A 21-year-old nurse starts to feel ill during his evening shift. Earlier this evening, he started his shift in his normal state of health. Past medical history is significant for multiple admissions to the hospital under strange circumstances. One time he presented to the emergency department complaining of severe abdominal pain and gallstones, though no stones were identified and he was discharged after a full workup. Another time he was admitted for recurrent vomiting episodes and he was discharged after an EGD and several rounds of antiemetics. He has also visited an outpatient clinic for back pain and knee pain, though no findings were ever identified. He takes a multivitamin every day. His mother developed breast cancer at 47 and his father is healthy. Today, his blood pressure is 120/80 mm Hg, heart rate is 105/min, respiratory rate is 17/min, and temperature is 36.9°C (98.4°F). On physical exam, he appears thin and anxious. He is diaphoretic with clammy hands. His heart is tachycardic with an irregular rhythm and his lungs are clear to auscultation bilaterally. A urine toxicology test and EKG are negative. Random blood sugar is 45 mg/dL. The nurse is admitted and treated appropriately. After a thorough review of his medical records, the hospitalist assigned to this patient consults with psychiatry because she is concerned the patient may have factitious disorder. Which of the following would confirm a diagnosis of the factitious disorder in this patient?
Q12
A 21-year-old woman is brought to the clinic for evaluation by her brother. The patient’s brother says that, 3 days ago, the patient had put on her best pantsuit and makeup and insisted that she was returning to work and driving to Seattle to take over for the CEO of the Amazon Corporation. He says this was especially odd because her husband was just killed in an automobile accident in a different city 2 days ago. Today, the patient’s brother says she was saddened, wearing grey jogging pants. The patient says she does not recall acting odd and does remember that her husband is dead. Her vital signs include: blood pressure 132/84 mm Hg, pulse 92/min, respiratory rate 16/min, temperature 37.4°C (99.4°F). Upon physical examination, the patient’s affect is saddened but her speech rate and volume are normal. There is no hallucinations, mania, interruptive speech, depressive symptoms, or loss of interest in activities once enjoyed. Results of urine drug screen are provided below:
Amphetamine negative
Benzodiazepine negative
Cocaine negative
GHB negative
Ketamine negative
LSD negative
Marijuana negative
Opioids negative
PCP negative
Which of the following best describes the patient’s state?
Q13
A mother brings her 4-year-old son to his pediatrician. Over the last eight months, her son has been exhibiting several "odd" behaviors. Most importantly, he repeatedly says that he is playing games with a friend named "Steven," though she is certain that he does not exist. She has often found him acting out magical scenarios as though someone else is present, when no one is there. What is the most likely diagnosis in this patient?
Q14
A 45-year-old man presents to a psychiatrist by his wife with recent behavioral and emotional changes. The patient’s wife says that her husband’s personality has completely changed over the last year. She also says that he often complains of unpleasant odors when actually there is no discernible odor present. The patient mentions that he is depressed at times while on other occasions, he feels like he is ‘the most powerful man in the world.’ The psychiatrist takes a detailed history from this patient and concludes that he is most likely suffering from a psychotic disorder. However, before prescribing an antipsychotic medication, he recommends that the patient undergoes brain imaging to rule out a brain neoplasm. Based on the presence of which of the following clinical signs or symptoms in this patient is the psychiatrist most likely recommending this imaging test?
Q15
A 23-year-old man is brought to the emergency department by his girlfriend because of acute agitation and bizarre behavior. The girlfriend reports that, over the past 3 months, the patient has become withdrawn and stopped pursuing hobbies that he used to enjoy. One month ago, he lost his job because he stopped going to work. During this time, he has barely left his apartment because he believes that the FBI is spying on him and controlling his mind. He used to smoke marijuana occasionally in high school but quit 5 years ago. Physical and neurologic examinations show no abnormalities. On mental status examination, he is confused and suspicious with marked psychomotor agitation. His speech is disorganized and his affect is labile. Which of the following is the most likely diagnosis?
Q16
A 21-year-old man is brought to the office by his parents due to concerns about his behavior. They describe their son as aloof and a loner who earns average to below average grades in school. Today, his heart rate is 90/min, respiratory rate is 17/min, blood pressure is 110/65 mm Hg, and temperature is 36.8°C (98.2°F). On physical examination, he appears gaunt and anxious. His heart has a regular rhythm, and his lungs are clear to auscultation bilaterally. CMP, CBC, and TSH are normal. A urine toxicology test is negative. During the examination, he avoids eye contact and appears detached. When asked about his social life, he claims that he does not care about making friends and prefers to be alone. He says he enjoys going to the movies, but he enjoys doing this alone. He has not had a romantic partner before and takes little pleasure in intimacy. He denies experiencing hallucinations or delusions. Which of the following is the most likely diagnosis?
Q17
A 27-year-old female is brought to the Emergency Department by Fire Rescue after participating in a physical altercation with several commuters on the subway. She appears to be responding to hallucinations and is diaphoretic. Her vitals are as follows: T 100.5F (38C), HR 115, BP 155/90, RR 17. Her past medical history is notable for a previous ED visit for phencyclidine-related agitation. Which of the following physical findings would most strongly suggest the same diagnosis?
Q18
A 35-year-old male with a history of repeated arrests for assault, robbery, and arson displays a callous disregard for the safety of others and a lack of remorse, as evidenced by smiling when questioned about burning down his ex-girlfriend's apartment. Considering a diagnosis of antisocial personality disorder, which of the following behaviors was most likely present during his childhood?
Q19
A 26-year-old woman is brought to the emergency department by her husband due to her disturbing behavior over the past 24 hours. Her husband says that he has noticed his wife talking to herself and staying in a corner of a room throughout the day without eating or drinking anything. She gave birth to their son 2 weeks ago but has not seen or even acknowledged her baby’s presence ever since he was born. He says that he didn’t think much of it because she seemed overwhelmed during her pregnancy and he considered that she was probably unable to cope with being a new mother; however, last night, he says, his wife told him that their child was the son of the devil and they ought to get rid of him as soon as possible. Which of the following describes this patient’s abnormal reaction to her child?
Q20
A 28-year-old G1P1 woman is brought into the clinic by her concerned husband. The husband has noted that his wife is not behaving normally. She no longer enjoys his company or is not particularly happy around their newborn. The newborn was delivered 3 weeks ago via normal vaginal delivery with no complications. He also notes that his wife seems to be off in some other world with her thoughts. Overall, she appears to be drained, and her movements and speech seem slow. The patient complains that the newborn is sucking the lifeforce from her when she breastfeeds. She has thus stopped eating to save herself from this parasite. Which of the following statements is true regarding this patient’s most likely condition?
Psychotic Disorders US Medical PG Practice Questions and MCQs
Question 11: A 21-year-old nurse starts to feel ill during his evening shift. Earlier this evening, he started his shift in his normal state of health. Past medical history is significant for multiple admissions to the hospital under strange circumstances. One time he presented to the emergency department complaining of severe abdominal pain and gallstones, though no stones were identified and he was discharged after a full workup. Another time he was admitted for recurrent vomiting episodes and he was discharged after an EGD and several rounds of antiemetics. He has also visited an outpatient clinic for back pain and knee pain, though no findings were ever identified. He takes a multivitamin every day. His mother developed breast cancer at 47 and his father is healthy. Today, his blood pressure is 120/80 mm Hg, heart rate is 105/min, respiratory rate is 17/min, and temperature is 36.9°C (98.4°F). On physical exam, he appears thin and anxious. He is diaphoretic with clammy hands. His heart is tachycardic with an irregular rhythm and his lungs are clear to auscultation bilaterally. A urine toxicology test and EKG are negative. Random blood sugar is 45 mg/dL. The nurse is admitted and treated appropriately. After a thorough review of his medical records, the hospitalist assigned to this patient consults with psychiatry because she is concerned the patient may have factitious disorder. Which of the following would confirm a diagnosis of the factitious disorder in this patient?
A. Elevated troponin I and CK-MB levels
B. Presence of norepinephrine and vanillylmandelic acid in the urine
C. Increased c-peptide levels
D. Low c-peptide levels (Correct Answer)
E. Increased anion gap
Explanation: ***Low c-peptide levels***
- The patient presents with **hypoglycemia** (blood sugar 45 mg/dL) and symptoms like anxiety, diaphoresis, and tachycardia that suggest an acute insulin-induced event.
- **Low C-peptide levels** in the presence of hypoglycemia indicate that the insulin is exogenous (injected) rather than naturally produced by the body, as C-peptide is co-secreted with endogenous insulin. This manipulation for secondary gain is characteristic of **factitious disorder**.
*Elevated troponin I and CK-MB levels*
- These markers are indicative of **myocardial injury** or **ischemia**, which is not directly suggested by the patient's presentation or typical for factitious disorder unless used as an elaborate means to feign a heart attack.
- While the patient has tachycardia and an irregular rhythm, a negative EKG makes acute cardiac injury less likely as the primary concern for diagnosing factitious disorder in this scenario.
*Presence of norepinephrine and vanillylmandelic acid in the urine*
- Elevated levels of these catecholamine metabolites would suggest a **pheochromocytoma**, a tumor of the adrenal medulla causing excessive catecholamine release.
- The patient's symptoms (tachycardia, anxiety, diaphoresis) could overlap with pheochromocytoma, but the primary acute finding of **hypoglycemia** is not characteristic of this condition.
*Increased c-peptide levels*
- **High C-peptide levels** in the presence of hypoglycemia would indicate **endogenous hyperinsulinism**, such as from an insulinoma or sulfonylurea overdose.
- While this suggests an internal cause of excess insulin production, it would contradict the hypothesis of injected insulin for factitious disorder, making it an unlikely finding in this context.
*Increased anion gap*
- An **increased anion gap** is typically seen in metabolic acidosis, caused by conditions like lactic acidosis, diabetic ketoacidosis, or toxic ingestions (e.g., methanol, ethylene glycol).
- Although the patient is acutely ill, an increased anion gap is not directly implicated in the diagnosis of factitious disorder related to insulin administration.
Question 12: A 21-year-old woman is brought to the clinic for evaluation by her brother. The patient’s brother says that, 3 days ago, the patient had put on her best pantsuit and makeup and insisted that she was returning to work and driving to Seattle to take over for the CEO of the Amazon Corporation. He says this was especially odd because her husband was just killed in an automobile accident in a different city 2 days ago. Today, the patient’s brother says she was saddened, wearing grey jogging pants. The patient says she does not recall acting odd and does remember that her husband is dead. Her vital signs include: blood pressure 132/84 mm Hg, pulse 92/min, respiratory rate 16/min, temperature 37.4°C (99.4°F). Upon physical examination, the patient’s affect is saddened but her speech rate and volume are normal. There is no hallucinations, mania, interruptive speech, depressive symptoms, or loss of interest in activities once enjoyed. Results of urine drug screen are provided below:
Amphetamine negative
Benzodiazepine negative
Cocaine negative
GHB negative
Ketamine negative
LSD negative
Marijuana negative
Opioids negative
PCP negative
Which of the following best describes the patient’s state?
A. Schizoaffective disorder
B. Brief psychotic disorder (Correct Answer)
C. Schizoid personality disorder
D. Schizotypal personality disorder
E. Borderline personality disorder
Explanation: ***Brief psychotic disorder***
- The patient experienced a sudden, short-lived period of **psychotic symptoms** (delusions about taking over Amazon CEO) immediately following a significant stressor (husband's death).
- Her current state shows resolution of these symptoms and lack of criteria for other mood or psychotic disorders, consistent with the definition of **brief psychotic disorder** (symptoms lasting less than 1 month).
*Schizoaffective disorder*
- This disorder involves a continuous period where an individual experiences both a **major mood episode (depressive or manic)** and **psychotic symptoms** (e.g., delusions, hallucinations) simultaneously.
- The patient's psychotic episode was brief and resolved, and she does not currently exhibit criteria for a major mood episode or ongoing psychotic symptoms.
*Schizoid personality disorder*
- Characterized by a pervasive pattern of **detachment from social relationships** and a restricted range of expression of emotions in interpersonal settings.
- This patient's acute, short-lived psychotic symptoms, followed by recovery, do not align with the chronic, pervasive nature of a personality disorder.
*Schizotypal personality disorder*
- Involves a pervasive pattern of **social and interpersonal deficits** marked by acute discomfort with, and reduced capacity for, close relationships, as well as **cognitive or perceptual distortions** and eccentricities of behavior.
- The patient's presentation was an acute, time-limited psychotic episode, not a persistent pattern of odd thoughts, behaviors, and social deficits characteristic of schizotypal personality disorder.
*Borderline personality disorder*
- Defined by a pervasive pattern of **instability of interpersonal relationships, self-image, and affects**, and marked impulsivity.
- While individuals with borderline personality disorder can experience transient, stress-related psychotic-like symptoms, the primary features of severe mood dysregulation, unstable relationships, and identity disturbance are not described.
Question 13: A mother brings her 4-year-old son to his pediatrician. Over the last eight months, her son has been exhibiting several "odd" behaviors. Most importantly, he repeatedly says that he is playing games with a friend named "Steven," though she is certain that he does not exist. She has often found him acting out magical scenarios as though someone else is present, when no one is there. What is the most likely diagnosis in this patient?
A. Schizophreniform disorder
B. Schizophrenia
C. Developmental delay
D. Schizoid personality disorder
E. Normal development (Correct Answer)
Explanation: ***Normal development***
- It is **normal for children** between the ages of 3-7 to have **imaginary friends** or engage in imaginary play, which supports **creativity** and **social development**.
- There is no indication of distress, functional impairment, or other diagnostic criteria for a mental disorder, making this a typical developmental phenomenon.
*Schizophreniform disorder*
- This disorder is characterized by symptoms of schizophrenia lasting **between 1 and 6 months**; the child's age makes a diagnosis of schizophrenia or schizophreniform disorder highly unlikely.
- While it involves psychotic symptoms such as **hallucinations** or **delusions**, the described behaviors of an imaginary friend and magical thinking are not psychotic in a 4-year-old.
*Schizophrenia*
- Schizophrenia is rare in children and typically involves more pervasive and severe symptoms such as **prominent delusions**, **frank hallucinations**, **disorganized speech**, and **negative symptoms** causing significant functional impairment.
- The behavior described is consistent with a normal developmental stage, not the severe and persistent psychotic symptoms required for a schizophrenia diagnosis.
*Developmental delay*
- Developmental delay implies a significant lag in reaching developmental milestones across various domains (e.g., cognitive, social, motor).
- The child's behaviors are within the range of **typical development** for imaginary play, and there is no information to suggest a global delay in other areas.
*Schizoid personality disorder*
- This is a personality disorder typically diagnosed in **adulthood**, characterized by a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression.
- This child's behavior of having an imaginary friend suggests active engagement in a form of social interaction and creativity, which contradicts the features of social detachment seen in schizoid personality disorder.
Question 14: A 45-year-old man presents to a psychiatrist by his wife with recent behavioral and emotional changes. The patient’s wife says that her husband’s personality has completely changed over the last year. She also says that he often complains of unpleasant odors when actually there is no discernible odor present. The patient mentions that he is depressed at times while on other occasions, he feels like he is ‘the most powerful man in the world.’ The psychiatrist takes a detailed history from this patient and concludes that he is most likely suffering from a psychotic disorder. However, before prescribing an antipsychotic medication, he recommends that the patient undergoes brain imaging to rule out a brain neoplasm. Based on the presence of which of the following clinical signs or symptoms in this patient is the psychiatrist most likely recommending this imaging test?
A. Olfactory hallucinations (Correct Answer)
B. Echolalia
C. Anhedonia
D. Delusions of grandeur
E. Thought broadcasting
Explanation: ***Olfactory hallucinations***
- The presence of **olfactory hallucinations** ("unpleasant odors when actually there is no discernible odor present") in the context of new-onset psychotic symptoms and personality changes, particularly in a middle-aged adult, raises suspicion for an underlying **structural brain lesion**, such as a **frontal or temporal lobe tumor**.
- Brain neoplasms in these regions can irritate cortical areas, leading to atypical psychotic symptoms and these specific types of hallucinations, making imaging crucial before initiating antipsychotic therapy.
*Echolalia*
- **Echolalia** is the involuntary repetition of words or phrases spoken by another person, often associated with conditions like **autism spectrum disorder**, **Tourette's syndrome**, or severe **psychotic disorders**, particularly **schizophrenia**.
- While it can be a feature of psychiatric illness, it is not a red flag for structural brain pathology in the same manner as new-onset olfactory hallucinations.
*Anhedonia*
- **Anhedonia** is the inability to experience pleasure from activities usually found enjoyable, a prominent symptom of **major depressive disorder** and other mood disorders, as well as some psychotic disorders.
- Although the patient reports feeling "depressed at times," anhedonia is a common psychiatric symptom and does not specifically point to a need for urgent brain imaging in the absence of other alarming features.
*Delusions of grandeur*
- **Delusions of grandeur** are false beliefs that one is much greater or more powerful than they truly are, as described by the patient feeling like "the most powerful man in the world." This symptom is characteristic of **bipolar disorder (manic episodes)** or some **psychotic disorders**.
- While present in this patient, grandiose delusions are part of the core symptomatology of many psychiatric conditions and, by themselves, do not typically necessitate brain imaging to rule out a tumor.
*Thought broadcasting*
- **Thought broadcasting** is the belief that one's thoughts are being transmitted into the minds of others, a classic **first-rank symptom of schizophrenia**.
- This symptom is indicative of a severe thought disorder within the spectrum of psychotic illnesses but does not specifically raise the suspicion of an underlying brain lesion requiring neuroimaging.
Question 15: A 23-year-old man is brought to the emergency department by his girlfriend because of acute agitation and bizarre behavior. The girlfriend reports that, over the past 3 months, the patient has become withdrawn and stopped pursuing hobbies that he used to enjoy. One month ago, he lost his job because he stopped going to work. During this time, he has barely left his apartment because he believes that the FBI is spying on him and controlling his mind. He used to smoke marijuana occasionally in high school but quit 5 years ago. Physical and neurologic examinations show no abnormalities. On mental status examination, he is confused and suspicious with marked psychomotor agitation. His speech is disorganized and his affect is labile. Which of the following is the most likely diagnosis?
A. Schizophreniform disorder (Correct Answer)
B. Schizoid personality disorder
C. Delusional disorder
D. Schizoaffective disorder
E. Brief psychotic disorder
Explanation: **Correct: Schizophreniform disorder**
- This patient presents with ***psychotic symptoms*** (delusions, disorganized speech, agitation) and ***negative symptoms*** (withdrawal, anhedonia, loss of job), which have been present for approximately ***3 months***.
- The ***duration of symptoms (1-6 months)*** is the key differentiating factor for schizophreniform disorder compared to brief psychotic disorder (<1 month) or schizophrenia (>6 months).
- Meets DSM-5 criteria: psychotic symptoms with functional impairment lasting between 1 and 6 months.
*Incorrect: Schizoid personality disorder*
- Characterized by a pervasive pattern of ***detachment from social relationships*** and a restricted range of emotional expression, which are ***ego-syntonic*** and typically stable over time.
- This is a personality disorder with chronic traits, not an acute psychotic disorder.
- Does not include acute psychotic symptoms like delusions or disorganized speech.
*Incorrect: Delusional disorder*
- Defined by the presence of ***non-bizarre delusions*** for at least one month, without other significant psychotic symptoms or major functional impairment.
- This patient has ***bizarre delusions*** (FBI controlling his mind), ***disorganized speech***, ***psychomotor agitation***, and ***marked functional impairment***, which exceed the criteria for delusional disorder.
*Incorrect: Schizoaffective disorder*
- Requires the presence of a ***major mood episode*** (depressive or manic) concurrent with symptoms of schizophrenia, AND ***delusions or hallucinations for at least 2 weeks*** in the absence of a major mood episode.
- While the patient exhibits labile affect, there is no evidence of a distinct, prolonged major mood episode (major depression or mania) as required for schizoaffective disorder.
*Incorrect: Brief psychotic disorder*
- Characterized by the sudden onset of psychotic symptoms (delusions, hallucinations, disorganized speech or behavior) that last for ***at least one day but less than one month***, followed by full return to premorbid functioning.
- The patient's symptoms have been ongoing for approximately ***3 months***, which exceeds the duration criteria for brief psychotic disorder.
Question 16: A 21-year-old man is brought to the office by his parents due to concerns about his behavior. They describe their son as aloof and a loner who earns average to below average grades in school. Today, his heart rate is 90/min, respiratory rate is 17/min, blood pressure is 110/65 mm Hg, and temperature is 36.8°C (98.2°F). On physical examination, he appears gaunt and anxious. His heart has a regular rhythm, and his lungs are clear to auscultation bilaterally. CMP, CBC, and TSH are normal. A urine toxicology test is negative. During the examination, he avoids eye contact and appears detached. When asked about his social life, he claims that he does not care about making friends and prefers to be alone. He says he enjoys going to the movies, but he enjoys doing this alone. He has not had a romantic partner before and takes little pleasure in intimacy. He denies experiencing hallucinations or delusions. Which of the following is the most likely diagnosis?
A. Avoidant personality disorder
B. Schizoid personality disorder (Correct Answer)
C. Major depressive disorder
D. Autism spectrum disorder
E. Schizotypal personality disorder
Explanation: ***Schizoid personality disorder***
- The patient's **detachment from social relationships**, **restricted range of emotional expression**, and indifference to praise or criticism are characteristic features. He actively *prefers* to be alone and "does not care about making friends."
- His lack of desire for intimacy, preference for solitary activities like going to movies alone, and reports of taking **little pleasure in intimacy**, align with the diagnostic criteria.
*Avoidant personality disorder*
- Individuals with avoidant personality disorder *desire* social connections but **avoid them due to fear of rejection** or criticism, which is not described in this patient.
- This patient explicitly states he "does not care about making friends" and "prefers to be alone," indicating a lack of desire rather than fear.
*Major depressive disorder*
- While **anhedonia** (loss of pleasure) can be a symptom of depression, the chronic and pervasive nature of his social detachment and emotional blunting, starting in adolescence, points away from an episodic mood disorder.
- There are no other common symptoms of depression such as changes in sleep, appetite, energy, or feelings of worthlessness, nor does he report dysphoria.
*Autism spectrum disorder*
- Although there is some overlap in symptoms like **social aloofness** and restricted interests, autism spectrum disorder typically involves **deficits in nonverbal communication** and often repetitive behaviors or highly restricted, fixated interests.
- The patient's social presentation primarily revolves around a *lack of desire* for social connection rather than an *impairment in capacity* for social interaction.
*Schizotypal personality disorder*
- Schizotypal personality disorder involves **eccentric behavior**, **peculiar thought patterns**, and perceptual distortions (e.g., magical thinking, ideas of reference), and often odd speech.
- The patient denies experiencing hallucinations or delusions, and his presentation does not include the characteristic cognitive or perceptual distortions seen in schizotypal personality disorder.
Question 17: A 27-year-old female is brought to the Emergency Department by Fire Rescue after participating in a physical altercation with several commuters on the subway. She appears to be responding to hallucinations and is diaphoretic. Her vitals are as follows: T 100.5F (38C), HR 115, BP 155/90, RR 17. Her past medical history is notable for a previous ED visit for phencyclidine-related agitation. Which of the following physical findings would most strongly suggest the same diagnosis?
A. Conjunctival injection
B. Dilated, minimally responsive pupils
C. Prominent vertical nystagmus (Correct Answer)
D. Constricted but responsive pupils
E. Conjunctival pallor
Explanation: ***Prominent vertical nystagmus***
- **Vertical nystagmus** is a classic and highly suggestive finding in **phencyclidine (PCP) intoxication**, distinguishing it from other stimulant or hallucinogenic drug effects.
- PCP directly affects the cerebellar and vestibular systems, leading to unique oculomotor disturbances including both horizontal and vertical forms of nystagmus, though vertical is particularly indicative.
*Conjunctival injection*
- While sometimes seen in drug intoxication, **conjunctival injection** is more commonly associated with **cannabis use** or other irritants and is not specific to PCP.
- This finding does not provide strong diagnostic evidence for PCP, as it can occur in various conditions.
*Dilated, minimally responsive pupils*
- **Mydriasis (dilated pupils)** can be observed with various stimulant and hallucinogenic drugs, including PCP, due to sympathetic nervous system activation.
- However, the descriptor "minimally responsive" is less specific to PCP and could be seen in other severe intoxications or neurological impairments.
*Constricted but responsive pupils*
- **Constricted pupils (miosis)** are typically associated with **opioid intoxication** or certain cholinergic agents, not PCP.
- This finding would strongly argue against PCP use.
*Conjunctival pallor*
- **Conjunctival pallor** suggests **anemia** or reduced blood flow, and is not a common or specific finding in drug intoxications.
- It would not support a diagnosis of PCP intoxication in this context.
Question 18: A 35-year-old male with a history of repeated arrests for assault, robbery, and arson displays a callous disregard for the safety of others and a lack of remorse, as evidenced by smiling when questioned about burning down his ex-girlfriend's apartment. Considering a diagnosis of antisocial personality disorder, which of the following behaviors was most likely present during his childhood?
A. Fear of abandonment
B. Bed-wetting
C. Odd beliefs
D. Conduct disorder behaviors (Correct Answer)
E. Perfectionist
Explanation: ***Conduct disorder behaviors***
- A diagnosis of **antisocial personality disorder** in adulthood requires a history of **conduct disorder** onset before age 15.
- Behaviors such as **aggression towards people and animals**, **destruction of property**, **deceitfulness or theft**, and **serious violations of rules** are characteristic of conduct disorder and often precede ASPD.
*Fear of abandonment*
- This symptom is characteristic of **borderline personality disorder**, which involves instability in relationships, self-image, and emotions, and is not typically associated with ASPD.
- Individuals with borderline personality disorder often engage in frantic efforts to avoid real or imagined abandonment.
*Bed-wetting*
- While sometimes associated with childhood trauma or psychological distress, **enuresis (bed-wetting)** is not a specific diagnostic criterion or a strong predictor of antisocial personality disorder.
- It does not directly reflect the core patterns of disregard for others or rule-breaking that define the developmental trajectory of ASPD.
*Odd beliefs*
- **Odd beliefs** are more indicative of **schizotypal personality disorder**, which involves eccentric behavior, cognitive or perceptual distortions, and discomfort with close relationships.
- These beliefs are not a typical feature in the developmental history of antisocial personality disorder.
*Perfectionist*
- **Perfectionism** is a central characteristic of **obsessive-compulsive personality disorder (OCPD)**, marked by a preoccupation with orderliness, control, and details to the extent of rigid and inflexible behavior.
- This trait is contrary to the impulsive and disregardful nature seen in individuals with antisocial personality disorder.
Question 19: A 26-year-old woman is brought to the emergency department by her husband due to her disturbing behavior over the past 24 hours. Her husband says that he has noticed his wife talking to herself and staying in a corner of a room throughout the day without eating or drinking anything. She gave birth to their son 2 weeks ago but has not seen or even acknowledged her baby’s presence ever since he was born. He says that he didn’t think much of it because she seemed overwhelmed during her pregnancy and he considered that she was probably unable to cope with being a new mother; however, last night, he says, his wife told him that their child was the son of the devil and they ought to get rid of him as soon as possible. Which of the following describes this patient’s abnormal reaction to her child?
A. Brief psychotic disorder
B. Schizoaffective disorder
C. Postpartum psychosis (Correct Answer)
D. Major depressive disorder
E. Postpartum blues
Explanation: **Postpartum psychosis**
- This patient exhibits **psychotic symptoms** (delusions about the child, hallucinations like talking to herself) and **severe disorganization** (staying in a corner, not eating/drinking, neglecting her baby) within two weeks postpartum.
- This severe and acute onset of psychosis in the **postpartum period** is characteristic of postpartum psychosis, which is a medical emergency requiring immediate intervention.
*Brief psychotic disorder*
- While it involves psychotic symptoms of acute onset and short duration (less than one month), this diagnosis typically applies when symptoms are not directly attributable to a specific precipitating factor like childbirth.
- The clear temporal association with childbirth in this case makes postpartum psychosis a more specific and accurate diagnosis.
*Schizoaffective disorder*
- This disorder typically involves a combination of **mood symptoms** (depressive or manic) and **psychotic symptoms**, where psychotic symptoms are present for at least two weeks in the absence of a major mood episode.
- The sudden onset and direct link to the postpartum period distinguish this case from schizoaffective disorder, which usually has a more chronic or episodic course.
*Major depressive disorder*
- Although the patient shows signs of severe withdrawal and neglect, the presence of **frank psychotic symptoms** (delusions about the child being the "son of the devil") goes beyond the typical presentation of major depressive disorder, even with psychotic features.
- While depression can coexist, the predominant and acute psychotic features point more directly to postpartum psychosis.
*Postpartum blues*
- Postpartum blues are **mild and transient mood disturbances** (tearfulness, irritability, anxiety) occurring in the first few days to two weeks postpartum, typically resolving on their own.
- The patient's symptoms are far more severe, involving **psychotic delusions and severe functional impairment**, making postpartum blues an inadequate diagnosis.
Question 20: A 28-year-old G1P1 woman is brought into the clinic by her concerned husband. The husband has noted that his wife is not behaving normally. She no longer enjoys his company or is not particularly happy around their newborn. The newborn was delivered 3 weeks ago via normal vaginal delivery with no complications. He also notes that his wife seems to be off in some other world with her thoughts. Overall, she appears to be drained, and her movements and speech seem slow. The patient complains that the newborn is sucking the lifeforce from her when she breastfeeds. She has thus stopped eating to save herself from this parasite. Which of the following statements is true regarding this patient’s most likely condition?
A. Risk for this patient’s condition increases with each pregnancy
B. Ziprasidone is the first-line pharmacotherapy recommended for this patient’s condition
C. This patient’s condition is self-limited
D. Electroconvulsive therapy is the first-line therapy for this patient’s condition
E. If symptoms present within a month after delivery and treatment occurs promptly, the prognosis is good (Correct Answer)
Explanation: ***If symptoms present within a month after delivery and treatment occurs promptly, the prognosis is good***
- This patient presents with symptoms highly suggestive of **postpartum psychosis**, including **delusions** (**newborn sucking lifeforce**), **disorganized thoughts**, **psychomotor retardation**, and **mood lability**, which developed rapidly after childbirth. Prompt identification and treatment of postpartum psychosis, especially when symptoms manifest early, leads to a **good prognosis** for recovery.
- Early intervention significantly reduces the risk of harm to the mother or infant and improves long-term outcomes, with many women achieving full remission.
*Risk for this patient’s condition increases with each pregnancy*
- The risk of **postpartum psychosis** is primarily associated with a **history of bipolar disorder** or a previous episode of postpartum psychosis, not simply the number of pregnancies.
- While it can recur, it does not inherently increase with each subsequent pregnancy in the absence of other risk factors.
*Ziprasidone is the first-line pharmacotherapy recommended for this patient’s condition*
- While **antipsychotics** like ziprasidone are part of the treatment for postpartum psychosis, **lithium** is often considered a first-line agent, particularly when there is a significant mood component or history of bipolar disorder.
- The initial management often involves hospitalization, mood stabilizers, and antipsychotics, with the choice of medication tailored to the individual's symptoms and history.
*This patient’s condition is self-limited*
- **Postpartum psychosis** is a severe psychiatric emergency that is **not self-limited** and requires urgent medical intervention.
- Without treatment, it carries a significant risk of harm to both the mother and the infant, including infanticide or suicide.
*Electroconvulsive therapy is the first-line therapy for this patient’s condition*
- **Electroconvulsive therapy (ECT)** is a highly effective treatment for severe postpartum psychosis, especially in cases of **catatonia**, severe mood symptoms, or when there is an inadequate response to medication, but it is typically reserved for **severe or refractory cases** rather than being the absolute first-line therapy.
- Initial treatment usually involves pharmacotherapy (e.g., antipsychotics and mood stabilizers) and often hospitalization for safety reasons.