A 27-year-old man is brought into the emergency department by ambulance. The patient was at an appointment to receive welfare when he began acting abnormally. The patient was denied welfare. Shortly afterwards, he no longer responded to questions and stared blankly off into space, not responding to verbal stimuli. Other than odd lip-smacking behavior, he was motionless. Several minutes later, he became responsive but seemed confused. The patient has a past medical history of drug abuse and homelessness and is not currently taking any medications. His temperature is 98.9°F (37.2°C), blood pressure is 124/78 mmHg, pulse is 90/min, respirations are 14/min, and oxygen saturation is 99% on room air. Physical exam reveals cranial nerves II-XII as grossly intact with 5/5 strength in the upper and lower extremities and a stable gait. The patient seems confused when answering questions and has trouble remembering the episode. Which of the following is the most likely diagnosis?
Q32
Five days after undergoing surgical repair of a hip fracture, a 71-year-old man is agitated and confused. Last night, he had to be restrained multiple times after attempting to leave his room. His overnight nurse reported that at times he would be resting, but shortly afterward he would become agitated again for no clear reason. He has hypertension and COPD. He had smoked one pack of cigarettes daily for 50 years but quit 10 years ago. He drinks 1 glass of whiskey per day. His current medications include oxycodone, hydrochlorothiazide, albuterol, and ipratropium. He appears agitated. His temperature is 37°C (98.6°F), pulse is 72/min, and blood pressure is 141/84 mm Hg. Pulmonary examination shows a prolonged expiratory phase but no other abnormalities. Neurologic examination shows inattentiveness and no focal findings. He is oriented to person but not to place or time. During the examination, the patient attempts to leave the room after pulling out his intravenous line and becomes violent. He is unable to be verbally redirected and is placed on soft restraints. Laboratory studies show:
Hemoglobin 14.5 g/dL
Leukocyte count 8,000/mm3
Platelet count 245,000/mm3
Serum
Na+ 142 mEq/L
K+ 3.5 mEq/L
Cl- 101 mEq/L
HCO3- 24 mEq/L
Urea nitrogen 14 mg/dL
Creatinine 1.1 mg/dL
Urine dipstick shows no abnormalities. Which of the following is the most appropriate next step in management?
Q33
A 3-year-old boy is brought in by his mother because she is concerned that he has been “acting differently recently”. She says he no longer seems interested in playing with his friends from preschool, and she has noticed that he has stopped making eye contact with others. In addition, she says he flaps his hands when excited or angry and only seems to enjoy playing with objects that he can place in rows or rigid patterns. Despite these behaviors, he is meeting his language goals for his age (single word use). The patient has no significant past medical history. He is at the 90th percentile for height and weight for his age. He is afebrile and his vital signs are within normal limits. A physical examination is unremarkable. Which of the following is the most likely diagnosis in this patient?
Q34
A 29-year-old woman presents to the clinic regularly with her young daughter and complains that ever since her last delivery 5 years ago, she has been having intermittent light vaginal bleeding. She has seen several doctors so far and even some ‘specialist doctors.’ Her menstrual history also appears to be variable. Physical examination is within normal limits. Her urine analysis always seems to have > 10 RBCs/hpf. Which of the following is the most likely diagnosis?
Q35
A 23-year-old man presents to the emergency department with a chief complaint of being assaulted on the street. The patient claims that he has been followed by the government for quite some time and that he was assaulted by a government agent but was able to escape. He often hears voices telling him to hide. The patient has an unknown past medical history and admits to smoking marijuana frequently. On physical exam, the patient has no signs of trauma. When interviewing the patient, he is seen conversing with an external party that is not apparent to you. The patient states that he is afraid for his life and that agents are currently pursuing him. What is the best initial response to this patient’s statement?
Q36
A 35-year-old computer programmer presents to the psychiatrist at the request of his mother for his oddities. He explains that he wears an aluminum foil cap while he works because he does not want extraterrestrial life to steal his thoughts. He spends his free time building a radio transmitter to contact distant planets. He denies any delusions or hallucinations. He claims that nothing is wrong with his eccentricities and is happy the way his life is. Which of the following personality disorders does this male most likely have?
Q37
A 60-year-old man who was admitted for a fractured hip and is awaiting surgery presents with acute onset altered mental status. The patient is noted by the nurses to be shouting and screaming profanities and has already pulled out his IV and urine catheter. He says he believes he is being kept against his will and does not recall falling or fracturing his hip. The patient must be restrained by the staff to prevent him from getting out of bed. He is refusing a physical exam. Initial examination reveals an agitated elderly man with a trickle of blood flowing down his left arm. He is screaming and swinging his fists at the staff. The patient is oriented x 1. Which of the following is the next, best step in the management of this patient?
Q38
A 19-year-old man presents to a psychiatrist for the management of substance abuse. He reports that he started using the substance 2 years ago and that he smokes it after sprinkling it on his cigarette. He describes that after smoking the substance, he feels excited and as if he does not belong to himself. He also reports that when he is in his room, he sees vivid colors on the walls after using the substance; if he listens to his favorite music, he clearly sees colors and shapes in front of his eyes. There is no history of alcohol or nicotine abuse. The psychiatrist goes through his medical records and notes that he had presented with acute substance intoxication 1 month prior. At that point, his clinical features included delusions, amnesia, generalized erythema of his skin, tachycardia, hypertension, dilated pupils, dysarthria, and ataxia. Which of the following signs is also most likely to have been present on physical examination while the man was intoxicated with the substance?
Q39
A 24-year-old man presents to the emergency department after a suicide attempt. He is admitted to the hospital and diagnosed with schizoaffective disorder. A review of medical records reveals a history of illicit drug use, particularly cocaine and amphetamines. He is started on aripiprazole, paroxetine, and trazodone. At the time of discharge, he appeared more coherent and with a marked improvement in positive symptoms of hallucinations and delusions but still with a flat effect. During the patient’s first follow-up visit, his mother reports he has become increasingly agitated and restless despite compliance with his medications. She reports that her son’s hallucinations and delusions have stopped and he does not have suicidal ideations, but he cannot sit still and continuously taps his feet, wiggles his fingers, and paces in his room. When asked if anything is troubling him, he stands up and paces around the room. He says, “I cannot sit still. Something is happening to me.” A urine drug screen is negative. What is the next best step in the management of this patient?
Q40
A 24-year-old woman is brought to the hospital by her mother because she has "not been herself" for the past 3 months. The patient says she hears voices in her head. The mother said that when she is talking to her daughter she can’t seem to make out what she is saying; it is as if her thoughts are disorganized. When talking with the patient, you notice a lack of energy and an apathetic affect. Which of the following is the most likely diagnosis for this patient?
Psychotic Disorders US Medical PG Practice Questions and MCQs
Question 31: A 27-year-old man is brought into the emergency department by ambulance. The patient was at an appointment to receive welfare when he began acting abnormally. The patient was denied welfare. Shortly afterwards, he no longer responded to questions and stared blankly off into space, not responding to verbal stimuli. Other than odd lip-smacking behavior, he was motionless. Several minutes later, he became responsive but seemed confused. The patient has a past medical history of drug abuse and homelessness and is not currently taking any medications. His temperature is 98.9°F (37.2°C), blood pressure is 124/78 mmHg, pulse is 90/min, respirations are 14/min, and oxygen saturation is 99% on room air. Physical exam reveals cranial nerves II-XII as grossly intact with 5/5 strength in the upper and lower extremities and a stable gait. The patient seems confused when answering questions and has trouble remembering the episode. Which of the following is the most likely diagnosis?
A. Absence seizure
B. Malingering
C. Focal impaired awareness seizure (Correct Answer)
D. Transient ischemic attack
E. Generalized seizure
Explanation: ***Focal impaired awareness seizure***
- The patient's presentation with a period of **unresponsiveness**, **staring blankly**, repetitive **lip-smacking automatisms**, and subsequent **postictal confusion** and **amnesia of the event** are highly characteristic of a focal impaired awareness seizure (formerly called complex partial seizure).
- This seizure type originates from a **focal area of the brain** (often temporal lobe) and involves **impaired consciousness** during the episode.
- The context of significant stress (welfare denial) can sometimes precipitate seizures in susceptible individuals, although it is not a direct cause.
- **Automatisms** (repetitive purposeless movements like lip-smacking) are a hallmark feature.
*Absence seizure*
- Absence seizures are typically **brief (seconds)**, characterized by a sudden **cessation of activity and blank stares**, without automatisms like lip-smacking.
- Patients usually have **no postictal confusion** or memory loss of the event, which contradicts this patient's presentation.
- More common in **children** rather than adults.
*Malingering*
- Malingering involves the **intentional feigning of symptoms** for secondary gain, but the presence of automatisms like lip-smacking and the postictal state are objective neurological signs not easily faked.
- The lack of responsiveness to verbal stimuli and subsequent confusion are clinical features inconsistent with volitional control.
*Transient ischemic attack*
- TIAs present with **focal neurological deficits** (e.g., weakness, speech disturbance, visual loss) that resolve completely within 24 hours, often without confusion.
- The symptoms described (staring, lip-smacking, generalized unresponsiveness, and confusion) are not typical of a TIA.
- More common in **older patients** with vascular risk factors.
*Generalized seizure*
- A generalized seizure, such as a tonic-clonic seizure, would involve **loss of consciousness** with **tonic and clonic movements** of the extremities, which are not described here.
- While postictal confusion is common, the focal automatisms and lack of widespread motor activity point away from a primary generalized seizure.
- Generalized seizures involve **both hemispheres** from onset, unlike this focal presentation.
Question 32: Five days after undergoing surgical repair of a hip fracture, a 71-year-old man is agitated and confused. Last night, he had to be restrained multiple times after attempting to leave his room. His overnight nurse reported that at times he would be resting, but shortly afterward he would become agitated again for no clear reason. He has hypertension and COPD. He had smoked one pack of cigarettes daily for 50 years but quit 10 years ago. He drinks 1 glass of whiskey per day. His current medications include oxycodone, hydrochlorothiazide, albuterol, and ipratropium. He appears agitated. His temperature is 37°C (98.6°F), pulse is 72/min, and blood pressure is 141/84 mm Hg. Pulmonary examination shows a prolonged expiratory phase but no other abnormalities. Neurologic examination shows inattentiveness and no focal findings. He is oriented to person but not to place or time. During the examination, the patient attempts to leave the room after pulling out his intravenous line and becomes violent. He is unable to be verbally redirected and is placed on soft restraints. Laboratory studies show:
Hemoglobin 14.5 g/dL
Leukocyte count 8,000/mm3
Platelet count 245,000/mm3
Serum
Na+ 142 mEq/L
K+ 3.5 mEq/L
Cl- 101 mEq/L
HCO3- 24 mEq/L
Urea nitrogen 14 mg/dL
Creatinine 1.1 mg/dL
Urine dipstick shows no abnormalities. Which of the following is the most appropriate next step in management?
A. Obtain CT scan of the head
B. Obtain urine culture
C. Administer lorazepam
D. Administer haloperidol (Correct Answer)
E. Obtain x-ray of the chest
Explanation: ***Administer haloperidol***
- The patient is exhibiting acute **delirium**, characterized by **agitation**, **confusion**, inattentiveness, and fluctuating mental status in a post-surgical setting.
- Given his **violent behavior**, inability to be verbally redirected, and **immediate danger to self/others** (pulling IV line, requiring restraints), pharmacological intervention is necessary for acute safety management.
- **Haloperidol** (a typical antipsychotic) has historically been used for severe agitation in delirium when the patient poses imminent danger, though current guidelines emphasize it should be used at the **lowest effective dose for the shortest duration** while underlying causes are addressed.
- Note: Antipsychotics do not treat the underlying delirium but manage dangerous agitation; concurrent evaluation for reversible causes (pain, infection, medications, alcohol withdrawal) remains essential.
*Obtain CT scan of the head*
- While a CT scan may be indicated in delirium workup to rule out **structural lesions** or **intracranial hemorrhage**, there are no focal neurological deficits, head trauma, or signs of increased intracranial pressure here.
- His delirium is likely multifactorial (postoperative state, opioid use, possible pain, stress), and CT would not address the immediate safety concern.
- Neuroimaging can be pursued after acute agitation is controlled.
*Obtain urine culture*
- **Urinary tract infections (UTIs)** are common delirium triggers in elderly patients, but the **urine dipstick is unremarkable** (no leukocyte esterase, nitrites, or WBCs), making UTI less likely.
- While a culture could be ordered as part of comprehensive workup, it does not address the immediate violent behavior.
*Obtain x-ray of the chest*
- A chest x-ray would be appropriate if there were signs of **pneumonia** (fever, cough, hypoxia, new lung sounds), but examination shows only a **prolonged expiratory phase** consistent with his known COPD.
- Pneumonia can cause delirium, but without acute respiratory symptoms, this is not the immediate priority over managing dangerous agitation.
*Administer lorazepam*
- **Benzodiazepines** like lorazepam are **contraindicated** in delirium unless the cause is alcohol or benzodiazepine withdrawal, as they can **worsen confusion**, cause paradoxical agitation, and increase fall risk in elderly patients.
- While the patient drinks 1 glass of whiskey daily, this level of consumption makes severe alcohol withdrawal less likely (though should still be assessed), and benzodiazepines carry significant risks of respiratory depression given his COPD.
- Antipsychotics are preferred for non-withdrawal delirium when pharmacological management is necessary.
Question 33: A 3-year-old boy is brought in by his mother because she is concerned that he has been “acting differently recently”. She says he no longer seems interested in playing with his friends from preschool, and she has noticed that he has stopped making eye contact with others. In addition, she says he flaps his hands when excited or angry and only seems to enjoy playing with objects that he can place in rows or rigid patterns. Despite these behaviors, he is meeting his language goals for his age (single word use). The patient has no significant past medical history. He is at the 90th percentile for height and weight for his age. He is afebrile and his vital signs are within normal limits. A physical examination is unremarkable. Which of the following is the most likely diagnosis in this patient?
A. Pervasive developmental disorder, not otherwise specified
B. Autism spectrum disorder (Correct Answer)
C. Rett’s disorder
D. Childhood disintegrative disorder
E. Asperger’s disorder
Explanation: ***Autism spectrum disorder***
- This patient exhibits **persistent deficits in social communication and social interaction** (e.g., lack of interest in friends, poor eye contact) and **restricted, repetitive patterns of behavior, interests, or activities** (e.g., hand flapping, lining up objects). These are the core diagnostic criteria for **autism spectrum disorder (ASD)**.
- The symptoms are presenting in **early childhood** (age 3) and are causing **clinically significant impairment** in social, occupational, or other important areas of current functioning, consistent with an ASD diagnosis.
*Pervasive developmental disorder, not otherwise specified*
- This diagnosis was previously used when a child met some, but not all, criteria for autistic disorder or when there was atypical presentation. However, under **DSM-5**, these conditions are now unified under the single diagnosis of **Autism Spectrum Disorder**.
- Its usage has been largely superseded by the broader diagnosis of **Autism Spectrum Disorder** in the DSM-5.
*Rett’s disorder*
- **Rett's disorder** primarily affects **females** and is characterized by a period of normal development followed by a loss of acquired hand skills, severe intellectual disability, and characteristic hand-wringing movements. This patient is a male and does not exhibit these specific features.
- Patients typically experience **regression** in language and motor skills after normal early development, which is not described in this case, and they develop **microcephaly**.
*Childhood disintegrative disorder*
- This diagnosis involves a **marked regression** in multiple areas of functioning (social, communication, motor) after at least **2 years of normal development**.
- The patient's mother notes recent changes, but there is no indication of previous normal development followed by significant loss of skills across multiple domains after age 2, which differentiates it from the insidious onset of ASD symptoms.
*Asperger’s disorder*
- **Asperger’s disorder** was characterized by **significant difficulties in social interaction** and **restricted, repetitive patterns of behavior**, but with **no clinically significant delay in language or cognitive development**.
- In **DSM-5**, Asperger's disorder is no longer a distinct diagnosis and is now subsumed under the umbrella of **Autism Spectrum Disorder**, which better reflects the spectrum of symptom severity.
Question 34: A 29-year-old woman presents to the clinic regularly with her young daughter and complains that ever since her last delivery 5 years ago, she has been having intermittent light vaginal bleeding. She has seen several doctors so far and even some ‘specialist doctors.’ Her menstrual history also appears to be variable. Physical examination is within normal limits. Her urine analysis always seems to have > 10 RBCs/hpf. Which of the following is the most likely diagnosis?
A. Somatic symptom disorder
B. Malingering
C. Illness anxiety disorder
D. Factitious disorder imposed on another
E. Factitious disorder (Correct Answer)
Explanation: ***Factitious disorder***
- This is characterized by the **intentional falsification of physical or psychological symptoms** with the primary motivation being to assume the sick role, without obvious external rewards. The patient in the vignette consistently presents with ambiguous symptoms (intermittent light vaginal bleeding, variable menstrual history, unexplained hematuria) that are not substantiated by objective findings, and seeks multiple consultations (doctor shopping).
- The patient's presentation with her daughter, the history of multiple doctor visits, and the lack of clear medical explanation despite persistent symptoms are all consistent with a desire to maintain the **"sick role"**, which is the defining feature of factitious disorder.
- Key features include: normal physical exam, persistent symptom reporting, healthcare utilization pattern, and absence of external incentives.
*Somatic symptom disorder*
- In **somatic symptom disorder**, patients experience genuine distress and anxiety about their symptoms and truly believe they are ill, rather than consciously fabricating or inducing symptoms.
- While these patients may also seek multiple medical opinions, they are not intentionally producing symptoms—they genuinely perceive their symptoms as real medical problems.
*Malingering*
- **Malingering** involves the intentional production of false or grossly exaggerated physical or psychological symptoms, but the motivation is explicitly for **external incentives** (e.g., avoiding work or military duty, obtaining financial compensation, evading criminal prosecution, or acquiring drugs).
- The vignette does not suggest any tangible external benefits that the patient is trying to obtain, making malingering less likely.
- Malingering is not considered a psychiatric disorder but rather a V-code/Z-code condition.
*Factitious disorder imposed on another*
- **Factitious disorder imposed on another** (formerly Munchausen syndrome by proxy) involves a caregiver (usually a parent) fabricating or inducing illness in another person (typically a child) to indirectly assume the sick role or gain attention for themselves.
- In this case, the patient is fabricating her own illness, not the illness of her daughter, so this diagnosis is incorrect.
*Illness anxiety disorder*
- In **illness anxiety disorder** (formerly hypochondriasis), patients have excessive worry about having or acquiring a serious illness, with minimal or no somatic symptoms present.
- These patients are not intentionally producing symptoms; rather, they misinterpret normal bodily sensations as signs of serious disease.
- The presence of fabricated physical findings (hematuria) and the pattern of doctor shopping without genuine anxiety about disease make this diagnosis less likely.
Question 35: A 23-year-old man presents to the emergency department with a chief complaint of being assaulted on the street. The patient claims that he has been followed by the government for quite some time and that he was assaulted by a government agent but was able to escape. He often hears voices telling him to hide. The patient has an unknown past medical history and admits to smoking marijuana frequently. On physical exam, the patient has no signs of trauma. When interviewing the patient, he is seen conversing with an external party that is not apparent to you. The patient states that he is afraid for his life and that agents are currently pursuing him. What is the best initial response to this patient’s statement?
A. I think you are safe from the agents here.
B. You have a mental disorder but don’t worry we will help you.
C. I don’t think any agents are pursuing you.
D. What medications are you currently taking?
E. It sounds like you have been going through some tough experiences lately. (Correct Answer)
Explanation: ***It sounds like you have been going through some tough experiences lately.***
- This response **acknowledges the patient's distress** and experience without validating or refuting their delusional beliefs.
- It helps establish **rapport** and encourages the patient to share more about their symptoms, which is crucial for assessment in a psychiatric emergency.
*I think you are safe from the agents here.*
- While intended to reassure, directly addressing the delusion can be perceived as dismissive and may **escalate the patient's paranoia** or agitation.
- It does not validate their *feelings* of fear, which are real to them, even if the source is delusional.
*You have a mental disorder but don’t worry we will help you.*
- This statement is **confrontational** and judgmental, labeling the patient immediately with a diagnosis.
- This approach can cause the patient to become defensive, shut down, or feel stigmatized, making further assessment and trust-building very difficult in the **initial interaction**.
*I don’t think any agents are pursuing you.*
- Directly **challenging a patient's delusion** is generally unhelpful in acute settings and can lead to increased agitation.
- It invalidates their subjective reality and can make them feel misunderstood or distrustful of the healthcare provider.
*What medications are you currently taking?*
- While important information, asking about medications is too premature as an *initial response* to a patient expressing severe paranoia and fear.
- This question comes across as dismissive of their current emotional state and **prioritizes medical history over emotional support** and rapport-building.
Question 36: A 35-year-old computer programmer presents to the psychiatrist at the request of his mother for his oddities. He explains that he wears an aluminum foil cap while he works because he does not want extraterrestrial life to steal his thoughts. He spends his free time building a radio transmitter to contact distant planets. He denies any delusions or hallucinations. He claims that nothing is wrong with his eccentricities and is happy the way his life is. Which of the following personality disorders does this male most likely have?
A. Schizotypal (Correct Answer)
B. Schizoid
C. Narcissistic
D. Borderline
E. Paranoid
Explanation: ***Schizotypal***
- This patient exhibits **eccentric behavior**, **odd beliefs** (aliens stealing thoughts), and **magical thinking** (radio transmitter for distant planets) without reaching the level of frank delusions or hallucinations.
- The patient's lack of concern about his "eccentricities" and satisfaction with his life are consistent with the **ego-syntonic nature** often seen in personality disorders.
*Schizoid*
- Characterized by a **detachment from social relationships** and a restricted range of emotional expression, often preferring solitary activities.
- While they may display some oddities, their primary feature is a **lack of interest in social interaction**, which is not the prominent feature described here.
*Narcissistic*
- Individuals with narcissistic personality disorder display a **pervasive pattern of grandiosity**, a need for admiration, and a lack of empathy.
- Their behaviors are typically driven by a need for **external validation** and a sense of superiority, which are absent in this case.
*Borderline*
- Marked by **instability in interpersonal relationships**, self-image, affects, and impulsivity; traits like fear of abandonment, unstable identity, and self-harm are common.
- The patient's presentation does not align with the **emotional dysregulation and interpersonal chaos** characteristic of borderline personality disorder.
*Paranoid*
- Characterized by a **pervasive distrust and suspiciousness of others**, interpreting their motives as malevolent.
- While the patient has unusual beliefs, his primary concern is about alien intervention, not **suspicion of human intentions** or behaviors.
Question 37: A 60-year-old man who was admitted for a fractured hip and is awaiting surgery presents with acute onset altered mental status. The patient is noted by the nurses to be shouting and screaming profanities and has already pulled out his IV and urine catheter. He says he believes he is being kept against his will and does not recall falling or fracturing his hip. The patient must be restrained by the staff to prevent him from getting out of bed. He is refusing a physical exam. Initial examination reveals an agitated elderly man with a trickle of blood flowing down his left arm. He is screaming and swinging his fists at the staff. The patient is oriented x 1. Which of the following is the next, best step in the management of this patient?
A. Order 24-hour restraints
B. Change his medication
C. Order CMP and CBC (Correct Answer)
D. Repair the fractured hip
E. Administer an Antipsychotic
Explanation: ***Order CMP and CBC***
- The patient is exhibiting **acute delirium**, characterized by altered mental status, disorientation, and agitation, especially common in elderly patients post-surgery or with underlying medical issues.
- Initial management involves identifying and addressing potential underlying medical causes such as **electrolyte imbalances**, **infection**, or **anemia** (evaluated by CMP and CBC).
*Order 24-hour restraints*
- While restraints might be necessary for patient safety in the short term, ordering 24-hour restraints without investigating the cause is not the **next best step**.
- Restraints should be used as a last resort, minimized in duration, and not as a primary management strategy for **delirium**.
*Change his medication*
- Changing medication without a clear understanding of the underlying cause of delirium could exacerbate the situation or introduce new complications.
- A thorough investigation to **identify the etiology** of his altered mental status is crucial before adjusting pharmacotherapy.
*Repair the fractured hip*
- The patient's acute delirium makes him an unstable candidate for surgery due to the increased risk of complications and difficulty with consent.
- Addressing the **acute medical instability** (delirium) takes precedence over elective or semi-elective surgical procedures.
*Administer an Antipsychotic*
- **Antipsychotics** can be used to manage severe agitation in delirium, but they are a symptomatic treatment and not the initial **diagnostic step**.
- Without identifying the underlying cause, administering medication could mask symptoms or have adverse effects, especially in an **elderly patient**.
Question 38: A 19-year-old man presents to a psychiatrist for the management of substance abuse. He reports that he started using the substance 2 years ago and that he smokes it after sprinkling it on his cigarette. He describes that after smoking the substance, he feels excited and as if he does not belong to himself. He also reports that when he is in his room, he sees vivid colors on the walls after using the substance; if he listens to his favorite music, he clearly sees colors and shapes in front of his eyes. There is no history of alcohol or nicotine abuse. The psychiatrist goes through his medical records and notes that he had presented with acute substance intoxication 1 month prior. At that point, his clinical features included delusions, amnesia, generalized erythema of his skin, tachycardia, hypertension, dilated pupils, dysarthria, and ataxia. Which of the following signs is also most likely to have been present on physical examination while the man was intoxicated with the substance?
A. Increased sensitivity to pain
B. Excessive perspiration
C. Hyporeflexia
D. Generalized hypotonia
E. Nystagmus (Correct Answer)
Explanation: ***Nystagmus***
- The patient's symptoms of **dissociation** ("feels as if he does not belong to himself"), **visual hallucinations** (seeing vivid colors and shapes), delusions, amnesia, tachycardia, hypertension, dilated pupils, dysarthria, and ataxia are highly characteristic of **phencyclidine (PCP) intoxication**.
- **Nystagmus**, particularly **horizontal and vertical nystagmus**, is a classic and frequently observed sign in PCP intoxication due to its effects on the **cerebellum** and vestibular system.
*Increased sensitivity to pain*
- PCP is known for its **analgesic** and **anesthetic** properties, leading to **decreased sensitivity to pain**, not increased.
- This effect contributes to the potential for self-injurious behavior during intoxication.
*Excessive perspiration*
- While other stimulants can cause diaphoresis, PCP intoxication more typically presents with **dry skin** or normal perspiration despite **hyperthermia** as it interferes with cholinergic thermoregulation.
- The described **generalized erythema** suggests **vasodilation**, but **dry skin** is more often associated with the anticholinergic effects that can accompany PCP.
*Hyporeflexia*
- PCP intoxication commonly causes **hyperreflexia** and **spasticity**, not hyporeflexia, due to its excitatory effects on the **central nervous system**.
- **Muscle rigidity** and **seizures** are also possible, further indicating CNS excitation.
*Generalized hypotonia*
- PCP typically leads to **increased muscle tone** and **rigidity**, not generalized hypotonia.
- The patient's presentation with **ataxia** and **dysarthria** suggests cerebellar involvement, but this usually manifests with motor incoordination rather than widespread flaccidity.
Question 39: A 24-year-old man presents to the emergency department after a suicide attempt. He is admitted to the hospital and diagnosed with schizoaffective disorder. A review of medical records reveals a history of illicit drug use, particularly cocaine and amphetamines. He is started on aripiprazole, paroxetine, and trazodone. At the time of discharge, he appeared more coherent and with a marked improvement in positive symptoms of hallucinations and delusions but still with a flat effect. During the patient’s first follow-up visit, his mother reports he has become increasingly agitated and restless despite compliance with his medications. She reports that her son’s hallucinations and delusions have stopped and he does not have suicidal ideations, but he cannot sit still and continuously taps his feet, wiggles his fingers, and paces in his room. When asked if anything is troubling him, he stands up and paces around the room. He says, “I cannot sit still. Something is happening to me.” A urine drug screen is negative. What is the next best step in the management of this patient?
A. Add propranolol (Correct Answer)
B. Increase the aripiprazole dose
C. Stop aripiprazole and switch to clozapine
D. Add lithium
E. Stop paroxetine
Explanation: ***Add propranolol***
- The patient's symptoms of **agitation**, **restlessness**, inability to sit still, **foot tapping**, and **finger wiggling** are highly suggestive of **akathisia**, a common extrapyramidal side effect of antipsychotic medications, particularly **aripiprazole**.
- **Beta-blockers**, such as **propranolol**, are the **first-line treatment** for akathisia due to their ability to provide symptomatic relief by reducing the adrenergic hyperactivity associated with this condition.
*Increase the aripiprazole dose*
- Increasing the dose of **aripiprazole** would likely **worsen** the akathisia, as it is a dose-dependent side effect of **antipsychotic medications**.
- The patient's positive symptoms are already controlled, so increasing the dose is not indicated and could cause more harm.
*Stop aripiprazole and switch to clozapine*
- While switching antipsychotics is an option for persistent side effects, abruptly stopping an effective medication like **aripiprazole** could lead to a **relapse of psychotic symptoms**.
- **Clozapine** is typically reserved for **treatment-resistant schizophrenia** and carries risks of severe side effects like **agranulocytosis**, making it an inappropriate first step for akathisia.
*Add lithium*
- **Lithium** is primarily used as a **mood stabilizer** for bipolar disorder and in augmenting antidepressants; it is not indicated for treating **akathisia**.
- While some cases of akathisia might be mistaken for mood episodes, the classic motor restlessness points to an **extrapyramidal side effect**.
*Stop paroxetine*
- **Paroxetine**, an **SSRI**, is less likely to cause severe akathisia compared to antipsychotics, and discontinuing it would not address the most probable cause of the patient's symptoms, which is the **aripiprazole**.
- Stopping the antidepressant could also exacerbate the patient's **mood symptoms**, given his history of **schizoaffective disorder** and prior suicide attempt.
Question 40: A 24-year-old woman is brought to the hospital by her mother because she has "not been herself" for the past 3 months. The patient says she hears voices in her head. The mother said that when she is talking to her daughter she can’t seem to make out what she is saying; it is as if her thoughts are disorganized. When talking with the patient, you notice a lack of energy and an apathetic affect. Which of the following is the most likely diagnosis for this patient?
A. Major depressive disorder
B. Schizophrenia
C. Brief psychotic disorder
D. Schizotypal disorder
E. Schizophreniform disorder (Correct Answer)
Explanation: ***Schizophreniform disorder***
- The patient exhibits core **psychotic symptoms** (hearing voices, disorganized thoughts) for a duration of **3 months**, which is characteristic of schizophreniform disorder (symptoms lasting **1 to 6 months**).
- Her **lack of energy** and **apathetic affect** align with the negative symptoms commonly seen in psychotic disorders.
*Major depressive disorder*
- While **lack of energy** and **apathetic affect** can be present, the prominent **hallucinations** (hearing voices) and **disorganized thoughts** are not primary features of major depressive disorder.
- A diagnosis of depression alone would not fully account for her psychotic symptoms.
*Schizophrenia*
- Schizophrenia requires symptoms to be present for **at least 6 months**, including at least one month of **active phase symptoms**. This patient's symptoms have only been present for 3 months.
- While the symptoms are consistent with schizophrenia, the **duration criterion** has not yet been met.
*Brief psychotic disorder*
- Brief psychotic disorder is characterized by psychotic symptoms lasting **less than 1 month**. This patient's symptoms have been ongoing for 3 months.
- The chronicity of symptoms makes this diagnosis unlikely.
*Schizotypal disorder*
- Schizotypal disorder is a **personality disorder** characterized by peculiar thoughts and behaviors, but typically **without overt psychotic episodes** or pronounced disorganized speech/hallucinations as described.
- While there may be odd beliefs or ideas of reference, the clear **auditory hallucinations** and **thought disorder** in this case point to a more severe psychotic condition.