A 20-year-old woman is brought to the physician by her mother because she has been worried about her daughter's strange behavior for the past 2 years. She does not have any friends and spends most of her time alone in her room. She usually wears a long, black, hooded cloak. She is anxious at college because she is uncomfortable around other people, and her academic performance is poor. She collects rare crystals and says that they support her “sixth sense.” Mental status examination shows slow, hesitant speech, and she avoids eye contact. Which of the following is the most likely diagnosis?
Q22
A 20-year-old male is involuntarily admitted to the county psychiatric unit for psychotic behavior over the past three months. The patient's mother explained to the psychiatrist that her son had withdrawn from family and friends, appeared to have no emotions, and had delusions that he was working for the CIA. When he spoke, his sentences did not always seem to have any connection with each other. The mother finally decided to admit her son after he began stating that he "revealed too much information to her and was going to be eliminated by the CIA." Which of the following diagnoses best fits this patient's presentation?
Q23
A 14-year-old boy is brought to the office by his step-parents because he was recently caught beating a stray cat in an alley near his home. He has a police record which includes vandalism, shoplifting, and running away on two occasions. He has also received several detentions and threats of expulsion from school due to bullying and being too aggressive with the younger students. Past medical history is significant for a history of ADHD previously treated with methylphenidate, but now he does not take anything. His biological family placed him and his sister into the foster care system. His step-parents try to provide support and nurturing home life but the patient is very resistant and often acts out. What is the most likely diagnosis for this patient?
Q24
At a counseling session, a 15-year-old boy recounts his childhood. He explained that his father was an angry, violent man who physically abused him and his younger brother every time he was drunk - which was almost every night. The boy said that the only way he could escape the situation was to believe that he himself was a superhero that would fight crime. Which of the following best describes the ego defense of this male?
Q25
A 27-year-old man is brought to the emergency department after he was found locked in a bathroom at a local gas station. The patient states that he was being followed. The patient is unable to reveal additional medical history due to his condition. The patient’s sister is contacted and states that he has trouble taking care of himself and has observed him maintaining a dialogue with what appears to be no one on several occasions. The patient’s temperature is 99.5°F (37.5°C), pulse is 90/min, blood pressure is 120/70 mmHg, respirations are 14/min, oxygen saturation is 98% on room air, and BMI is 22 kg/m^2. The patient is medicated and transferred to the inpatient psychiatric unit. The patient is kept there for three weeks and maintained on his medication regimen. Towards the end of his hospitalization, the patient is grooming himself properly, denies hearing voices, and no longer believes he is being followed. The patient’s temperature is 99.5°F (37.5°C), pulse is 80/min, blood pressure is 130/75 mmHg, respirations are 15/min, oxygen saturation is 98% on room air, and BMI is 24 kg/m^2. Which of the following medications was this patient most likely started on?
Q26
A 31-year-old woman is brought to the emergency department by EMS, activated by a bystander who found her wandering in the street. She provides short, vague answers to interview questions and frequently stops mid-sentence and stares at an empty corner of the room, appearing distracted. Her affect is odd but euthymic. Past medical history is notable for obesity and pre-diabetes. Collateral information from her brother reveals that she left home 3 days ago because she thought her family was poisoning her and has since been listed as a missing person. He also describes a progressive 2-year decline in her social interactions and self-care. The patient has no history of substance use and has never been prescribed psychiatric medications before but is amenable to starting a medication now. Which of the following would be the most appropriate as a first line medication for her?
Q27
An 8-year-old boy is brought in by his mother who is concerned about her child’s behavior. She says his teachers have complained about him bullying other students at school, starting fights, and stealing other children’s lunch money. She also says that a neighbor down the street called her 6 months ago and reported that the patient had entered her yard and started viciously kicking her dog. He has no significant past medical history. He is in the 90th percentile for height and weight and has been meeting all developmental milestones. The patient is afebrile and his vital signs are within normal limits. Which of the following adult personality disorders does this patient’s diagnosis most likely predict?
Q28
A 57-year-old man is brought to the physician for worsening mental status over the past 2 months. His wife reports he was initially experiencing lapses in memory and over the past 3 weeks he has begun having difficulties performing activities of daily living. Yesterday, he became lost heading to the post office down the street. He has hypertension treated with lisinopril and hydrochlorothiazide. Vital signs are within normal limits. He is alert but verbally uncommunicative. Muscle strength is normal. Reflexes are 2+ in bilateral upper and lower extremities. He has diffuse involuntary muscle jerking that can be provoked by loud noises. Mental status examination shows a blunt affect. A complete blood count and serum concentrations of glucose, creatinine, and electrolytes are within the reference range. Which of the following is the most likely diagnosis?
Q29
A 10-year-old boy is brought to the physician by his parents because they are concerned about his “strange behavior”. The parents state that he has always been a lonely kid without many friends, but recently he has been having behavioral problems that seem to be unprovoked and are occurring more frequently. The child throws tantrums for no reason and does not respond to punishment or reward. He also has a “strange obsession” with collecting rocks that he finds on his way to and from school to the point where his room is filled with rocks. He plays alone in his room, lining the rocks up, organizing them by size, shape, or color, and he will randomly bark or make high-pitched noises without provocation. His teachers say he daydreams a lot and is very good at art, being able to recreate his favorite cartoon characters in great detail. On physical assessment, the patient does not make eye contact with the physician but talks incessantly about his rock collection. The child’s grammar and vocabulary seem normal but his speech is slightly labored, and he can’t seem to tell that the physician is not really interested in hearing about his rock collection. Which of the following is the most likely diagnosis?
Q30
A 21-year-old man presents to an outpatient psychiatrist with chief complaints of fatigue and “hearing voices.” He describes multiple voices which sometimes call his name or say nonsensical things to him before he falls asleep at night. He occasionally awakes to see “strange people” in his room, which frighten him but then disappear. The patient is particularly worried by this because his uncle developed schizophrenia when he was in his 20s. The patient also thinks he had a seizure a few days ago, saying he suddenly fell to the ground without warning, though he remembers the episode and denied any abnormal movements during it. He is in his 3rd year of college and used to be a top student, but has been getting C and D grades over the last year, as he has had trouble concentrating and fallen asleep during exams numerous times. He denies changes in mood and has continued to sleep 8 hours per night and eat 3 meals per day recently. Which of the following medications will be most beneficial for this patient?
Psychotic Disorders US Medical PG Practice Questions and MCQs
Question 21: A 20-year-old woman is brought to the physician by her mother because she has been worried about her daughter's strange behavior for the past 2 years. She does not have any friends and spends most of her time alone in her room. She usually wears a long, black, hooded cloak. She is anxious at college because she is uncomfortable around other people, and her academic performance is poor. She collects rare crystals and says that they support her “sixth sense.” Mental status examination shows slow, hesitant speech, and she avoids eye contact. Which of the following is the most likely diagnosis?
A. Schizophrenia
B. Social anxiety disorder
C. Schizoid personality disorder
D. Schizotypal personality disorder (Correct Answer)
E. Paranoid personality disorder
Explanation: ***Schizotypal personality disorder***
- This disorder is characterized by **peculiar behaviors**, **odd beliefs (e.g., "sixth sense" and crystals)**, and **social anxiety** with discomfort in close relationships.
- The patient's social isolation, eccentric dress, and anxious behavior are consistent with **schizotypal traits**, which can include magical thinking and perceptual distortions.
*Schizophrenia*
- This condition involves significant **psychotic symptoms** such as **hallucinations, delusions**, and disorganized thought/speech, which are not explicitly described here.
- While schizotypal personality disorder can be a precursor, the patient's symptoms do not yet meet the full criteria for a psychotic episode.
*Social anxiety disorder*
- This disorder primarily involves an intense fear of social situations due to concerns about being judged or embarrassed.
- While social anxiety is present, the additional features of **odd beliefs** and **peculiar behaviors** are not typical of social anxiety disorder.
*Schizoid personality disorder*
- Individuals with schizoid personality disorder exhibit **detachment from social relationships** and a restricted range of emotional expression.
- However, they typically lack the **odd beliefs, eccentric behavior**, and social anxiety seen in schizotypal personality disorder.
*Paranoid personality disorder*
- Characterized by pervasive **distrust and suspiciousness of others**, often interpreting others' motives as malicious.
- This patient does not show evidence of paranoia or suspiciousness; her withdrawal is due to discomfort rather than mistrust.
Question 22: A 20-year-old male is involuntarily admitted to the county psychiatric unit for psychotic behavior over the past three months. The patient's mother explained to the psychiatrist that her son had withdrawn from family and friends, appeared to have no emotions, and had delusions that he was working for the CIA. When he spoke, his sentences did not always seem to have any connection with each other. The mother finally decided to admit her son after he began stating that he "revealed too much information to her and was going to be eliminated by the CIA." Which of the following diagnoses best fits this patient's presentation?
A. Schizophrenia
B. Brief psychotic disorder
C. Schizophreniform disorder (Correct Answer)
D. Schizoid personality disorder
E. Schizotypal personality disorder
Explanation: ***Schizophreniform disorder***
- The patient exhibits classic symptoms of **psychosis**, including delusions, disorganized speech, flat affect, and social withdrawal, which are characteristic of schizophrenia spectrum disorders.
- The duration of symptoms (3 months) fits the criteria for **schizophreniform disorder**, which is when psychotic symptoms last between 1 month and 6 months.
*Schizophrenia*
- Schizophrenia requires symptoms to be present for at least **6 months**, including at least 1 month of active-phase symptoms.
- While this patient's symptoms are consistent with psychotic disorder, the **duration criteria** for schizophrenia have not yet been met.
*Brief psychotic disorder*
- Brief psychotic disorder is characterized by symptoms lasting from **1 day to 1 month**, with eventual full return to premorbid functioning.
- The patient's symptoms have persisted for **3 months**, exceeding the maximum duration for brief psychotic disorder.
*Schizoid personality disorder*
- This disorder is characterized by a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression.
- While the patient exhibits social withdrawal, the presence of **delusions, disorganized speech, and flat affect** indicates a psychotic disorder, not merely a personality disorder.
*Schizotypal personality disorder*
- Schizotypal personality disorder involves pervasive social and interpersonal deficits with **cognitive or perceptual distortions** and eccentric behaviors.
- While it can involve odd beliefs, it does not typically include the prominent, fixed, and systematized **delusions and disorganized speech** seen in this patient's presentation.
Question 23: A 14-year-old boy is brought to the office by his step-parents because he was recently caught beating a stray cat in an alley near his home. He has a police record which includes vandalism, shoplifting, and running away on two occasions. He has also received several detentions and threats of expulsion from school due to bullying and being too aggressive with the younger students. Past medical history is significant for a history of ADHD previously treated with methylphenidate, but now he does not take anything. His biological family placed him and his sister into the foster care system. His step-parents try to provide support and nurturing home life but the patient is very resistant and often acts out. What is the most likely diagnosis for this patient?
A. Conduct disorder (Correct Answer)
B. Schizoid personality disorder
C. Antisocial personality disorder
D. Oppositional defiant disorder
E. Attention deficit hyperactivity disorder
Explanation: ***Conduct disorder***
- This patient exhibits a persistent pattern of behavior that **violates the basic rights of others** and **major age-appropriate societal norms**, including aggression to people and animals (beating a stray cat), destruction of property (vandalism), deceitfulness or theft (shoplifting), and serious violations of rules (running away, truancy due to bullying).
- The onset of these behaviors is before age 15, which is consistent with the diagnosis of **childhood-onset type conduct disorder**.
*Schizoid personality disorder*
- Characterized by a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression.
- This patient's behaviors, such as aggression and bullying, are indicative of active engagement with others (albeit negative), rather than social detachment.
*Antisocial personality disorder*
- This diagnosis requires the individual to be at least **18 years old** and to have a history of symptoms of conduct disorder before age 15.
- While the patient's behaviors are consistent with antisocial traits, he is currently **14 years old**, making antisocial personality disorder an inappropriate diagnosis at this time.
*Oppositional defiant disorder*
- Primarily involves a pattern of **angry/irritable mood**, **argumentative/defiant behavior**, or **vindictiveness**.
- While some features overlap, this patient's actions, such as beating an animal, vandalism, and shoplifting, go beyond mere defiance and constitute **serious violations of the rights of others** and major societal norms, which are characteristic of conduct disorder.
*Attention deficit hyperactivity disorder*
- Characterized by persistent patterns of **inattention**, **hyperactivity**, or **impulsivity**.
- While the patient has a history of ADHD, his current severe behaviors (e.g., animal cruelty, vandalism) signify a more pervasive disturbance involving aggression and rule-breaking, which are not core features of ADHD itself, but rather common comorbidities or a separate, more severe diagnosis like conduct disorder.
Question 24: At a counseling session, a 15-year-old boy recounts his childhood. He explained that his father was an angry, violent man who physically abused him and his younger brother every time he was drunk - which was almost every night. The boy said that the only way he could escape the situation was to believe that he himself was a superhero that would fight crime. Which of the following best describes the ego defense of this male?
A. Denial
B. Dissociation
C. Isolation of affect
D. Splitting
E. Fantasy (Correct Answer)
Explanation: ***Fantasy***
- This defense mechanism involves retreating into an **imaginary world** or scenario to escape from an unpleasant or difficult reality, as seen with the boy imagining himself as a superhero to cope with abuse.
- It allows an individual to avoid the pain and stress of their current situation by creating a more desirable internal experience.
*Denial*
- **Denial** involves refusing to acknowledge or accept a distressing reality, memory, or feeling.
- The boy is acknowledging the abuse but altering his perception of it, rather than flat-out denying it.
*Dissociation*
- **Dissociation** is a detachment from one's immediate surroundings, thoughts, memories, or identity, often in response to trauma.
- While he is escaping reality, his imaginative coping mechanism is more specifically "fantasy," which involves actively creating an imaginary world rather than a general detachment.
*Isolation of affect*
- This defense mechanism separates an unwanted thought or memory from the **emotion** associated with it, allowing the thought to remain conscious but without its painful emotional impact.
- The boy is not just isolating the feeling but is actively constructing an alternative reality.
*Splitting*
- **Splitting** involves viewing people or situations in extremes of all good or all bad, without integrating positive and negative qualities.
- This defense is not applicable here as the boy isn't dichotomizing his father or situation in an all-good/all-bad manner, but rather escaping the reality of the situation.
Question 25: A 27-year-old man is brought to the emergency department after he was found locked in a bathroom at a local gas station. The patient states that he was being followed. The patient is unable to reveal additional medical history due to his condition. The patient’s sister is contacted and states that he has trouble taking care of himself and has observed him maintaining a dialogue with what appears to be no one on several occasions. The patient’s temperature is 99.5°F (37.5°C), pulse is 90/min, blood pressure is 120/70 mmHg, respirations are 14/min, oxygen saturation is 98% on room air, and BMI is 22 kg/m^2. The patient is medicated and transferred to the inpatient psychiatric unit. The patient is kept there for three weeks and maintained on his medication regimen. Towards the end of his hospitalization, the patient is grooming himself properly, denies hearing voices, and no longer believes he is being followed. The patient’s temperature is 99.5°F (37.5°C), pulse is 80/min, blood pressure is 130/75 mmHg, respirations are 15/min, oxygen saturation is 98% on room air, and BMI is 24 kg/m^2. Which of the following medications was this patient most likely started on?
A. Ziprasidone
B. Risperidone
C. Olanzapine (Correct Answer)
D. Fluphenazine
E. Haloperidol
Explanation: ***Olanzapine***
- **Olanzapine** is associated with significant **weight gain**, which is reflected in the patient's BMI increase from 22 to 24 kg/m^2 over three weeks. This adverse effect is a key differentiator among antipsychotics.
- It is an **atypical antipsychotic** effective in treating positive symptoms (e.g., hallucinations, delusions) and negative symptoms of psychosis, as observed in the patient's improved condition.
*Ziprasidone*
- **Ziprasidone** is generally considered to be **weight-neutral** or associated with minimal weight gain, which contradicts the observed increase in the patient's BMI.
- It has a risk of **QT prolongation**, which is not indicated as a primary concern or differentiating factor in this case.
*Risperidone*
- While **risperidone** can cause weight gain, it is typically less pronounced in the short term compared to olanzapine. Its main distinguishing side effect is often **hyperprolactinemia**.
- It is also an effective antipsychotic but does not fit the rapid, significant weight gain pattern as strongly as olanzapine.
*Fluphenazine*
- **Fluphenazine** is a **first-generation (typical) antipsychotic** known for a higher risk of **extrapyramidal symptoms** (EPS) and less for significant weight gain, although some weight gain can occur.
- The patient's presentation does not strongly suggest an initial choice of a typical antipsychotic over an atypical one, given the potential for more severe side effects like EPS.
*Haloperidol*
- **Haloperidol** is another powerful **first-generation antipsychotic** often used for acute psychosis, notorious for its high incidence of **extrapyramidal symptoms** (e.g., dystonia, parkinsonism, akathisia).
- While it can cause some weight gain, it is less consistently associated with the substantial short-term weight gain observed in this patient compared to olanzapine.
Question 26: A 31-year-old woman is brought to the emergency department by EMS, activated by a bystander who found her wandering in the street. She provides short, vague answers to interview questions and frequently stops mid-sentence and stares at an empty corner of the room, appearing distracted. Her affect is odd but euthymic. Past medical history is notable for obesity and pre-diabetes. Collateral information from her brother reveals that she left home 3 days ago because she thought her family was poisoning her and has since been listed as a missing person. He also describes a progressive 2-year decline in her social interactions and self-care. The patient has no history of substance use and has never been prescribed psychiatric medications before but is amenable to starting a medication now. Which of the following would be the most appropriate as a first line medication for her?
A. Risperidone (Correct Answer)
B. Trazodone
C. Clomipramine
D. Olanzapine
E. Clozapine
Explanation: ***Risperidone***
- This patient presents with symptoms highly suggestive of **schizophrenia**, including **paranoid delusions** (family poisoning her), **disorganized thinking** (vague answers, stopping mid-sentence), **social withdrawal**, and decline in **self-care**. **Risperidone** is a **second-generation antipsychotic** and a common first-line treatment for schizophrenia due to its efficacy against both positive and negative symptoms.
- It is the **best choice among first-line antipsychotics** for this patient given her **obesity and pre-diabetes**, as it has a **lower risk of metabolic side effects** compared to olanzapine, while still maintaining excellent antipsychotic efficacy.
- The patient's **amenability to medication** and lack of prior treatment history make risperidone an ideal initial choice.
*Trazodone*
- **Trazodone** is an **antidepressant** primarily used for **major depressive disorder** and **insomnia**.
- It does not have significant **antipsychotic effects** and would not be effective in treating the delusions and disorganized thought processes seen in this patient.
*Clomipramine*
- **Clomipramine** is a **tricyclic antidepressant (TCA)** mainly used for **obsessive-compulsive disorder (OCD)** and severe depression.
- It is not indicated for psychotic disorders like schizophrenia and would not address the patient's **psychotic symptoms**.
*Olanzapine*
- While **olanzapine** is also a **second-generation antipsychotic** very effective for schizophrenia and considered first-line, the patient's history of **obesity** and **pre-diabetes** makes it a less ideal choice compared to risperidone.
- **Olanzapine** is associated with the **highest risk of metabolic side effects** among second-generation antipsychotics, including **weight gain**, **dyslipidemia**, and **new-onset diabetes**, which could significantly exacerbate her pre-existing conditions.
*Clozapine*
- **Clozapine** is a highly effective **antipsychotic**, but it is typically reserved for **treatment-resistant schizophrenia** due to its potentially severe side effects, including **agranulocytosis** and **myocarditis**.
- It requires **frequent blood monitoring** and is not considered a first-line agent, especially in a patient who has never received prior antipsychotic treatment.
Question 27: An 8-year-old boy is brought in by his mother who is concerned about her child’s behavior. She says his teachers have complained about him bullying other students at school, starting fights, and stealing other children’s lunch money. She also says that a neighbor down the street called her 6 months ago and reported that the patient had entered her yard and started viciously kicking her dog. He has no significant past medical history. He is in the 90th percentile for height and weight and has been meeting all developmental milestones. The patient is afebrile and his vital signs are within normal limits. Which of the following adult personality disorders does this patient’s diagnosis most likely predict?
A. Paranoid personality disorder
B. Schizotypal personality disorder
C. Schizoid personality disorder
D. Avoidant personality disorder
E. Antisocial personality disorder (Correct Answer)
Explanation: ***Antisocial personality disorder***
- The patient's presentation with a consistent pattern of violating the rights of others, including **bullying**, **fighting**, **stealing**, and **animal cruelty**, is highly indicative of **conduct disorder**.
- **Conduct disorder** in childhood is the most common precursor to developing **antisocial personality disorder** in adulthood.
*Paranoid personality disorder*
- This disorder is characterized by a pervasive **distrust and suspicion of others**, interpreting their motives as malicious, which is not indicated by the patient's behavior.
- While they may be hostile, their actions typically stem from perceived threats rather than direct aggression or disregard for others' rights as seen here.
*Schizotypal personality disorder*
- Individuals with schizotypal personality disorder exhibit **odd beliefs**, **magical thinking**, and **eccentric behavior** or appearance.
- They also tend to have **social anxiety** and difficulty forming close relationships, which doesn't align with the presented externalizing behaviors.
*Schizoid personality disorder*
- This disorder is characterized by a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression.
- There is no evidence of social withdrawal or uninterest in relationships; instead, the patient is actively engaging in harmful social interactions.
*Avoidant personality disorder*
- This disorder involves extreme **social inhibition**, feelings of inadequacy, and hypersensitivity to **negative evaluation**.
- The patient’s aggressive and non-compliant behaviors are contrary to the withdrawn and fearful nature seen in avoidant personality disorder.
Question 28: A 57-year-old man is brought to the physician for worsening mental status over the past 2 months. His wife reports he was initially experiencing lapses in memory and over the past 3 weeks he has begun having difficulties performing activities of daily living. Yesterday, he became lost heading to the post office down the street. He has hypertension treated with lisinopril and hydrochlorothiazide. Vital signs are within normal limits. He is alert but verbally uncommunicative. Muscle strength is normal. Reflexes are 2+ in bilateral upper and lower extremities. He has diffuse involuntary muscle jerking that can be provoked by loud noises. Mental status examination shows a blunt affect. A complete blood count and serum concentrations of glucose, creatinine, and electrolytes are within the reference range. Which of the following is the most likely diagnosis?
A. Parkinson's disease
B. Creutzfeldt-Jakob disease (Correct Answer)
C. Alzheimer's disease
D. Normal pressure hydrocephalus
E. Huntington's disease
Explanation: ***Creutzfeldt-Jakob disease***
- The rapid progression of **dementia**, combined with **myoclonus** (involuntary muscle jerking provoked by loud noises, also known as **startle myoclonus**), is highly characteristic of Creutzfeldt-Jakob disease (CJD).
- CJD is a **prion disease** that causes spongiform encephalopathy, leading to rapidly progressive neurologic decline over weeks to months, typically fatal within a year.
*Parkinson's disease*
- Characterized by a classic triad of **bradykinesia**, **rigidity**, and **resting tremor**, none of which are prominently described in this patient.
- While dementia can occur in later stages of Parkinson's, the **rapid progression** and presence of **myoclonus** are atypical.
*Alzheimer's disease*
- Presents with a **gradual onset** and **slow progression** of memory loss and cognitive decline, typically over many years, which contrasts with this patient's **2-month rapid deterioration**.
- **Myoclonus** is not a common early feature and the rate of progression is inconsistent with Alzheimer's.
*Normal pressure hydrocephalus*
- Classically presents with a triad of **gait disturbance**, **urinary incontinence**, and **dementia**; while dementia is present, the other two key features are not mentioned, and the progression is faster than typically seen.
- The characteristic **myoclonus** is not a feature of normal pressure hydrocephalus.
*Huntington's disease*
- Genetically inherited disorder characterized by **chorea** (involuntary, jerky movements) and psychiatric symptoms, followed by dementia.
- The onset is typically earlier (30s-40s) and the primary motor symptom is chorea, not the **startle myoclonus with rapid progression** observed here.
Question 29: A 10-year-old boy is brought to the physician by his parents because they are concerned about his “strange behavior”. The parents state that he has always been a lonely kid without many friends, but recently he has been having behavioral problems that seem to be unprovoked and are occurring more frequently. The child throws tantrums for no reason and does not respond to punishment or reward. He also has a “strange obsession” with collecting rocks that he finds on his way to and from school to the point where his room is filled with rocks. He plays alone in his room, lining the rocks up, organizing them by size, shape, or color, and he will randomly bark or make high-pitched noises without provocation. His teachers say he daydreams a lot and is very good at art, being able to recreate his favorite cartoon characters in great detail. On physical assessment, the patient does not make eye contact with the physician but talks incessantly about his rock collection. The child’s grammar and vocabulary seem normal but his speech is slightly labored, and he can’t seem to tell that the physician is not really interested in hearing about his rock collection. Which of the following is the most likely diagnosis?
A. Autism spectrum disorder (Correct Answer)
B. Obsessive-compulsive disorder
C. Tourette’s syndrome
D. Pick disease
E. Attention deficit hyperactivity disorder
Explanation: ***Autism spectrum disorder***
- This case presents classic features of **autism spectrum disorder (ASD)**, including **social deficits** (lonely, no friends, no eye contact, lack of awareness of others' interest), **repetitive behaviors and fixated interests** (rock collection, lining them up, organizing), and **stereotyped movements/vocalizations** (random barking, high-pitched noises).
- The child's excellent artistic skills and normal grammar/vocabulary despite other communication difficulties are also consistent with the varying presentations within the **autism spectrum**, which can include areas of exceptional talent alongside core deficits.
*Obsessive-compulsive disorder*
- While the rock collection and organizing might resemble an **obsession/compulsion**, OCD typically involves **intrusive thoughts (obsessions)** causing distress and **repetitive behaviors (compulsions)** performed to alleviate that distress.
- The presented social deficits, communication difficulties, and stereotyped movements are not characteristic of OCD alone.
*Tourette’s syndrome*
- **Tourette's syndrome** is characterized by **multiple motor tics** and **one or more vocal tics**. The barking and high-pitched noises could be tics, but Tourette's does not explain the profound social impairments, repetitive behaviors/interests, and communication difficulties described.
- The global pattern of symptoms points beyond Tourette's.
*Pick disease*
- **Pick disease** is a rare form of **frontotemporal dementia** that primarily affects adults, typically presenting with **personality changes**, **behavioral disinhibition**, and **language difficulties**.
- It is an adult-onset neurodegenerative disorder and would not be diagnosed in a 10-year-old child presenting with developmental differences.
*Attention deficit hyperactivity disorder*
- **ADHD** is characterized by **persistent patterns of inattention** and/or **hyperactivity-impulsivity**. While "daydreaming" could suggest inattention, the core features of social impairment, repetitive behaviors, and specific vocalizations are not typical of ADHD.
- The child's "strange obsession" and social isolation point away from a primary diagnosis of ADHD.
Question 30: A 21-year-old man presents to an outpatient psychiatrist with chief complaints of fatigue and “hearing voices.” He describes multiple voices which sometimes call his name or say nonsensical things to him before he falls asleep at night. He occasionally awakes to see “strange people” in his room, which frighten him but then disappear. The patient is particularly worried by this because his uncle developed schizophrenia when he was in his 20s. The patient also thinks he had a seizure a few days ago, saying he suddenly fell to the ground without warning, though he remembers the episode and denied any abnormal movements during it. He is in his 3rd year of college and used to be a top student, but has been getting C and D grades over the last year, as he has had trouble concentrating and fallen asleep during exams numerous times. He denies changes in mood and has continued to sleep 8 hours per night and eat 3 meals per day recently. Which of the following medications will be most beneficial for this patient?
A. Haloperidol
B. Valproic acid
C. Risperidone
D. Modafinil (Correct Answer)
E. Levetiracetam
Explanation: ***Modafinil***
- This patient presents with **narcolepsy**, characterized by the **classic tetrad**: excessive daytime sleepiness (falling asleep during exams), **cataplexy** (sudden fall without loss of consciousness or abnormal movements), **hypnagogic hallucinations** (hearing voices before sleep), and **hypnopompic hallucinations** (seeing people upon awakening).
- The hallucinations are **not true psychotic symptoms** but rather dream-like phenomena occurring at sleep-wake transitions, which are common in narcolepsy.
- **Modafinil** is a first-line **wakefulness-promoting agent** that treats the excessive daytime sleepiness and improves alertness, addressing the primary pathology.
- The patient's family history of schizophrenia is a red herring; his symptoms are explained by narcolepsy, not a primary psychotic disorder.
*Risperidone*
- Risperidone is an **atypical antipsychotic** used for schizophrenia and other psychotic disorders.
- This patient does **not have a primary psychotic disorder**—the hallucinations are hypnagogic/hypnopompic phenomena associated with narcolepsy, not true psychotic hallucinations.
- Using an antipsychotic would be inappropriate and could **worsen daytime sleepiness** due to sedating effects, exacerbating the patient's core problem.
*Haloperidol*
- Haloperidol is a **first-generation antipsychotic** with significant risk of **extrapyramidal side effects**.
- Like risperidone, it would be inappropriate here as the patient does not have a psychotic disorder, and it would worsen sedation and daytime sleepiness.
*Valproic acid*
- Valproic acid is a **mood stabilizer and anticonvulsant** used for bipolar disorder and seizure disorders.
- The described "seizure" event is actually **cataplexy** (preserved consciousness, no abnormal movements), not a true seizure, so an anticonvulsant is not indicated.
- It would not address the narcolepsy symptoms and can cause sedation.
*Levetiracetam*
- Levetiracetam is an **anticonvulsant** medication.
- The patient's description (remembering the episode, no abnormal movements) is inconsistent with a seizure and consistent with **cataplexy**, which is treated by addressing the underlying narcolepsy, not with anticonvulsants.