with significant tenderness in the right upper quadrant, rather than typical costovertebral angle tenderness.
- Mild pyuria alone, without other definitive urinary tract infection symptoms, does not fully explain the presentation, especially the localized severe abdominal pain and leukocytosis directly attributed to abdominal pathology.
*Incorrect Option: Acute cholangitis*
- Acute cholangitis involves **Charcot's triad (fever, jaundice, right upper quadrant pain)** and often **Reynolds' pentad (adding altered mental status and hypotension)**; jaundice is notably absent.
- While it causes right upper quadrant pain and fever, the absence of **jaundice** and often elevated liver enzymes and bilirubin makes this diagnosis less likely compared to appendicitis with an atypical presentation in pregnancy.
*Incorrect Option: Nephrolithiasis*
- **Kidney stones** typically cause **colicky flank pain** radiating to the groin, which is often severe and intermittent, and is not usually localized to the right upper quadrant in this manner.
- The presence of fever and significant leukocytosis points more towards an inflammatory or infectious process beyond simple nephrolithiasis.
*Incorrect Option: HELLP syndrome*
- **HELLP syndrome** (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a severe form of preeclampsia typically presenting with **right upper quadrant pain**, but it would also involve **hypertension often >140/90 mmHg**, proteinuria, and characteristic lab abnormalities (hemolysis, elevated liver enzymes, low platelets).
- The patient's blood pressure (130/80 mmHg) is normal, and there's no mention of specific lab findings indicative of hemolysis, liver enzyme elevation, or thrombocytopenia.
Question 107: A 54-year-old woman comes to the emergency department because of a 5-hour history of diffuse, severe abdominal pain, nausea, and vomiting. She reports that there is no blood or bile in the vomitus. Two weeks ago, she started having mild aching epigastric pain, which improved with eating. Since then, she has gained 1.4 kg (3 lb). She has a 2-year history of osteoarthritis of both knees, for which she takes ibuprofen. She drinks 1–2 glasses of wine daily. She is lying supine with her knees drawn up and avoids any movement. Her temperature is 38.5°C (101.3°F), pulse is 112/min, respirations are 20/min, and blood pressure is 115/70 mm Hg. Physical examination shows abdominal tenderness and guarding; bowel sounds are decreased. An x-ray of the chest is shown. Which of the following is the most likely cause of this patient's current symptoms?
A. Cholecystolithiasis
B. Acute mesenteric ischemia
C. Gastroesophageal reflux disease
D. Perforated peptic ulcer (Correct Answer)
E. Acute pancreatitis
Explanation: ***Perforated peptic ulcer***
- The patient's history of **epigastric pain improved with eating** (suggestive of a duodenal ulcer), daily ibuprofen use, and sudden onset of severe abdominal pain with guarding strongly points to **perforated peptic ulcer**.
- The chest x-ray showing **free air under the diaphragm** (pneumoperitoneum) is pathognomonic for a perforated viscus, most commonly a perforated peptic ulcer.
*Cholecystolithiasis*
- This typically presents with **biliary colic**, often post-prandial, or right upper quadrant pain if complicated by cholecystitis.
- While gallstones can cause severe abdominal pain, it would not typically result in **free air under the diaphragm** on a chest x-ray.
*Acute mesenteric ischemia*
- This condition presents with **severe, diffuse abdominal pain** often out of proportion to physical exam findings and can lead to bowel infarction.
- However, the chest x-ray finding of **free air under the diaphragm** is not a primary feature of acute mesenteric ischemia unless bowel perforation has already occurred due to extensive necrosis, which is less common acutely than from a peptic ulcer.
*Gastroesophageal reflux disease*
- GERD primarily causes **heartburn**, regurgitation, and sometimes epigastric pain that worsens with eating or lying down.
- It does not typically cause **acute severe abdominal pain with guarding** or **free air under the diaphragm**.
*Acute pancreatitis*
- Acute pancreatitis presents with severe **epigastric pain radiating to the back**, often accompanied by nausea and vomiting, and can be associated with alcohol use.
- While severe, its clinical features would not include **free air under the diaphragm** on imaging unless it has led to a rare complication like bowel perforation due to severe inflammation or necrosis.
Question 108: A 63-year-old man is brought to the emergency department for evaluation of abdominal pain. The pain started four days ago and is now a diffuse crampy pain with an intensity of 6/10. The patient has nausea and has vomited twice today. His last bowel movement was three days ago. He has a history of hypertension and recurrent constipation. Five years ago, he underwent emergency laparotomy for a perforated duodenal ulcer. His father died of colorectal cancer at the age of 65 years. The patient has been smoking one pack of cigarettes daily for the past 40 years. Current medications include lisinopril and lactulose. His temperature is 37.6°C (99.7°F), pulse is 89/min, and blood pressure is 120/80 mm Hg. Abdominal examination shows distention and mild tenderness to palpation. There is no guarding or rebound tenderness. The bowel sounds are high-pitched. Digital rectal examination shows no abnormalities. An x-ray of the abdomen is shown. In addition to fluid resuscitation, which of the following is the most appropriate next step in the management of this patient?
A. Ciprofloxacin and metronidazole
B. Colonoscopy
C. Nasogastric tube placement and bowel rest (Correct Answer)
D. Surgical bowel decompression
E. PEG placement and enteral feeding
Explanation: ***Nasogastric tube placement and bowel rest***
- The patient presents with symptoms and signs consistent with a **small bowel obstruction (SBO)**, including diffuse crampy abdominal pain, nausea, vomiting, obstipation, abdominal distention, and high-pitched bowel sounds. The prior **laparotomy for a perforated duodenal ulcer** increases the risk for adhesions, which are the most common cause of SBO.
- Initial management for uncomplicated SBO involves **conservative measures** such as **nasogastric (NG) tube placement** for decompression, intravenous **fluid resuscitation**, and **bowel rest** to reduce distention and relieve symptoms.
*Ciprofloxacin and metronidazole*
- This antibiotic regimen is used for suspected **intra-abdominal infections**, such as diverticulitis or peritonitis, which are not the primary concern here given the lack of fever, severe tenderness, or rebound.
- While antibiotics might be considered if there were signs of **bowel ischemia or perforation**, the current presentation points to an obstruction without immediate signs of infection.
*Colonoscopy*
- **Colonoscopy** is primarily used for diagnosing and treating **lower gastrointestinal conditions**, like colorectal cancer or inflammatory bowel disease, or for evaluating unexplained lower GI bleeding.
- It is **contraindicated in acute SBO** due to the risk of perforation and would not alleviate the proximal bowel distention.
*Surgical bowel decompression*
- While **surgery is indicated for complicated SBO** (e.g., bowel ischemia, perforation, closed-loop obstruction, or strangulation), it is not the immediate first step for an uncomplicated SBO.
- **Conservative management** with NG tube decompression and bowel rest is typically attempted first, and if unsuccessful or if complications arise, then surgery is considered.
*PEG placement and enteral feeding*
- **Percutaneous endoscopic gastrostomy (PEG)** tube placement is used for **long-term enteral nutrition** in patients who cannot swallow or maintain adequate oral intake for an extended period.
- It is **not indicated for acute management of SBO**, as the goal is to *decompress* the bowel, not to provide enteral nutrition via the stomach in the presence of an obstruction.
Question 109: A 67-year-old man presents to the emergency department with abdominal pain that started 1 hour ago. The patient has a past medical history of diabetes and hypertension as well as a 40 pack-year smoking history. His blood pressure is 107/58 mmHg, pulse is 130/min, respirations are 23/min, and oxygen saturation is 98% on room air. An abdominal ultrasound demonstrates focal dilation of the aorta with peri-aortic fluid. Which of the following is the best next step in management?
A. Serial annual abdominal ultrasounds
B. Emergent surgical intervention (Correct Answer)
C. Administer labetalol
D. Counsel the patient in smoking cessation
E. Urgent surgery within the next day
Explanation: ***Emergent surgical intervention***
- The patient's presentation with acute **abdominal pain**, **hypotension**, and **tachycardia** combined with ultrasound findings of focal aortic dilation and peri-aortic fluid strongly suggests a **ruptured abdominal aortic aneurysm (AAA)**.
- A ruptured AAA is a life-threatening emergency requiring immediate surgical repair to prevent further hemorrhage and death.
*Serial annual abdominal ultrasounds*
- This approach is appropriate for asymptomatic patients with smaller, stable AAAs (typically <5.5 cm) to monitor for growth.
- In this case, the patient is symptomatic with signs of rupture, making surveillance an inappropriate and dangerous management strategy.
*Administer labetalol*
- Medications like labetalol are used to control blood pressure in conditions like aortic dissection or to slow the progression of AAAs, but they are contraindicated in hypotensive patients with a ruptured AAA.
- In this patient, labetalol would worsen the existing hypotension and could lead to cardiovascular collapse.
*Counsel the patient in smoking cessation*
- Smoking cessation is a crucial long-term intervention to reduce the risk of AAA expansion and rupture.
- While important, it does not address the immediate, life-threatening emergency of a ruptured AAA.
*Urgent surgery within the next day*
- Waiting until the next day for surgery in a patient with a suspected ruptured AAA is unacceptable.
- The patient's hemodynamic instability (hypotension, tachycardia) indicates active bleeding, and any delay significantly increases morbidity and mortality.
Question 110: A 61-year-old man comes to the physician because of several episodes of dark urine over the past 2 weeks. He does not have dysuria or flank pain. He works in a factory that produces dyes. Since an accident at work 5 years ago, he has had moderate hearing loss bilaterally. He takes no medications. He has smoked a pack of cigarettes daily for 29 years and drinks one alcoholic beverage daily. Vital signs are within normal limits. Physical examination shows no abnormalities. His urine is pink; urinalysis shows 80 RBC/hpf but no WBCs. Cystoscopy shows a 3-cm mass in the bladder mucosa. The mass is resected. Pathologic examination shows an urothelial carcinoma with penetration into the muscular layer. An x-ray of the chest and a CT scan of the abdomen and pelvis with contrast show a normal upper urinary tract and normal lymph nodes. Which of the following is the most appropriate next step in management?
A. Palliative polychemotherapy
B. Transurethral resection of tumor with intravesical BCG instillation
C. Radical cystectomy (Correct Answer)
D. Transurethral resection of tumor with intravesical chemotherapy
E. Radiation therapy
Explanation: ***Radical cystectomy***
- The patient has an **urothelial carcinoma** that has **penetrated the muscular layer**. This indicates an **invasive bladder cancer (T2 or greater)**, for which radical cystectomy is the standard of care to achieve cure.
- While imaging showed no distant metastasis, the deep invasion into the muscle requires aggressive surgical removal of the bladder, prostate (in men), and seminal vesicles, along with pelvic lymph node dissection.
*Palliative polychemotherapy*
- This option is typically reserved for patients with widespread **metastatic disease** or those who are not surgical candidates, which is not the case here.
- The patient's initial workup shows no evidence of distant metastasis, making a curative approach like surgery more appropriate.
*Transurethral resection of tumor with intravesical BCG instillation*
- This approach, often used for **high-grade non-muscle invasive bladder cancer**, is insufficient for muscle-invasive disease.
- **BCG instillation** aims to prevent recurrence and progression in superficial disease but cannot eradicate cancer that has invaded the muscularis propria.
*Transurethral resection of tumor with intravesical chemotherapy*
- Similar to BCG, **intravesical chemotherapy** is primarily effective for **non-muscle invasive bladder cancer** to prevent recurrence or treat carcinoma in situ.
- It does not provide adequate treatment for cancer that has invaded the detrusor muscle, as systemic or deeper treatments are required.
*Radiation therapy*
- While radiation therapy can be considered for bladder cancer, it is typically used in specific situations, such as for patients who are **not surgical candidates** or as part of a **bladder-sparing trimodality therapy** (TURBT, chemotherapy, and radiation) for highly selected patients.
- For muscle-invasive disease without clear contraindications for surgery, **radical cystectomy** offers better long-term survival rates.