A 23-year-old woman is brought to the emergency department by her boyfriend because of a 4-month history of feeling sad. Her boyfriend says that, during this period, she has slept and eaten very little and has been unable to focus at work. She says that she feels “empty inside” and has been hearing voices telling her that she is worthless. She first heard these voices 7 months ago when they started to make fun of her. She does not drink alcohol or use illicit drugs. Physical and neurological examinations show no abnormalities. On mental status examination, her speech is slow and monotonous; she abruptly stops talking in the middle of sentences and does not finish them. She occasionally directs her attention to the ceiling as if she were listening to someone. Which of the following is the most likely diagnosis?
Q72
A 12-year-old boy is brought to a psychiatrist by his mother upon referral from his pediatrician. The mother describes that for the past 2 years her son has experienced episodes of repetitive blinking and sudden jerking of the arms. Additionally, she notes that he often clears his throat and occasionally makes grunting noises. These symptoms have waxed and waned in frequency, but they have persisted for the past 2 years since they first developed. The patient is otherwise healthy without any coexisting medical issues. Which of the following agents would be effective at reducing the severity and frequency of this patient's current symptoms?
Q73
A 25-year-old man presents to his primary care physician with a chief complaint of "failing health." He states that he typically can converse with animals via telepathy, but is having trouble right now due to the weather. He has begun taking an assortment of Peruvian herbs to little avail. Otherwise he is not currently taking any medications. The patient lives alone and works in a health food store. He states that his symptoms have persisted for the past eight months. On physical exam, you note a healthy young man who is dressed in an all burlap ensemble. When you are obtaining the patient's medical history there are several times he is attempting to telepathically connect with the animals in the vicinity. Which of the following is the most likely diagnosis?
Q74
A 60-year-old man is brought to the emergency department by police officers because he was acting strangely in public. The patient was found talking nonsensically to characters on cereal boxes in the store. Past medical history is significant for multiple hospitalizations for alcohol-related injuries and seizures. The patient’s vital signs are within normal limits. Physical examination shows a disheveled male who is oriented to person, but not time or place. Neurologic examination shows nystagmus and severe gait ataxia. A T1/T2 MRI is performed and demonstrates evidence of damage to the mammillary bodies. The patient is given the appropriate treatment for recovering most of his cognitive functions. However, significant short-term memory deficits persist. The patient remembers events from his past such as the school and college he attended, his current job, and the names of family members quite well. Which of the following is the most likely diagnosis in this patient?
Q75
A 19-year-old man is brought to the emergency department by the resident assistant of his dormitory for strange behavior. He was found locked out of his room, where the patient admitted to attending a fraternity party before becoming paranoid that the resident assistant would report him to the police. The patient appears anxious. His pulse is 105/min, and blood pressure is 142/85 mm Hg. Examination shows dry mucous membranes and bilateral conjunctival injection. Further evaluation is most likely to show which of the following?
Q76
A 75-year-old woman presents to her primary care physician with her son because she is convinced that people are stealing from her. Her son claims she has been misplacing her medications and money throughout the house. She recently lost her husband to old age and has become reclusive and no longer wants people to visit. Physical examination is unremarkable and the patient is oriented to person, time, and place. A mini-mental status examination (MMSE) is performed and she has difficulty recalling words after 5 minutes and also has problems with serial subtraction. Which of the following is the most likely diagnosis in this patient?
Q77
A 77-year-old woman is brought to her primary care provider by her daughter with behavioral changes and an abnormally bad memory for the past few months. The patient’s daughter says she sometimes gets angry and aggressive while at other times she seems lost and stares at her surroundings. Her daughter also reports that she has seen her mother talking to empty chairs. The patient says she sleeps well during the night but still feels sleepy throughout the day. She has no problems getting dressed and maintaining her one bedroom apartment. Past medical history is significant for mild depression and mild osteoporosis. Current medications include escitalopram, alendronic acid, and a multivitamin. The patient is afebrile, and her vital signs are within normal limits. On physical examination, the patient is alert and oriented and sitting comfortably in her chair. A mild left-hand tremor is noted. Muscle strength is 5 out of 5 in the upper and lower extremities bilaterally, but muscle tone is slightly increased. She can perform repetitive alternating movements albeit slowly. She walks with a narrow gait and has mild difficulty turning. Which of the following is the most likely diagnosis in this patient?
Q78
A 42-year-old woman is in the hospital recovering from a cholecystectomy performed 3 days ago that was complicated by cholangitis. She is being treated with IV piperacillin-tazobactam. She calls the nurse to her room because she says that her heart is racing. She also demands that someone come in to clean the pile of garbage off of the floor because it is attracting flies. Her pulse is 112/min, respiratory rate is 20/min, temperature is 38.0°C (100.4°F), and blood pressure is 150/90 mm Hg. On physical examination, the patient appears sweaty, distressed, and unable to remain still. She is oriented to person, but not place or time. Palpation of the abdomen shows no tenderness, rebound, or guarding. Which of the following is the most likely diagnosis in this patient?
Psychotic Disorders US Medical PG Practice Questions and MCQs
Question 71: A 23-year-old woman is brought to the emergency department by her boyfriend because of a 4-month history of feeling sad. Her boyfriend says that, during this period, she has slept and eaten very little and has been unable to focus at work. She says that she feels “empty inside” and has been hearing voices telling her that she is worthless. She first heard these voices 7 months ago when they started to make fun of her. She does not drink alcohol or use illicit drugs. Physical and neurological examinations show no abnormalities. On mental status examination, her speech is slow and monotonous; she abruptly stops talking in the middle of sentences and does not finish them. She occasionally directs her attention to the ceiling as if she were listening to someone. Which of the following is the most likely diagnosis?
A. Schizophreniform disorder
B. Schizoaffective disorder (Correct Answer)
C. Schizotypal personality disorder
D. Mood disorder with psychotic features
E. Schizophrenia
Explanation: ***Schizoaffective disorder***
- The patient presents with a **major depressive episode** (sadness, anhedonia, sleep and appetite disturbance, poor concentration, feelings of worthlessness) concurrent with **psychotic symptoms** (auditory hallucinations) for 4 months.
- A key diagnostic criterion for schizoaffective disorder is the presence of **psychotic symptoms for at least 2 weeks in the absence of a major mood episode**, which is met by the prolonged duration of voices starting 7 months ago, while the depressive symptoms have been present for 4 months.
*Schizophreniform disorder*
- This disorder involves a constellation of **psychotic symptoms** lasting at least 1 month but **less than 6 months**.
- While she has psychotic symptoms, the prominent and prolonged mood symptoms (sadness, anhedonia, changes in sleep/appetite) suggest a mood component beyond what is typically seen in schizophreniform disorder.
*Schizotypal personality disorder*
- Characterized by pervasive patterns of social and interpersonal deficits marked by **acute discomfort** with, and **reduced capacity for, close relationships**, as well as **cognitive or perceptual distortions** and eccentric behaviors.
- This diagnosis does not account for the prominent mood symptoms (major depressive episode) and the clear psychotic symptoms (persistent auditory hallucinations independent of mood state) described in the patient.
*Mood disorder with psychotic features*
- In a mood disorder with psychotic features, the **psychotic symptoms occur exclusively during the mood episodes**.
- The patient reported hearing voices "7 months ago," while her depressive symptoms started "4 months ago," indicating that the **psychotic features preceded and occurred independently of the major depressive episode** for at least a 3-month period.
*Schizophrenia*
- Schizophrenia requires at least **6 months of continuous signs of disturbance**, including at least 1 month of **active-phase symptoms** (delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, negative symptoms).
- While the patient has psychotic symptoms for 7 months, the prominent and lengthy mood symptoms that occurred concurrently and independently of the psychosis point away from a primary diagnosis of schizophrenia.
Question 72: A 12-year-old boy is brought to a psychiatrist by his mother upon referral from his pediatrician. The mother describes that for the past 2 years her son has experienced episodes of repetitive blinking and sudden jerking of the arms. Additionally, she notes that he often clears his throat and occasionally makes grunting noises. These symptoms have waxed and waned in frequency, but they have persisted for the past 2 years since they first developed. The patient is otherwise healthy without any coexisting medical issues. Which of the following agents would be effective at reducing the severity and frequency of this patient's current symptoms?
A. Baclofen
B. Gabapentin
C. Sertraline
D. Fluphenazine (Correct Answer)
E. Valproic acid
Explanation: ***Fluphenazine***
- This patient presents with **motor and vocal tics** that have persisted for over a year, consistent with **Tourette's disorder**. **Fluphenazine**, a **first-generation antipsychotic**, is highly effective in blocking **dopamine D2 receptors** and reducing tic severity and frequency.
- **Tourette's disorder management** often involves antipsychotics like fluphenazine when tics are severe and impairing, as they directly address the presumed **dopaminergic hyperactivity** underlying the condition.
*Baclofen*
- **Baclofen** is a **GABA-B receptor agonist** primarily used as a **muscle relaxant** for spasticity, commonly seen in conditions like multiple sclerosis or spinal cord injuries.
- While tics involve muscle movements, they are not primarily spasticity and therefore would not be effectively treated with baclofen.
*Gabapentin*
- **Gabapentin** is an **anticonvulsant** and neuropathic pain medication that modulates **GABAergic neurotransmission**, but its mechanism is not directly targeting the **dopaminergic pathways** implicated in Tourette's.
- It is often used for **neuropathic pain**, **seizures**, and sometimes anxiety, none of which are the primary issue here.
*Sertraline*
- **Sertraline** is a **selective serotonin reuptake inhibitor (SSRI)** used to treat depression, anxiety disorders, and obsessive-compulsive disorder (OCD).
- While OCD can co-occur with Tourette's, sertraline would not directly treat the **tics** themselves, which are primarily related to dopamine dysregulation.
*Valproic acid*
- **Valproic acid** is a broad-spectrum **anticonvulsant** and **mood stabilizer** used for seizures, bipolar disorder, and migraine prevention.
- It works by increasing **GABA levels** and blocking **voltage-gated sodium channels**, but it is not a first-line or primary treatment for the reduction of tics in Tourette's disorder.
Question 73: A 25-year-old man presents to his primary care physician with a chief complaint of "failing health." He states that he typically can converse with animals via telepathy, but is having trouble right now due to the weather. He has begun taking an assortment of Peruvian herbs to little avail. Otherwise he is not currently taking any medications. The patient lives alone and works in a health food store. He states that his symptoms have persisted for the past eight months. On physical exam, you note a healthy young man who is dressed in an all burlap ensemble. When you are obtaining the patient's medical history there are several times he is attempting to telepathically connect with the animals in the vicinity. Which of the following is the most likely diagnosis?
A. Brief psychotic disorder
B. Schizoid personality disorder
C. Schizophrenia
D. Schizophreniform disorder
E. Schizotypal personality disorder (Correct Answer)
Explanation: ***Schizotypal personality disorder***
- This patient exhibits **eccentric behavior**, **magical thinking** (telepathy with animals), and **odd perceptions** that are characteristic of schizotypal personality disorder.
- The duration of symptoms (eight months) is consistent with a personality disorder, as these patterns are pervasive and long-standing.
*Brief psychotic disorder*
- Symptoms of brief psychotic disorder must last for **at least one day but less than one month**, with eventual full return to premorbid functioning.
- This patient's symptoms have persisted for eight months, making this diagnosis unlikely.
*Schizoid personality disorder*
- Characterized by **detachment from social relationships** and a restricted range of emotional expression, with no interest in social interactions.
- While this patient lives alone, his primary symptoms are **peculiar thoughts and behaviors**, not primarily a lack of social interest or flattened affect.
*Schizophrenia*
- Requires continuous signs of disturbance for **at least six months**, including at least one month of **active-phase symptoms** (delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior, negative symptoms).
- While this patient has some peculiar symptoms, they do not meet the full criteria for schizophrenia, lacking clear-cut delusions or hallucinations and having a more pervasive pattern of oddness.
*Schizophreniform disorder*
- Involves symptoms similar to schizophrenia but with a duration of **at least one month but less than six months**.
- This patient's symptoms have lasted eight months, exceeding the maximum duration for schizophreniform disorder.
Question 74: A 60-year-old man is brought to the emergency department by police officers because he was acting strangely in public. The patient was found talking nonsensically to characters on cereal boxes in the store. Past medical history is significant for multiple hospitalizations for alcohol-related injuries and seizures. The patient’s vital signs are within normal limits. Physical examination shows a disheveled male who is oriented to person, but not time or place. Neurologic examination shows nystagmus and severe gait ataxia. A T1/T2 MRI is performed and demonstrates evidence of damage to the mammillary bodies. The patient is given the appropriate treatment for recovering most of his cognitive functions. However, significant short-term memory deficits persist. The patient remembers events from his past such as the school and college he attended, his current job, and the names of family members quite well. Which of the following is the most likely diagnosis in this patient?
A. Schizophrenia
B. Korsakoff's syndrome (Correct Answer)
C. Wernicke encephalopathy
D. Delirium
E. Delirium tremens
Explanation: ***Korsakoff's syndrome***
- The patient's history of **chronic alcohol abuse**, along with **gait ataxia**, **nystagmus**, and most notably, significant **anterograde amnesia** (inability to form new long-term memories) despite preserved remote memory, points to Korsakoff's syndrome.
- **Damage to the mammillary bodies** on MRI is a classic finding in Korsakoff's syndrome, a direct result of **thiamine deficiency**.
- The patient demonstrates the characteristic pattern: **impaired new memory formation** while retaining memories from his past (school, college, job, family names).
*Schizophrenia*
- Schizophrenia typically presents with **hallucinations and delusions** (e.g., talking to cereal box characters), but it is not commonly associated with physical signs like **nystagmus** or **gait ataxia**, nor with MRI findings of mammillary body damage.
- While the initial presentation of talking to cereal box characters might suggest psychosis, the complete clinical picture, especially the neurological deficits and persistent memory impairment, points away from schizophrenia as the primary diagnosis.
*Wernicke encephalopathy*
- Wernicke encephalopathy shares symptoms like **nystagmus** and **ataxia** with this patient and is also due to **thiamine deficiency** in alcoholics.
- However, Wernicke encephalopathy typically presents with more acute and severe symptoms, including **global confusion** and **ophthalmoplegia**, and represents the acute phase. The dominant chronic **anterograde amnesia** described here is characteristic of Korsakoff's syndrome, which represents the chronic sequela.
*Delirium*
- Delirium is characterized by an **acute disturbance in attention and cognition**, often with a fluctuating course, and can be seen in alcohol withdrawal.
- While the patient shows some disorientation, the chronic nature of the symptoms, the specific neurological deficits (nystagmus, ataxia), and particularly the persistent, isolated **anterograde amnesia** are not typical features of delirium.
*Delirium tremens*
- Delirium tremens is a severe form of **alcohol withdrawal** characterized by **autonomic hyperactivity**, severe delirium, hallucinations, and seizures.
- While the patient has a history of alcohol-related seizures, his current vital signs are normal, and the persistent, chronic memory deficits and specific MRI findings are not hallmarks of acute delirium tremens but rather a chronic neurological complication.
Question 75: A 19-year-old man is brought to the emergency department by the resident assistant of his dormitory for strange behavior. He was found locked out of his room, where the patient admitted to attending a fraternity party before becoming paranoid that the resident assistant would report him to the police. The patient appears anxious. His pulse is 105/min, and blood pressure is 142/85 mm Hg. Examination shows dry mucous membranes and bilateral conjunctival injection. Further evaluation is most likely to show which of the following?
A. Impaired reaction time (Correct Answer)
B. Synesthesia
C. Pupillary constriction
D. Tactile hallucinations
E. Sense of closeness to others
Explanation: ***Impaired reaction time***
- The patient's presentation with **paranoia**, **anxiety**, **tachycardia**, **hypertension**, **dry mucous membranes**, and **conjunctival injection** is highly suggestive of **cannabis intoxication**.
- **Cannabis use** is known to **impair reaction time**, cognitive function, and motor coordination.
*Synesthesia*
- **Synesthesia** is a perceptual phenomenon where stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway (e.g., "seeing sounds" or "tasting words").
- While associated with some hallucinogens such as **LSD**, it is not a typical or expected finding with **cannabis intoxication**.
*Pupillary constriction*
- **Cannabis use** typically causes **mild to moderate mydriasis** (pupillary dilation) due to its sympathomimetic effects, not pupillary constriction.
- **Pupillary constriction** (miosis) is more commonly associated with **opioid intoxication**.
*Tactile hallucinations*
- While hallucinations can occur with **high doses of cannabis**, **tactile hallucinations** (e.g., feeling bugs crawling on skin) are more characteristic of **stimulant intoxication** (e.g., cocaine, amphetamines) or severe alcohol withdrawal.
- Auditory or visual hallucinations with cannabis are typically less organized and less common than with other hallucinogens.
*Sense of closeness to others*
- While some users report feelings of **euphoria** or **relaxation** with cannabis, a specific "sense of closeness to others" is not a universally reported or diagnostic symptom.
- The patient's **paranoid behavior** in this scenario contradicts a feeling of closeness.
Question 76: A 75-year-old woman presents to her primary care physician with her son because she is convinced that people are stealing from her. Her son claims she has been misplacing her medications and money throughout the house. She recently lost her husband to old age and has become reclusive and no longer wants people to visit. Physical examination is unremarkable and the patient is oriented to person, time, and place. A mini-mental status examination (MMSE) is performed and she has difficulty recalling words after 5 minutes and also has problems with serial subtraction. Which of the following is the most likely diagnosis in this patient?
A. Histrionic personality disorder
B. Schizophrenia
C. Delirium
D. Schizoid personality disorder
E. Dementia (Correct Answer)
Explanation: ***Dementia***
- The patient has **primary cognitive impairment** evidenced by MMSE deficits (poor delayed recall, impaired serial subtraction) and functional decline (misplacing items).
- Her **delusions of theft are secondary to dementia**, a common behavioral and psychological symptom of dementia (BPSD), particularly in Alzheimer's disease.
- The **insidious onset** in a 75-year-old with progressive memory decline points to a neurodegenerative process.
- Orientation remains intact in early-to-moderate dementia, which doesn't rule out the diagnosis.
- The stressor (husband's death) may have unmasked or accelerated symptom recognition but doesn't explain the cognitive deficits.
*Histrionic personality disorder*
- Characterized by **excessive emotionality** and **attention-seeking behavior**, which are not evident in this presentation.
- Personality disorders are lifelong patterns, not new-onset conditions in elderly patients with cognitive decline.
- Does not explain the objective cognitive deficits on MMSE.
*Schizophrenia*
- Schizophrenia typically has onset in **late adolescence to early adulthood**, not at age 75.
- While late-onset schizophrenia exists, the **prominent cognitive impairment** (memory, executive function) as the PRIMARY feature points toward dementia rather than a primary psychotic disorder.
- Schizophrenia would show more pervasive psychotic symptoms without the specific pattern of memory and executive dysfunction seen here.
*Delirium*
- Delirium has **acute onset** (hours to days) with **fluctuating consciousness** and altered attention.
- This patient is **oriented to person, time, and place** and has a gradual, progressive course (misplacing items over time).
- No mention of acute medical illness, medication changes, or rapid cognitive fluctuation.
*Schizoid personality disorder*
- A lifelong pattern of **social detachment** and restricted emotional expression, not a new condition in late life.
- Does not explain the cognitive impairment, memory deficits, or delusional beliefs.
- The patient's reclusiveness is reactive to recent loss and concerns about theft, not a longstanding personality trait.
Question 77: A 77-year-old woman is brought to her primary care provider by her daughter with behavioral changes and an abnormally bad memory for the past few months. The patient’s daughter says she sometimes gets angry and aggressive while at other times she seems lost and stares at her surroundings. Her daughter also reports that she has seen her mother talking to empty chairs. The patient says she sleeps well during the night but still feels sleepy throughout the day. She has no problems getting dressed and maintaining her one bedroom apartment. Past medical history is significant for mild depression and mild osteoporosis. Current medications include escitalopram, alendronic acid, and a multivitamin. The patient is afebrile, and her vital signs are within normal limits. On physical examination, the patient is alert and oriented and sitting comfortably in her chair. A mild left-hand tremor is noted. Muscle strength is 5 out of 5 in the upper and lower extremities bilaterally, but muscle tone is slightly increased. She can perform repetitive alternating movements albeit slowly. She walks with a narrow gait and has mild difficulty turning. Which of the following is the most likely diagnosis in this patient?
A. Lewy body dementia (Correct Answer)
B. Alzheimer's disease
C. Serotonin syndrome
D. Frontotemporal dementia
E. Delirium
Explanation: ***Lewy body dementia***
- This patient exhibits **fluctuating cognition** (being lost and staring, behavioral changes), **recurrent visual hallucinations** (talking to empty chairs), and spontaneous motor features of **parkinsonism** (mild left-hand tremor, increased muscle tone, slow alternating movements, narrow gait, difficulty turning), all core features of Lewy body dementia.
- The **insidious onset** and progressive decline over months, along with the symptom triad, fit the diagnostic criteria for Lewy body dementia.
*Alzheimer's disease*
- While Alzheimer's involves memory loss and cognitive decline, it is not typically associated with **prominent early visual hallucinations** or **parkinsonian features** at presentation.
- Alzheimer's disease often presents with **memory impairment as the most prominent early symptom**, often preceding other cognitive deficits by years.
*Serotonin syndrome*
- This is an acute drug reaction characterized by a triad of **mental status changes**, **autonomic hyperactivity**, and **neuromuscular abnormalities**, usually developing rapidly after medication changes affecting serotonin levels.
- The patient's symptoms have been present for months, the vital signs are stable, and her medications (escitalopram) have been stable, making an **acute syndrome** like serotonin syndrome unlikely.
*Frontotemporal dementia*
- This type of dementia primarily affects personality, behavior, and language, with **prominent disinhibition or apathy**.
- While behavioral changes are present, the patient's prominent **visual hallucinations** and **parkinsonian features** are not characteristic of frontotemporal dementia.
*Delirium*
- Delirium is characterized by an **acute onset** and fluctuating course of attention and awareness, often triggered by an underlying medical condition, medication, or infection.
- The patient's symptoms have progressed over **several months**, rather than hours or days, and she is afebrile with stable vital signs, making delirium less likely.
Question 78: A 42-year-old woman is in the hospital recovering from a cholecystectomy performed 3 days ago that was complicated by cholangitis. She is being treated with IV piperacillin-tazobactam. She calls the nurse to her room because she says that her heart is racing. She also demands that someone come in to clean the pile of garbage off of the floor because it is attracting flies. Her pulse is 112/min, respiratory rate is 20/min, temperature is 38.0°C (100.4°F), and blood pressure is 150/90 mm Hg. On physical examination, the patient appears sweaty, distressed, and unable to remain still. She is oriented to person, but not place or time. Palpation of the abdomen shows no tenderness, rebound, or guarding. Which of the following is the most likely diagnosis in this patient?
A. Delirium tremens (Correct Answer)
B. Alcoholic hallucinosis
C. Hepatic encephalopathy
D. Thyroid storm
E. Acute cholangitis
Explanation: ***Delirium tremens***
- The patient's symptoms, including **delirium**, **tachycardia**, **sweating**, **agitation**, and **visual hallucinations** (seeing garbage and flies), are highly indicative of **alcohol withdrawal delirium**, also known as delirium tremens, which typically peaks 48-96 hours after the last drink.
- Her recent surgery and hospitalization likely disrupted her usual alcohol intake, precipitating withdrawal.
*Alcoholic hallucinosis*
- This condition involves **prominent auditory or visual hallucinations** without significant disorientation or global cognitive impairment, whereas the patient presents with disorientation to place and time.
- It usually occurs within 12-48 hours after the last drink and typically does not include the significant autonomic instability (tachycardia, diaphoresis) seen in this patient.
*Hepatic encephalopathy*
- While the patient has a history of cholangitis, a condition that could potentially lead to liver dysfunction, there are no specific signs of **liver failure** such as **asterixis**, **jaundice**, or significantly elevated **ammonia levels** mentioned.
- Hepatic encephalopathy typically presents with impaired consciousness, confusion, and asterixis but lacks the intense psychomotor agitation, prominent hallucinations, and severe autonomic hyperactivity characteristic of delirium tremens.
*Thyroid storm*
- Thyroid storm would also present with tachycardia, fever, and agitation, but it would typically include other signs of **hyperthyroidism** such as **goiter**, **exophthalmos**, and more pronounced fever, which are not described.
- While agitation and tachycardia are present, the specific nature of her hallucinations and disorientation, combined with the lack of classic thyroid storm features, makes this less likely.
*Acute cholangitis*
- The patient is recovering from a cholecystectomy complicated by cholangitis and is on IV antibiotics, but her current symptoms primarily involve **neurological and psychomotor agitation** rather than worsening signs of infection or biliary obstruction.
- Although cholangitis can cause fever and tachycardia, it would not explain the prominent disorientation, agitation, and complex visual hallucinations found in this case without significant worsening of her infectious symptoms.