A 9-year-old boy is brought to a pediatric psychologist by his mother because of poor academic performance. The patient’s mother mentions that his academic performance was excellent in kindergarten and first grade, but his second and third-grade teachers complain that he is extremely talkative, does not complete schoolwork, and frequently makes careless mistakes. They also complain that he frequently looks at other students or outside the window during the class and is often lost during the lessons. At home, he is very talkative and disorganized. When the pediatrician asks the boy his name, he replies promptly. He was born at full term by spontaneous vaginal delivery. He is up-to-date on all vaccinations and has met all developmental milestones on time. A recent IQ test scored him at 95. His physical examination is completely normal. When he is asked to read from an age-appropriate children’s book, he reads it fluently and correctly. Which of the following is the most likely diagnosis in this patient?
Q72
A 26-year-old woman presents to the clinic complaining of a headache, runny nose, and malaise. A few minutes into the interview, she mentions that she recently started her job and is glad to work long hours despite the toll on her health. However, she admits that she is finding it difficult to keep up with the workload. She has numerous pending papers to correct. When advised to seek help from other teachers, she exclaims that it needs to be done in a particular way, and only she can do it the right way. This is causing her to perform poorly at work, and she is at risk of being asked to quit her very first job. Which of the following is the most likely diagnosis in this patient?
Q73
A 24-year-old woman comes to the physician because she feels sad and has had frequent, brief episodes of crying for the last month. During this period, she sleeps in every morning and spends most of her time in bed playing video games or reading. She has not been spending time with friends but still attends a weekly book club and continues to plan her annual family reunion. She stopped going to the gym, eats more, and has gained 4 kg (8.8 lb) over the past 4 weeks. Three weeks ago, she also started to smoke marijuana a few times a week. She drinks one glass of wine daily and does not smoke cigarettes. She is currently unemployed; she lost her job as a physical therapist 3 months ago. Her vital signs are within normal limits. On mental status examination, she is calm, alert, and oriented to person, place, and time. Her mood is depressed; her speech is organized, logical, and coherent. She denies suicidal thoughts. Which of the following is the most likely diagnosis?
Q74
A 77-year-old Caucasian woman presents to her primary care provider for a general checkup. The patient is with her daughter who brought her to this appointment. The patient states that she is doing well and has some minor joint pain in both hips. She states that sometimes she is sad because her husband recently died. She lives alone and follows a vegan diet. The patient's daughter states that she has noticed her mother struggling with day to day life. It started 2 years ago with her forgetting simple instructions or having difficulty running errands. Now the patient has gotten to the point where she can no longer pay her bills. Sometimes the patient forgets how to get home. The patient has a past medical history of obesity, hypertension, gastroesophageal reflux disease (GERD) controlled with pantoprazole, and diabetes mellitus. Her temperature is 99.5°F (37.5°C), blood pressure is 158/108 mmHg, pulse is 90/min, respirations are 17/min, and oxygen saturation is 98% on room air. Which of the following will most likely help with this patient's presentation?
Q75
A 4-year-old girl is brought to the pediatrician by her parents after her mother recently noticed that other girls of similar age talk much more than her daughter. Her mother reports that her language development has been abnormal and she was able to use only 5–6 words at the age of 2 years. Detailed history reveals that she has never used her index finger to indicate her interest in something. She does not enjoy going to birthday parties and does not play with other children in her neighborhood. The mother reports that her favorite “game” is to repetitively flex and extend the neck of a doll, which she always keeps with her. She is sensitive to loud sounds and starts screaming excessively when exposed to them. There is no history of delayed motor development, seizures, or any other major illness; perinatal history is normal. When she enters the doctor’s office, the doctor observes that she does not look at him. When he gently calls her by her name, she does not respond to him and continues to look at her doll. When the doctor asks her to look at a toy on his table by pointing a finger at the toy, she looks at neither his finger nor the toy. The doctor also notes that she keeps rocking her body while in the office. Which of the following is an epidemiological characteristic of the condition the girl is suffering from?
Q76
A 73-year-old woman is brought to the physician by her son because of increasing forgetfulness over the past 2 years. Initially, she used to misplace keys and forget her dog's name or her phone number. Now, she often forgets about what she has seen on television or read about the day before. She used to go for a walk every morning but stopped one month ago after she became lost on her way back home. Her son has prevented her from cooking because she has had episodes of leaving the gas stove on after making a meal. She becomes agitated when asked questions directly but is unconcerned when her son reports her history and says he is overprotective of her. She has hypertension, coronary artery disease, and hypercholesterolemia. Current medications include aspirin, enalapril, carvedilol, and atorvastatin. She is alert and oriented to place and person but not to time. Vital signs are within normal limits. Short- and long-term memory deficits are present. Her speech rhythm is normal but is frequently interrupted as she thinks of words to frame her sentences. She makes multiple errors while performing serial sevens. Her clock drawing is impaired and she draws 14 numbers. Which of the following is the most likely diagnosis?
Q77
An 84-year-old woman with Alzheimer's disease is brought to the physician by her son for a follow-up examination. The patient lives with her son, who is her primary caregiver. He reports that it is becoming gradually more difficult to care for her. She occasionally has tantrums and there are times when she does not recognize him. She sleeps 6–8 hours throughout the day and is increasingly agitated and confused at night. When the phone, television, or oven beeps she thinks she is at the dentist's office and becomes very anxious. She eats 2–3 meals a day and has a good appetite. She has not fallen. She has not left the home in weeks except for short walks. She has a history of hypertension, hyperlipidemia, atrial fibrillation, and hypothyroidism. She takes levothyroxine, aspirin, warfarin, donepezil, verapamil, lisinopril, atorvastatin, and a multivitamin daily. Her temperature is 37°C (98.4°F), pulse is 66/min, respirations are 13/min, and blood pressure is 126/82 mm Hg. Physical examination shows no abnormalities. It is important to the family that the patient continues her care in the home. Which of the following recommendations is most appropriate at this time?
Q78
A 15-year-old boy is brought to the physician by his mother because of 4 months of strange behavior. She says that during this period, he has had episodic mood swings. She has sometimes found him in his room “seemingly drunk” and with slurred speech. These episodes usually last for approximately 15 minutes, after which he becomes irritable. He has had decreased appetite, and his eyes occasionally appear red. He has trouble keeping up with his schoolwork, and his grades have worsened. Physical examination shows an eczematous rash between the upper lip and nostrils. Neurologic examination shows a delay in performing alternating palm movements. Use of which of the following is the most likely cause of this patient's condition?
Q79
A 68-year-old man seeks evaluation by a physician with complaints of worsening forgetfulness and confusion for 1 year. According to his wife, he has always been in good health and is generally very happy; however, he has started to forget important things. He recently had his driving license revoked because of multiple tickets, but he cannot recall having done anything wrong. This morning, he neglected to put on his socks and was quite agitated when she pointed this out to him. He denies having a depressed mood, sleep problems, or loss of interest. He occasionally has a glass of wine with dinner and has never smoked or used recreational drugs. His medical history and family medical history are unremarkable. His pulse is 68/min, respirations are 14/min, and blood pressure is 130/84 mm Hg. Except for a mini-mental state examination (MMSE) score of 20/30, the remainder of the physical examination is unremarkable. Imaging studies, including a chest X-ray and CT of the brain, reveal no pathologic findings. An electrocardiogram (ECG) is also normal. Laboratory testing showed the following:
Serum glucose (fasting) 76 mg/dL
Serum electrolytes:
Sodium 140 mEq/L
Potassium 4.1 mEq/L
Chloride 100 mEq/L
Serum creatinine 0.9 mg/dL
Blood urea nitrogen 11 mg/dL
Cholesterol, total: 180 mg/dL
HDL-cholesterol 45 mg/dL
LDL-cholesterol 75 mg/dL
Triglycerides 135 mg/dL
Hemoglobin (Hb%) 16 g/dL
Mean corpuscular volume (MCV) 85 fL
Reticulocyte count 0.9%
Erythrocyte count 5 million/mm³
Thyroid-stimulating hormone 3.5 µU/mL
Urinalysis
Glucose Negative
Ketones Negative
Leucocytes Negative
Nitrite Negative
RBCs Negative
Casts Negative
Which of the following is the most likely diagnosis?
Q80
An 8-year-old boy is brought to the clinic by his father for an annual well-check. His dad reports that he has been "difficult to handle" as he would not listen and follow instructions at home. "Telling him to sit still and do something is just so hard," the father says. His teacher also reports difficulties in the classroom where the child would talk out of turn and interrupt the class intermittently by doing something else. His grades have been suffering as a result. Otherwise, the patient has been healthy and up to date on his immunizations. What is the best course of management for this patient?
Mood Disorders US Medical PG Practice Questions and MCQs
Question 71: A 9-year-old boy is brought to a pediatric psychologist by his mother because of poor academic performance. The patient’s mother mentions that his academic performance was excellent in kindergarten and first grade, but his second and third-grade teachers complain that he is extremely talkative, does not complete schoolwork, and frequently makes careless mistakes. They also complain that he frequently looks at other students or outside the window during the class and is often lost during the lessons. At home, he is very talkative and disorganized. When the pediatrician asks the boy his name, he replies promptly. He was born at full term by spontaneous vaginal delivery. He is up-to-date on all vaccinations and has met all developmental milestones on time. A recent IQ test scored him at 95. His physical examination is completely normal. When he is asked to read from an age-appropriate children’s book, he reads it fluently and correctly. Which of the following is the most likely diagnosis in this patient?
A. Intellectual disability
B. Autism spectrum disorder
C. Dyslexia
D. Persistent depressive disorder
E. Attention-deficit/hyperactivity disorder (Correct Answer)
Explanation: **Attention-deficit/hyperactivity disorder**
* The child's symptoms of being **extremely talkative**, not completing schoolwork, making **careless mistakes**, and being easily distracted and disorganized are classic signs of **ADHD (Attention-deficit/hyperactivity disorder)**.
* His normal IQ, early developmental milestones, and reading fluency rule out other neurological or intellectual disabilities, while his persistent inattention and hyperactivity across settings support ADHD.
* *Intellectual disability*
* **Intellectual disability** is characterized by significant limitations in both intellectual functioning (IQ below 70) and adaptive behavior, which is contradicted by this patient's **IQ of 95** and normal developmental milestones.
* Patients with intellectual disability would typically struggle with academic performance from the start and would not have had "excellent" performance in kindergarten and first grade.
* *Autism spectrum disorder*
* **Autism spectrum disorder** involves persistent deficits in **social communication and interaction** and **restricted, repetitive patterns of behavior, interests, or activities**. This child's prompt response to his name and ability to read fluently do not align with common autistic features.
* While some social difficulties might arise from inattention, the primary symptoms do not point to core deficits in social reciprocity or communication typical of ASD.
* *Dyslexia*
* **Dyslexia** is a **specific learning disorder** primarily characterized by difficulties with **accurate and/or fluent word recognition, poor decoding, and poor spelling abilities**, despite normal intelligence.
* This patient can **read fluently and correctly from an age-appropriate children’s book**, making dyslexia an unlikely diagnosis.
* *Persistent depressive disorder*
* **Persistent depressive disorder** (dysthymia) involves a **chronically depressed mood** for at least one year in children and adolescents, often accompanied by symptoms such as low energy, poor concentration, sleep disturbance, and feelings of hopelessness.
* While poor academic performance and some difficulty concentrating could be present, the prominent symptoms of **hyperactivity** (talkativeness) and impulsivity (careless mistakes) are not typical features of depression, and a depressed mood is not reported.
Question 72: A 26-year-old woman presents to the clinic complaining of a headache, runny nose, and malaise. A few minutes into the interview, she mentions that she recently started her job and is glad to work long hours despite the toll on her health. However, she admits that she is finding it difficult to keep up with the workload. She has numerous pending papers to correct. When advised to seek help from other teachers, she exclaims that it needs to be done in a particular way, and only she can do it the right way. This is causing her to perform poorly at work, and she is at risk of being asked to quit her very first job. Which of the following is the most likely diagnosis in this patient?
A. Ego-dystonic obsessive-compulsive disorder
B. Ego-dystonic obsessive-compulsive personality disorder
C. Ego-syntonic obsessive-compulsive personality disorder (Correct Answer)
D. Ego-syntonic obsessive-compulsive disorder
E. Personality disorder not otherwise specified
Explanation: ***Ego-syntonic obsessive-compulsive personality disorder***
- Patients with **OCPD** are characterized by a pervasive pattern of **preoccupation with orderliness, perfectionism, and mental and interpersonal control**, at the expense of flexibility, openness, and efficiency. This perfectionism can lead to indecisiveness and an inability to complete tasks.
- The patient's belief that "only she can do it the right way" and her *inability to delegate tasks* despite the negative impact on her work performance are hallmarks of **ego-syntonic** traits, meaning she views her behaviors and thoughts as reasonable and appropriate. Even though these traits cause significant distress and functional impairment, she doesn't perceive them as problematic in themselves.
*Ego-dystonic obsessive-compulsive disorder*
- In **OCD**, obsessions and compulsions are typically **ego-dystonic**, meaning the individual recognizes them as irrational, intrusive, and unwanted, causing significant distress.
- The patient in the scenario does not express distress about the *nature* of her meticulous and controlling behavior, but rather about the consequences (poor performance), indicating her traits are *syntonic*.
*Ego-dystonic obsessive-compulsive personality disorder*
- This term is a contradiction in terms; **personality disorders** are, by definition, generally **ego-syntonic**. If obsessive-compulsive symptoms were ego-dystonic, it would point towards OCD.
- The core diagnostic feature of a personality disorder is that the problematic patterns are congruent with the individual's self-image and experienced as characteristic parts of themselves.
*Ego-syntonic obsessive-compulsive disorder*
- **OCD** is characterized by *recurrent, persistent thoughts, urges, or images (obsessions)* and *repetitive behaviors or mental acts (compulsions)* that are typically **ego-dystonic** (i.e., not aligned with one's self-perception and often distressing).
- The patient's description focuses on a *pervasive personality style* rather than specific discrete obsessions or compulsions that she would find distressing or irrational.
*Personality disorder not otherwise specified*
- While this category exists for cases that don't meet full criteria for a specific personality disorder, the patient's symptoms **clearly align with the diagnostic criteria for Obsessive-Compulsive Personality Disorder**.
- There is enough specific information provided to make a more precise diagnosis, rendering "not otherwise specified" less appropriate here.
Question 73: A 24-year-old woman comes to the physician because she feels sad and has had frequent, brief episodes of crying for the last month. During this period, she sleeps in every morning and spends most of her time in bed playing video games or reading. She has not been spending time with friends but still attends a weekly book club and continues to plan her annual family reunion. She stopped going to the gym, eats more, and has gained 4 kg (8.8 lb) over the past 4 weeks. Three weeks ago, she also started to smoke marijuana a few times a week. She drinks one glass of wine daily and does not smoke cigarettes. She is currently unemployed; she lost her job as a physical therapist 3 months ago. Her vital signs are within normal limits. On mental status examination, she is calm, alert, and oriented to person, place, and time. Her mood is depressed; her speech is organized, logical, and coherent. She denies suicidal thoughts. Which of the following is the most likely diagnosis?
A. Bipolar disorder
B. Substance use disorder
C. Major depressive disorder
D. Adjustment disorder (Correct Answer)
E. Persistent Depressive Disorder (Dysthymia)
Explanation: ***Adjustment disorder***
- This diagnosis is characterized by the development of emotional or behavioral symptoms in response to an identifiable stressor (such as losing a job) occurring within **3 months** of the onset of the stressor.
- The patient exhibits depressive symptoms (sadness, crying, increased sleep, anhedonia, weight gain) that do not meet the full criteria for a major depressive episode and do not significantly impair social/occupational functioning, as evidenced by her continued participation in a book club and planning her family reunion.
*Bipolar disorder*
- This disorder typically involves episodes of **mania or hypomania** along with depressive episodes, neither of which are described in the patient's presentation.
- Her symptoms are consistently depressive in nature and linked to a specific stressor, without periods of elevated mood, increased energy, or decreased need for sleep.
*Substance use disorder*
- While the patient has recently started smoking marijuana and drinks alcohol, these behaviors developed *after* the onset of her depressive symptoms and a known stressor.
- Her marijuana use is still relatively recent ("a few times a week") and not yet described as causing significant impairment or dependence that would typically define a substance use disorder as the primary diagnosis.
*Major depressive disorder*
- This diagnosis requires a severe and pervasive depressive episode that lasts for at least **2 weeks** and significantly impairs functioning in multiple areas of life.
- Although she has several depressive symptoms, her continued ability to engage in some social activities (book club) and plan events (family reunion) suggests that the impairment is not as severe or pervasive as typically seen in MDD. Additionally, her symptoms are clearly linked to a recent life stressor, which points away from MDD as the primary diagnosis.
*Persistent Depressive Disorder (Dysthymia)*
- This disorder is characterized by a chronically depressed mood that lasts for at least **2 years** (or 1 year in children/adolescents), with symptoms that are generally milder than major depression but more persistent.
- The patient's symptoms have only been present for one month, which is far too short a duration to meet the diagnostic criteria for persistent depressive disorder.
Question 74: A 77-year-old Caucasian woman presents to her primary care provider for a general checkup. The patient is with her daughter who brought her to this appointment. The patient states that she is doing well and has some minor joint pain in both hips. She states that sometimes she is sad because her husband recently died. She lives alone and follows a vegan diet. The patient's daughter states that she has noticed her mother struggling with day to day life. It started 2 years ago with her forgetting simple instructions or having difficulty running errands. Now the patient has gotten to the point where she can no longer pay her bills. Sometimes the patient forgets how to get home. The patient has a past medical history of obesity, hypertension, gastroesophageal reflux disease (GERD) controlled with pantoprazole, and diabetes mellitus. Her temperature is 99.5°F (37.5°C), blood pressure is 158/108 mmHg, pulse is 90/min, respirations are 17/min, and oxygen saturation is 98% on room air. Which of the following will most likely help with this patient's presentation?
A. Vitamin B12 and discontinue pantoprazole
B. No intervention needed
C. Donepezil (Correct Answer)
D. Fluoxetine and cognitive behavioral therapy
E. Lisinopril and metoprolol
Explanation: ***Correct: Donepezil***
- This patient presents with **progressive dementia**, most consistent with **Alzheimer's disease**: gradual cognitive decline over 2 years, short-term memory loss (forgetting instructions), executive dysfunction (unable to pay bills), impaired navigation (getting lost), and functional decline in activities of daily living (ADLs).
- **Donepezil**, an **acetylcholinesterase inhibitor**, is first-line pharmacotherapy for mild-to-moderate Alzheimer's disease, improving cognitive function by increasing acetylcholine availability in the brain.
- Key differentiator: The **progressive, global cognitive impairment** with functional decline over years distinguishes this from reversible causes or mood disorders.
*Incorrect: Vitamin B12 and discontinue pantoprazole*
- While **vitamin B12 deficiency** can cause cognitive impairment and this patient has risk factors (vegan diet, chronic PPI use with pantoprazole), the **severity, duration, and progressive nature** of her symptoms indicate a **neurodegenerative process** rather than a reversible nutritional deficiency.
- B12 deficiency typically presents with more prominent neurological signs (peripheral neuropathy, subacute combined degeneration) and would be expected to show improvement with supplementation.
- Though checking B12 levels would be part of the dementia workup, it would not be the **primary treatment** for this presentation.
*Incorrect: No intervention needed*
- This patient has **significant functional impairment** with safety concerns (getting lost, inability to manage finances), requiring immediate intervention.
- Progressive cognitive decline causing loss of independence in ADLs is never "normal aging" and always warrants medical evaluation and treatment.
- Failure to intervene risks patient safety and further deterioration.
*Incorrect: Fluoxetine and cognitive behavioral therapy*
- While the patient reports sadness related to her husband's death (suggesting **grief** or possible **depression**), her **predominant symptoms are cognitive and functional**, not primarily mood-related.
- **Key differentiation**: Depression can cause "pseudodementia" with cognitive complaints, but true dementia shows objective functional decline (inability to pay bills, getting lost) that progresses regardless of mood, whereas depression-related cognitive symptoms typically improve with mood treatment.
- The **2-year progressive course** with worsening executive function points to **organic dementia**, not a primary mood disorder.
- Fluoxetine and CBT target depression but would not address the underlying neurodegenerative process.
*Incorrect: Lisinopril and metoprolol*
- The patient's blood pressure is elevated (158/108 mmHg), indicating uncontrolled **hypertension** that should be managed.
- While controlling vascular risk factors is important in dementia management (to prevent vascular dementia progression), treating hypertension would not address her **current cognitive symptoms** or provide symptomatic relief.
- The **primary issue** is dementia requiring acetylcholinesterase inhibitor therapy; blood pressure management is secondary.
Question 75: A 4-year-old girl is brought to the pediatrician by her parents after her mother recently noticed that other girls of similar age talk much more than her daughter. Her mother reports that her language development has been abnormal and she was able to use only 5–6 words at the age of 2 years. Detailed history reveals that she has never used her index finger to indicate her interest in something. She does not enjoy going to birthday parties and does not play with other children in her neighborhood. The mother reports that her favorite “game” is to repetitively flex and extend the neck of a doll, which she always keeps with her. She is sensitive to loud sounds and starts screaming excessively when exposed to them. There is no history of delayed motor development, seizures, or any other major illness; perinatal history is normal. When she enters the doctor’s office, the doctor observes that she does not look at him. When he gently calls her by her name, she does not respond to him and continues to look at her doll. When the doctor asks her to look at a toy on his table by pointing a finger at the toy, she looks at neither his finger nor the toy. The doctor also notes that she keeps rocking her body while in the office. Which of the following is an epidemiological characteristic of the condition the girl is suffering from?
A. There has been a steady decline in prevalence in the United States over the last decade.
B. There is an increased risk if the mother smoked during pregnancy.
C. There is an increased risk with low prenatal maternal serum vitamin D level.
D. There is an increased incidence if the mother gives birth before 25 years of age.
E. This condition is 4 times more common in boys than girls. (Correct Answer)
Explanation: **_This condition is 4 times more common in boys than girls._**
- The clinical presentation, including **impaired social interaction** (not looking at the doctor, not responding to her name, not playing with other children, not enjoying parties), **communication deficits** (delayed language, lack of pointing), **repetitive behaviors** (flexing doll's neck, body rocking) and **sensory sensitivities** (screaming at loud sounds), is highly suggestive of **Autism Spectrum Disorder (ASD)**.
- **ASD** is indeed diagnosed approximately four times more often in boys than in girls, making this a characteristic epidemiological feature.
*There has been a steady decline in prevalence in the United States over the last decade.*
- The **prevalence of ASD** has actually been **steadily increasing** in the United States and globally over the last few decades, partly due to increased awareness, improved diagnostic criteria, and better screening.
- This statement is contrary to current epidemiological trends for **ASD**.
*There is an increased risk if the mother smoked during pregnancy.*
- While maternal smoking during pregnancy is linked to other developmental issues like **ADHD** and **premature birth**, a definitive, strong, and consistent causal link to a significantly increased risk of **ASD** has not been established.
- Research on environmental risk factors for **ASD** is ongoing, but maternal smoking is not a primary, well-established epidemiological characteristic.
*There is an increased risk with low prenatal maternal serum vitamin D level.*
- Some studies suggest a potential association between low prenatal maternal vitamin D levels and an increased risk of **ASD**, but this link is **not yet definitively established** and requires further research to confirm causation.
- It is considered a potential risk factor, but not a widely accepted or strong epidemiological characteristic for the condition.
*There is an increased incidence if the mother gives birth before 25 years of age.*
- The risk of **ASD** has been more consistently associated with **advanced parental age** (both maternal and paternal), not with younger maternal age.
- Studies generally indicate a **higher risk for children born to older parents**, making this statement inaccurate.
Question 76: A 73-year-old woman is brought to the physician by her son because of increasing forgetfulness over the past 2 years. Initially, she used to misplace keys and forget her dog's name or her phone number. Now, she often forgets about what she has seen on television or read about the day before. She used to go for a walk every morning but stopped one month ago after she became lost on her way back home. Her son has prevented her from cooking because she has had episodes of leaving the gas stove on after making a meal. She becomes agitated when asked questions directly but is unconcerned when her son reports her history and says he is overprotective of her. She has hypertension, coronary artery disease, and hypercholesterolemia. Current medications include aspirin, enalapril, carvedilol, and atorvastatin. She is alert and oriented to place and person but not to time. Vital signs are within normal limits. Short- and long-term memory deficits are present. Her speech rhythm is normal but is frequently interrupted as she thinks of words to frame her sentences. She makes multiple errors while performing serial sevens. Her clock drawing is impaired and she draws 14 numbers. Which of the following is the most likely diagnosis?
A. Lewy-body dementia
B. Alzheimer disease (Correct Answer)
C. Frontotemporal dementia
D. Normal pressure hydrocephalus
E. Creutzfeldt-Jakob disease
Explanation: **Alzheimer disease**
- The patient's presentation with **progressive memory impairment** (misplacing keys, forgetting recent events), **executive dysfunction** (getting lost, leaving stove on, impaired clock drawing), and **language difficulties** (word-finding pauses) over 2 years is highly characteristic of Alzheimer disease.
- The **insidious onset** and gradual cognitive decline affecting multiple domains, along with relative preservation of motor function initially, are key diagnostic features.
*Lewy-body dementia*
- This condition is often characterized by **fluctuating cognition**, **visual hallucinations**, and **parkinsonism**, none of which are prominent in this patient's presentation.
- While memory impairment can occur, the core features of Lewy body dementia are not described here.
*Frontotemporal dementia*
- **Early behavioral changes** (e.g., disinhibition, apathy) or **prominent language deficits** (e.g., aphasia without initial memory problems) are common in frontotemporal dementia.
- This patient's primary complaint is memory loss, and behavioral changes are reactive rather than disinhibited, making frontotemporal dementia less likely.
*Normal pressure hydrocephalus*
- The classic triad for normal pressure hydrocephalus includes **gait disturbance**, **urinary incontinence**, and **dementia**.
- While dementia is present, there is no mention of gait abnormalities or urinary issues in this patient.
*Creutzfeldt-Jakob disease*
- This is a rapidly progressive and fatal neurodegenerative disorder with a typical course of **weeks to months**, not 2 years.
- It usually presents with **myoclonus**, **ataxia**, and **rapidly progressive dementia**, which are not seen in this case.
Question 77: An 84-year-old woman with Alzheimer's disease is brought to the physician by her son for a follow-up examination. The patient lives with her son, who is her primary caregiver. He reports that it is becoming gradually more difficult to care for her. She occasionally has tantrums and there are times when she does not recognize him. She sleeps 6–8 hours throughout the day and is increasingly agitated and confused at night. When the phone, television, or oven beeps she thinks she is at the dentist's office and becomes very anxious. She eats 2–3 meals a day and has a good appetite. She has not fallen. She has not left the home in weeks except for short walks. She has a history of hypertension, hyperlipidemia, atrial fibrillation, and hypothyroidism. She takes levothyroxine, aspirin, warfarin, donepezil, verapamil, lisinopril, atorvastatin, and a multivitamin daily. Her temperature is 37°C (98.4°F), pulse is 66/min, respirations are 13/min, and blood pressure is 126/82 mm Hg. Physical examination shows no abnormalities. It is important to the family that the patient continues her care in the home. Which of the following recommendations is most appropriate at this time?
A. Start quetiapine daily
B. Start lorazepam as needed
C. Frequently play classical music
D. Adhere to a regular sleep schedule (Correct Answer)
E. Schedule frequent travel
Explanation: ***Adhere to a regular sleep schedule***
- The patient exhibits **sundowning**, characterized by increased confusion and agitation in the evening, along with fragmented sleep patterns (sleeping 6-8 hours during the day). Establishing a **regular sleep-wake cycle** can significantly alleviate these symptoms.
- This is a **non-pharmacological intervention** that respects the family's desire for continued home care and addresses a key behavioral disturbance in Alzheimer's patients.
*Start quetiapine daily*
- **Antipsychotics** like quetiapine should be used with extreme caution in elderly patients with dementia due to increased risk of **mortality**, cardiovascular events, and stroke.
- They are typically reserved for severe, intractable agitation or psychosis after non-pharmacological methods have failed.
*Start lorazepam as needed*
- **Benzodiazepines** like lorazepam can worsen cognitive impairment, increase the risk of falls, and cause paradoxical agitation in elderly patients with dementia.
- Their use should be limited, especially given the patient's existing confusion and agitation.
*Frequently play classical music*
- While music therapy can be beneficial for mood and anxiety in some dementia patients, it's a **complementary therapy** that may not directly address the primary issue of **sundowning and sleep disturbance** as effectively as a strict sleep schedule.
- There is no indication that music directly addresses the root cause of her specific agitation related to misinterpreting sounds.
*Schedule frequent travel*
- **Frequent travel** would likely cause increased disorientation, anxiety, and agitation in a patient with Alzheimer's disease, especially given her current confusion and misinterpretation of everyday sounds.
- Maintaining a **familiar and stable environment** is crucial for individuals with dementia.
Question 78: A 15-year-old boy is brought to the physician by his mother because of 4 months of strange behavior. She says that during this period, he has had episodic mood swings. She has sometimes found him in his room “seemingly drunk” and with slurred speech. These episodes usually last for approximately 15 minutes, after which he becomes irritable. He has had decreased appetite, and his eyes occasionally appear red. He has trouble keeping up with his schoolwork, and his grades have worsened. Physical examination shows an eczematous rash between the upper lip and nostrils. Neurologic examination shows a delay in performing alternating palm movements. Use of which of the following is the most likely cause of this patient's condition?
A. Inhalants (Correct Answer)
B. Phencyclidine
C. Alcohol
D. Cocaine
E. Marijuana
Explanation: ***Inhalants***
- The patient's presentation with acute, transient episodes of altered mental status ("seemingly drunk," slurred speech, irritability), decreased appetite, red eyes, and declining school performance are classic signs of inhalant abuse. The **eczematous rash between the upper lip and nostrils** (a condition known as **"huffer's rash"** or **"glue sniffer's rash"**) is a highly specific dermatological sign of chronic inhalant use.
- Neurological signs such as difficulty with **alternating palm movements** (dysdiadochokinesia) indicate cerebellar dysfunction, which can be a consequence of inhalant neurotoxicity, particularly from toluene and other solvents.
*Phencyclidine*
- While phencyclidine (PCP) can cause acute behavioral changes, aggression, and psychotic symptoms, it typically results in a more profound and prolonged dissociative state, often with **nystagmus**, rather than brief, "drunk-like" episodes.
- PCP intoxication does not typically cause a specific perioral rash or red eyes in the same manner as inhalants.
*Alcohol*
- Although the patient's "drunk-like" appearance and slurred speech are consistent with alcohol intoxication, the very brief 15-minute duration of these episodes is highly unusual for significant alcohol consumption.
- Alcohol intoxication does not cause a specific eczematous rash between the upper lip and nostrils.
*Cocaine*
- Cocaine use typically manifests as stimulant effects like **euphoria**, increased energy, dilated pupils, and tachycardia, followed by a "crash" with depression or irritability.
- It does not present with "drunk-like" behavior, slurred speech, or the characteristic perioral rash described.
*Marijuana*
- Marijuana use can cause red eyes and decreased motivation (leading to declining school performance), but the "seemingly drunk" appearance, slurred speech, and acute irritable mood swings are less characteristic.
- Marijuana does not cause a specific perioral eczematous rash or cerebellar signs like dysdiadochokinesia.
Question 79: A 68-year-old man seeks evaluation by a physician with complaints of worsening forgetfulness and confusion for 1 year. According to his wife, he has always been in good health and is generally very happy; however, he has started to forget important things. He recently had his driving license revoked because of multiple tickets, but he cannot recall having done anything wrong. This morning, he neglected to put on his socks and was quite agitated when she pointed this out to him. He denies having a depressed mood, sleep problems, or loss of interest. He occasionally has a glass of wine with dinner and has never smoked or used recreational drugs. His medical history and family medical history are unremarkable. His pulse is 68/min, respirations are 14/min, and blood pressure is 130/84 mm Hg. Except for a mini-mental state examination (MMSE) score of 20/30, the remainder of the physical examination is unremarkable. Imaging studies, including a chest X-ray and CT of the brain, reveal no pathologic findings. An electrocardiogram (ECG) is also normal. Laboratory testing showed the following:
Serum glucose (fasting) 76 mg/dL
Serum electrolytes:
Sodium 140 mEq/L
Potassium 4.1 mEq/L
Chloride 100 mEq/L
Serum creatinine 0.9 mg/dL
Blood urea nitrogen 11 mg/dL
Cholesterol, total: 180 mg/dL
HDL-cholesterol 45 mg/dL
LDL-cholesterol 75 mg/dL
Triglycerides 135 mg/dL
Hemoglobin (Hb%) 16 g/dL
Mean corpuscular volume (MCV) 85 fL
Reticulocyte count 0.9%
Erythrocyte count 5 million/mm³
Thyroid-stimulating hormone 3.5 µU/mL
Urinalysis
Glucose Negative
Ketones Negative
Leucocytes Negative
Nitrite Negative
RBCs Negative
Casts Negative
Which of the following is the most likely diagnosis?
A. Alzheimer’s dementia (Correct Answer)
B. Creutzfeldt-Jakob disease
C. Lewy body dementia
D. Parkinson’s disease
E. Vascular dementia
Explanation: ***Alzheimer’s dementia***
- The patient presents with **progressive memory loss** and **confusion** that has worsened over a year, along with **agitational behavior** and difficulty with daily tasks (neglecting to put on socks), which are classic symptoms of Alzheimer's dementia.
- The **MMSE score of 20/30** indicates cognitive impairment, and the absence of other neurological findings or clear vascular risk factors supports this diagnosis.
*Creutzfeldt-Jakob disease*
- This is a rare, rapidly progressive, and fatal neurodegenerative disease that typically presents with **rapidly progressive dementia**, **myoclonus**, and other neurological signs, which are not described in this case.
- The patient's symptoms have progressed over a year, which is not as rapid as the typical course of CJD.
*Lewy body dementia*
- Characterized by **fluctuating cognition**, **recurrent visual hallucinations**, and **spontaneous parkinsonism**, which are not reported in this patient.
- While agitation can occur, the core features of Lewy body dementia are absent.
*Parkinson’s disease*
- Primarily a **movement disorder** characterized by **bradykinesia**, **rigidity**, **tremor**, and **postural instability**. While dementia can occur in later stages (Parkinson's disease dementia), the initial presentation in this patient is predominantly cognitive decline without prominent motor symptoms.
- The patient's physical examination is "unremarkable," suggesting an absence of parkinsonian motor signs.
*Vascular dementia*
- Typically associated with a history of **stroke** or significant **vascular risk factors** (e.g., uncontrolled hypertension, diabetes) and often presents with a **step-wise decline** in cognitive function.
- This patient has a largely unremarkable medical history, controlled blood pressure, and normal cholesterol, and a CT scan showed no pathological findings (e.g., infarcts), making vascular dementia less likely.
Question 80: An 8-year-old boy is brought to the clinic by his father for an annual well-check. His dad reports that he has been "difficult to handle" as he would not listen and follow instructions at home. "Telling him to sit still and do something is just so hard," the father says. His teacher also reports difficulties in the classroom where the child would talk out of turn and interrupt the class intermittently by doing something else. His grades have been suffering as a result. Otherwise, the patient has been healthy and up to date on his immunizations. What is the best course of management for this patient?
A. Haloperidol
B. Methylphenidate (Correct Answer)
C. Reassurance
D. Family therapy
E. Psychodynamic therapy
Explanation: ***Methylphenidate***
- The patient's symptoms are highly suggestive of **Attention-Deficit/Hyperactivity Disorder (ADHD)**, including **inattention** (difficulty following instructions), **hyperactivity** (cannot sit still), and **impulsivity** (talking out of turn, interrupting).
- According to **AAP Clinical Practice Guidelines**, school-age children (6-11 years) with ADHD should be treated with **FDA-approved ADHD medication** (stimulants like methylphenidate or amphetamines) **AND/OR behavioral therapy**.
- **Methylphenidate** (e.g., Ritalin, Concerta) is a first-line stimulant medication that effectively reduces core ADHD symptoms and is appropriate for this 8-year-old with significant functional impairment affecting **academic performance** and **home/school behavior**.
- While behavioral interventions are also important, the question asks for the "best course of management," and pharmacotherapy is an evidence-based first-line treatment for school-age children with clear ADHD symptomatology.
*Family therapy*
- While **behavioral interventions** and **parent training** are important components of ADHD management and can be used alone or in combination with medication, **family therapy** specifically is not the primary evidence-based intervention for ADHD.
- Behavioral parent training programs that teach specific strategies for managing ADHD behaviors are more targeted than general family therapy.
- For school-age children with significant impairment, medication is typically indicated and should not necessarily be delayed pending completion of family therapy alone.
*Haloperidol*
- **Haloperidol** is an antipsychotic medication primarily used to treat psychotic disorders (e.g., schizophrenia) or severe tics in Tourette's syndrome.
- It is **not indicated** for ADHD symptoms and carries significant risks of **extrapyramidal side effects** (dystonia, akathisia, tardive dyskinesia), making it inappropriate for this presentation.
*Reassurance*
- Simply offering **reassurance** is insufficient for a child with significant behavioral difficulties causing **academic decline** and impairment in multiple settings (home and school).
- The symptoms meet criteria for likely **ADHD**, which requires active intervention, not just reassurance.
*Psychodynamic therapy*
- **Psychodynamic therapy** explores unconscious processes and past experiences, which is **not an evidence-based treatment** for ADHD.
- It may be useful for certain emotional or personality issues but does not address the core neurobiological deficits underlying ADHD symptoms like inattention, hyperactivity, and impulsivity.