A 24-year-old woman presents with her husband to a physician with the complaints of fever, cough, and cold for the past 5 days. When the physician asks her if she has taken any medication for her symptoms, she answers, “My husband and I possess great powers to heal sickness. So I tried to cure my symptoms with my power. However, due to some divine cause, it did not work this time, so I thought I should seek medical advice”. Upon asking her husband about this, he says, "I have always had an immense ability to heal others through my powerful thoughts. It is only after I married her that she came to realize the powers within herself.” The physician examines her and prescribes appropriate medications for her symptoms. A year later, the woman presents again to the same physician with a cough and cold for 2 days. The physician asks her why did she not use her ‘power’ this time. She replies, “I separated from my husband 6 months ago, and I no longer believe that I nor my husband had any special power.” The woman denies any hallucinations, mood disturbances, and socio-occupational impairment to date. Which of the following conditions was this patient most likely suffering from?
Q2
A 44-year-old man is brought to the clinic by his wife insisting that her husband has been acting strange lately. He is a dentist by profession and has no known medical conditions. For the past 6 weeks, he has insisted on listening to the 6 PM news on the radio. He is adamant that the news anchor is referencing his life during the broadcasts. Apart from this, his wife states that her husband is fine. He and his wife deny the use of any prescribed medications or illicit drugs. He is a non-smoker and drinks alcohol only on social occasions. Physical examination and routine laboratory investigations are normal. What is the most likely diagnosis?
Q3
A 45-year-old man visits a psychiatrist with his wife asking for help with their ongoing family problem. The couple has been married for 20 years and the last 2 months the patient is fully convinced that his wife is cheating on him. He has hired numerous private investigators, who deny any such evidence for an extramarital affair. This persistent belief has begun to stress both sides of the family. The spouse has never in the past nor currently shown any evidence of infidelity. He is still able to hold a steady job and provide for his 2 children. Which of the following statements below is a diagnostic criterion for the above condition?
Q4
Two dizygotic twins present to the university clinic because they believe they are being poisoned through the school's cafeteria food. They have brought these concerns up in the past, but no other students or cafeteria staff support this belief. Both of them are average students with strong and weak subject areas as demonstrated by their course grade-books. They have no known medical conditions and are not known to abuse illicit substances. Which statement best describes the condition these patients have?
Q5
A 21-year-old woman is brought by her mother to a psychiatrist due to concerns about her behavior. The patient’s mother tells the psychiatrist that she believes that a famous Hollywood celebrity actor loves her and will marry her. When the patient is asked about this, she says that she attended a function at which this actor was the guest of honor six months back, and he waved his hand at her by which she understood that he loves her. However, when she tries to contact him over the phone, he does not respond, which she says is probably because he is too busy with his career at present. When asked why the successful actor would marry her, she says, “Celebrities often prefer to marry ordinary people and that is why he expressed his interest in me that day”. The patient is otherwise healthy with no known medical condition. She denies any mood disturbances, hallucinations, or anxiety. She is currently working as an assistant manager at a private advertising firm and has a normal socio-occupational life. Which of the following is the most likely diagnosis in this patient?
Q6
A 27-year-old man presents to his primary care physician for exposure to toxic materials. The patient states that when he left for work this morning he was certain that he had closed the door to his pantry. However, upon returning home, he saw that the door to his pantry was wide open. The patient is certain that his neighbors have been tampering with his food and potentially poisoned him. He further states that he has known, ever since they have moved in, that they have been trying to break into his house and steal his things. He has tried multiple times to get them evicted from the building to no avail. It is for this reason that he is certain that they are trying to get their revenge upon him. The physician performs a physical exam and tells the patient that he thinks there is nothing to be concerned about, but that he should call him or come into the office if he experiences any symptoms. The patient is outraged at this news and requests a competent doctor who is not colluding with his enemies. He storms out of the office angrily, stating that he deserves the best in medical care, not this. Which of the following is the most likely personality disorder that this patient is suffering from?
Q7
A 53-year-old man is brought into the emergency department by ambulance. He was found stumbling in the street. He smells of alcohol and has difficulty answering any questions or giving any history about recent events. He is diagnosed with acute ethanol intoxication. After a night of IV fluid and sleep, he recovers and becomes talkative. He describes an outlandish personal history as a war hero, a movie star, and a famous professor. On physical examination, the patient is malnourished, thin, disheveled, and mildly agitated. He has temporal wasting and conjunctival pallor. Which of the following symptoms would not improve with aggressive therapy including thiamine in this patient?
Q8
A 21-year-old college student comes to the physician because of left knee pain. The pain started when he fell off his bike one year ago; since then he has had intermittent stabbing pain and tingling in his knee. The patient says that the pain is caused by a device that was implanted by the US government to control his thoughts and actions. Every time he does something they do not want him to do, the device will send an electromagnetic impulse to his knee. He maintains the device was also responsible for the bicycle accident. Over the past 6 months, it has caused him to hear voices telling him to harm himself or others; he does not listen to these commands because he does not want to “play by their rules.” He has avoided meeting his family and friends since the voices started. He drinks 2 beers a day but does not use illicit drugs. Vital signs are within normal limits. The left knee is nontender and nonerythematous with no swelling. Range of motion is normal. Neurologic examination shows no abnormalities. On mental status examination, the patient appears expressionless. Which of the following is the most appropriate long-term treatment?
Q9
A 35-year-old woman is brought to the inpatient psychiatric unit by the police after she was found violating the conditions of her restraining order by parking on the side street of her "lover’s" home every night for the past week. Her "lover", a famous hometown celebrity, has adamantly denied any relationship with the patient over the past 6 months. The patient insists that ever since he signed a copy of his album at a local signing, she knew they were in love. Despite him having his own wife and children, the patient insists that he is in love with her and goes to his house to meet in secret. Physical examination of the patient is unremarkable. Urine toxicology is negative. Which of the following statements best describes this patient’s condition?
Q10
A 46-year-old woman presents to a psychiatrist for evaluation. Three months prior, the patient moved to a new apartment building, and since then, she has become increasingly convinced that her doorman has been stealing her packages and going into her apartment while she is not home. She states that objects do not stay where she leaves them, and sometimes she expects mail but never receives it. She has filed numerous complaints with her leasing company. The building has 24-hour security footage, however, which has never shown any other person entering her apartment. On further questioning, the patient denies audiovisual hallucinations or changes in sleep, mood, energy levels, or eating. The family reports that her behavior and affect have not changed. The patient works as a pharmacist. She has no psychiatric history, although her father had a history of major depressive disorder. Which of the following is the likely diagnosis?
Delusional disorder US Medical PG Practice Questions and MCQs
Question 1: A 24-year-old woman presents with her husband to a physician with the complaints of fever, cough, and cold for the past 5 days. When the physician asks her if she has taken any medication for her symptoms, she answers, “My husband and I possess great powers to heal sickness. So I tried to cure my symptoms with my power. However, due to some divine cause, it did not work this time, so I thought I should seek medical advice”. Upon asking her husband about this, he says, "I have always had an immense ability to heal others through my powerful thoughts. It is only after I married her that she came to realize the powers within herself.” The physician examines her and prescribes appropriate medications for her symptoms. A year later, the woman presents again to the same physician with a cough and cold for 2 days. The physician asks her why did she not use her ‘power’ this time. She replies, “I separated from my husband 6 months ago, and I no longer believe that I nor my husband had any special power.” The woman denies any hallucinations, mood disturbances, and socio-occupational impairment to date. Which of the following conditions was this patient most likely suffering from?
A. Brief psychotic disorder
B. Folie à deux (Correct Answer)
C. Culture-specific psychosis
D. Residual phase of schizophrenia
E. Schizophreniform disorder
Explanation: ***Folie à deux***
- This condition is characterized by a **shared delusional belief** between two or more people who are in a close relationship. One person, typically the dominant partner, has a primary psychotic disorder with delusions, and the other person adopts these delusions.
- In this case, the husband likely initiated the delusional belief about healing powers, which his wife subsequently adopted. Her belief resolved when she separated from him, indicating the **dependent nature** of her delusion.
*Brief psychotic disorder*
- This disorder involves a sudden onset of psychotic symptoms (delusions, hallucinations, disorganized speech or behavior) lasting more than one day but less than one month, with eventual full return to premorbid functioning.
- While the patient exhibited a delusional belief, the **shared nature** with her husband and the **resolution upon separation** are more characteristic of folie à deux than an independent brief psychotic episode.
*Culture-specific psychosis*
- This refers to psychotic symptoms and syndromes that are recognized within a particular culture and associated with specific cultural explanations.
- Although some cultures may have beliefs in spiritual healing, the specific scenario of a **delusional belief shared between two individuals** in a close relationship points more directly to folie à deux rather than a broad culture-specific psychosis.
*Residual phase of schizophrenia*
- This phase occurs after an acute episode of schizophrenia, where prominent positive symptoms (delusions, hallucinations) have subsided, but milder negative symptoms (e.g., social withdrawal, blunted affect) or attenuated positive symptoms persist.
- The patient explicitly **denies hallucinations, mood disturbances, and socio-occupational impairment**, and her delusional belief was directly linked to her husband, which does not fit the diagnostic criteria for a residual phase of schizophrenia.
*Schizophreniform disorder*
- This disorder is characterized by symptoms similar to schizophrenia (delusions, hallucinations, disorganized speech, negative symptoms) but lasts for more than one month and less than six months.
- The patient's presentation does not describe the broad range of symptoms or the duration required for a schizophreniform disorder, and the **resolving nature of her delusion upon separation** is a key differentiating factor.
Question 2: A 44-year-old man is brought to the clinic by his wife insisting that her husband has been acting strange lately. He is a dentist by profession and has no known medical conditions. For the past 6 weeks, he has insisted on listening to the 6 PM news on the radio. He is adamant that the news anchor is referencing his life during the broadcasts. Apart from this, his wife states that her husband is fine. He and his wife deny the use of any prescribed medications or illicit drugs. He is a non-smoker and drinks alcohol only on social occasions. Physical examination and routine laboratory investigations are normal. What is the most likely diagnosis?
A. Persecutory delusions
B. Delusion of control
C. Erotomanic delusions
D. Delusion of reference (Correct Answer)
E. Grandiose delusions
Explanation: ***Delusion of reference***
- This is characterized by the belief that **events, objects, or people in the environment** have a particular and unusual significance, often of a negative or threatening nature, specifically directed at oneself.
- The man's belief that the **news anchor is referencing his life** during broadcasts, despite no actual connection, is a classic presentation of a delusion of reference.
*Persecutory delusions*
- **Persecutory delusions** involve the belief that one is being tormented, followed, tricked, spied on, or ridiculed.
- While the delusion involves external references, it does not explicitly state that the news anchor is actively *harming* or *conspiring against* him, making it less specific than a delusion of reference, which describes the belief that common occurrences refer to oneself.
*Delusion of control*
- This delusion involves the belief that **one's thoughts, feelings, impulses, or actions are not one's own** but are being imposed or controlled by some external force.
- The patient's symptom is about external events referring to him, not about his internal experiences being controlled by an external force.
*Erotomanic delusions*
- This involves the belief that **another person, usually of higher status, is in love with the individual**.
- There is no indication in the scenario that the man believes the news anchor is in love with him.
*Grandiose delusions*
- This is characterized by beliefs of **inflated worth, power, knowledge, identity, or a special relationship to a deity or famous person**.
- The patient's delusion does not involve exaggerated self-importance or a belief in special abilities, but rather a misinterpretation of external communications.
Question 3: A 45-year-old man visits a psychiatrist with his wife asking for help with their ongoing family problem. The couple has been married for 20 years and the last 2 months the patient is fully convinced that his wife is cheating on him. He has hired numerous private investigators, who deny any such evidence for an extramarital affair. This persistent belief has begun to stress both sides of the family. The spouse has never in the past nor currently shown any evidence of infidelity. He is still able to hold a steady job and provide for his 2 children. Which of the following statements below is a diagnostic criterion for the above condition?
A. Delusions are better explained by another DSM-5 diagnosis
B. Must have prominent hallucinations in addition to delusions
C. Daily functioning must be impaired
D. Must have active symptoms for 1 month followed by 6 months total duration
E. Delusions must be non-bizarre (Correct Answer)
Explanation: ***Delusions must be non-bizarre***
- This is a key diagnostic criterion for **delusional disorder**, where the delusions are plausible and involve situations that could conceivably happen, even if they aren't true (e.g., being cheated on, followed, or having a disease).
- The patient's belief that his wife is cheating on him, despite evidence to the contrary, is a **plausible but false belief**, fitting the definition of a non-bizarre delusion.
*Delusions are better explained by another DSM-5 diagnosis*
- This is an **exclusion criterion**; if delusions are better accounted for by another disorder (e.g., schizophrenia, mood disorder with psychotic features, substance-induced psychosis), then delusional disorder is not diagnosed.
- The patient's presentation does not suggest other DSM-5 diagnoses that would better explain the delusions.
*Must have prominent hallucinations in addition to delusions*
- **Prominent hallucinations** are usually associated with disorders like **schizophrenia** or **schizoaffective disorder**.
- In **delusional disorder**, hallucinations, if present, are not prominent and are typically related to the delusional theme.
*Daily functioning must be impaired*
- A distinguishing characteristic of delusional disorder is that **daily functioning is typically not markedly impaired**, and behavior is not obviously bizarre, apart from the direct impact of the delusion.
- The patient in the vignette is able to hold a steady job and care for his children, which supports this point.
*Must have active symptoms for 1 month followed by 6 months total duration*
- This criterion (1 month active symptoms, 6 months total duration) is specific to the diagnosis of **schizophrenia**, not delusional disorder.
- For delusional disorder, the duration of delusions is **1 month or longer**, without necessarily requiring a specific active phase or total duration like in schizophrenia.
Question 4: Two dizygotic twins present to the university clinic because they believe they are being poisoned through the school's cafeteria food. They have brought these concerns up in the past, but no other students or cafeteria staff support this belief. Both of them are average students with strong and weak subject areas as demonstrated by their course grade-books. They have no known medical conditions and are not known to abuse illicit substances. Which statement best describes the condition these patients have?
A. A trial separation is likely to worsen symptoms.
B. The disorder is its own disease entity in DSM-5.
C. Antipsychotic medications are rarely beneficial.
D. Can affect two or more closely related individuals. (Correct Answer)
E. Cognitive behavioral therapy is a good first-line.
Explanation: ***Can affect two or more closely related individuals.***
- The shared delusional belief in **folie à deux**, also known as **shared psychotic disorder**, typically occurs in two or more people who are closely associated.
- In this case, the **dizygotic twins** sharing the same delusional belief about being poisoned from cafeteria food fits this pattern.
*A trial separation is likely to worsen symptoms.*
- **Separating the individuals** involved in **folie à deux** is often a crucial step in treatment, as it can help break the cycle of shared delusion and allow for individual therapy.
- Separation typically IMPROVES rather than worsens symptoms by removing the reinforcement of the shared delusion.
*The disorder is its own disease entity in DSM-5.*
- In the **DSM-5**, **folie à deux** is no longer considered a separate diagnostic category.
- Instead, it is classified under **Other Specified Schizophrenia Spectrum and Other Psychotic Disorder** or **Unspecified Schizophrenia Spectrum and Other Psychotic Disorder**, with the specific context of shared delusion noted.
*Antipsychotic medications are rarely beneficial.*
- **Antipsychotics** are actually commonly used in treating folie à deux, particularly for the **primary individual** who initially developed the delusion.
- They can be an important component of treatment, often combined with separation and psychotherapy.
*Cognitive behavioral therapy is a good first-line.*
- **Cognitive Behavioral Therapy (CBT)** can be beneficial, particularly after separation, to help individuals challenge and reframe their delusional beliefs.
- However, the **first-line intervention** for shared psychotic disorder is **separation of the involved individuals**, followed by individual therapy (which may include CBT) and medication as needed.
Question 5: A 21-year-old woman is brought by her mother to a psychiatrist due to concerns about her behavior. The patient’s mother tells the psychiatrist that she believes that a famous Hollywood celebrity actor loves her and will marry her. When the patient is asked about this, she says that she attended a function at which this actor was the guest of honor six months back, and he waved his hand at her by which she understood that he loves her. However, when she tries to contact him over the phone, he does not respond, which she says is probably because he is too busy with his career at present. When asked why the successful actor would marry her, she says, “Celebrities often prefer to marry ordinary people and that is why he expressed his interest in me that day”. The patient is otherwise healthy with no known medical condition. She denies any mood disturbances, hallucinations, or anxiety. She is currently working as an assistant manager at a private advertising firm and has a normal socio-occupational life. Which of the following is the most likely diagnosis in this patient?
A. Schizotypal personality disorder
B. Schizophreniform disorder
C. Delusional disorder (Correct Answer)
D. Schizoid personality disorder
E. Schizophrenia
Explanation: ***Delusional disorder***
- The patient exhibits a **non-bizarre delusion** (erotomanic type) that a famous actor is in love with her, which is a key characteristic of delusional disorder.
- She maintains a relatively **normal socio-occupational life** and **lacks other psychotic symptoms** (hallucinations, mood disturbances), which differentiates it from other psychotic disorders.
*Schizotypal personality disorder*
- Characterized by pervasive patterns of **social and interpersonal deficits**, cognitive or perceptual distortions, and eccentricities of behavior.
- While there might be odd beliefs, they don't typically reach the **convictional intensity of a delusion** and are accompanied by social isolation and discomfort.
*Schizophreniform disorder*
- Involves symptoms similar to schizophrenia (hallucinations, delusions, disorganized speech/behavior, negative symptoms) but with a **duration between 1 and 6 months**.
- The patient here only presents with a delusion, **lacks other prominent psychotic symptoms**, and her functionality is preserved, making this unlikely.
*Schizoid personality disorder*
- Defined by a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression in interpersonal settings.
- This patient maintains a **normal socio-occupational life** and her primary issue is a specific delusion, not social withdrawal or emotional flatness.
*Schizophrenia*
- Requires two or more characteristic symptoms (delusions, hallucinations, disorganized speech, disorganized behavior, negative symptoms) for at least **6 months**, with significant impact on functioning.
- This patient's symptoms are limited to a **non-bizarre delusion**, and her **socio-occupational functioning is intact**, ruling out schizophrenia.
Question 6: A 27-year-old man presents to his primary care physician for exposure to toxic materials. The patient states that when he left for work this morning he was certain that he had closed the door to his pantry. However, upon returning home, he saw that the door to his pantry was wide open. The patient is certain that his neighbors have been tampering with his food and potentially poisoned him. He further states that he has known, ever since they have moved in, that they have been trying to break into his house and steal his things. He has tried multiple times to get them evicted from the building to no avail. It is for this reason that he is certain that they are trying to get their revenge upon him. The physician performs a physical exam and tells the patient that he thinks there is nothing to be concerned about, but that he should call him or come into the office if he experiences any symptoms. The patient is outraged at this news and requests a competent doctor who is not colluding with his enemies. He storms out of the office angrily, stating that he deserves the best in medical care, not this. Which of the following is the most likely personality disorder that this patient is suffering from?
A. Intermittent explosive disorder
B. Paranoid personality disorder (Correct Answer)
C. Schizoid personality disorder
D. Narcissistic personality disorder
E. Borderline personality disorder
Explanation: ***Paranoid personality disorder***
- This patient exhibits a pervasive distrust and **suspiciousness of others**, interpreting their motives as malevolent.
- His belief that his neighbors are tampering with his food, trying to break into his house, and that the doctor is colluding with them demonstrates **unwarranted suspicion and paranoid ideation**.
- **Note:** The intensity and fixed nature of these beliefs suggest they may cross into delusional territory, which would indicate **delusional disorder (persecutory type)** rather than a personality disorder. However, among the personality disorder options listed, paranoid personality disorder best fits the presentation of pervasive distrust and suspiciousness.
*Intermittent explosive disorder*
- This disorder is characterized by recurrent **behavioral outbursts** representing a failure to control aggressive impulses.
- While the patient exhibited anger, his primary issue is **pervasive paranoia** rather than episodic impulsive aggression.
*Schizoid personality disorder*
- Individuals with schizoid personality disorder typically display a pervasive pattern of **detachment from social relationships** and a restricted range of emotional expression.
- This patient is actively engaged, albeit negatively, with others and expresses strong emotions, which differs from the emotional aloofness of schizoid personality disorder.
*Narcissistic personality disorder*
- This disorder is characterized by a pervasive pattern of **grandiosity**, a need for admiration, and a lack of empathy; symptoms include sense of entitlement and arrogance.
- While the patient states he \"deserves the best in medical care,\" his primary features are **suspicion and distrust**, not grandiosity or a focus on self-importance.
*Borderline personality disorder*
- This disorder is marked by a pervasive pattern of **instability in interpersonal relationships**, self-image, affects, and impulsivity.
- The patient's presentation lacks the impulsivity, self-harm behaviors, or frantic efforts to avoid abandonment seen in **borderline personality disorder**.
Question 7: A 53-year-old man is brought into the emergency department by ambulance. He was found stumbling in the street. He smells of alcohol and has difficulty answering any questions or giving any history about recent events. He is diagnosed with acute ethanol intoxication. After a night of IV fluid and sleep, he recovers and becomes talkative. He describes an outlandish personal history as a war hero, a movie star, and a famous professor. On physical examination, the patient is malnourished, thin, disheveled, and mildly agitated. He has temporal wasting and conjunctival pallor. Which of the following symptoms would not improve with aggressive therapy including thiamine in this patient?
A. Ophthalmoplegia
B. Delirium tremens
C. Ataxia
D. Anterograde amnesia (Correct Answer)
E. Confusion
Explanation: ***Anterograde amnesia***
- This patient's **confabulation** and **anterograde amnesia** (inability to form new memories) are characteristic of **Korsakoff syndrome**, a chronic and irreversible sequela of Wernicke encephalopathy.
- While prompt thiamine can prevent Wernicke encephalopathy and halt its progression to Korsakoff syndrome, the **amnesia** and **confabulation** of Korsakoff syndrome are often permanent.
*Ophthalmoplegia*
- **Ophthalmoplegia** (eye movement paralysis) is a key component of **Wernicke encephalopathy** and is usually highly responsive to thiamine supplementation.
- Rapid improvement in eye movements is often one of the first signs of effective thiamine therapy in Wernicke encephalopathy.
*Delirium tremens*
- **Delirium tremens** is a severe form of alcohol withdrawal syndrome, distinct from Wernicke encephalopathy, although they can co-exist.
- While thiamine is crucial for Wernicke encephalopathy, delirium tremens is primarily managed with **benzodiazepines**, though thiamine is always given to alcoholics to prevent Wernicke encephalopathy.
*Ataxia*
- **Ataxia** (lack of voluntary coordination of muscle movements) is a hallmark symptom of **Wernicke encephalopathy** and typically improves significantly with high-dose thiamine administration.
- The ataxia in Wernicke encephalopathy is often described as a **wide-based gait** and is due to cerebellar dysfunction.
*Confusion*
- **Acute confusion** or **encephalopathy** is a core component of **Wernicke encephalopathy** and is generally reversible with prompt thiamine treatment.
- The patient's initial inability to provide history and subsequent improvement with IV fluids and sleep (likely containing thiamine) supports this.
Question 8: A 21-year-old college student comes to the physician because of left knee pain. The pain started when he fell off his bike one year ago; since then he has had intermittent stabbing pain and tingling in his knee. The patient says that the pain is caused by a device that was implanted by the US government to control his thoughts and actions. Every time he does something they do not want him to do, the device will send an electromagnetic impulse to his knee. He maintains the device was also responsible for the bicycle accident. Over the past 6 months, it has caused him to hear voices telling him to harm himself or others; he does not listen to these commands because he does not want to “play by their rules.” He has avoided meeting his family and friends since the voices started. He drinks 2 beers a day but does not use illicit drugs. Vital signs are within normal limits. The left knee is nontender and nonerythematous with no swelling. Range of motion is normal. Neurologic examination shows no abnormalities. On mental status examination, the patient appears expressionless. Which of the following is the most appropriate long-term treatment?
A. Valproic acid
B. Quetiapine (Correct Answer)
C. Lithium carbonate
D. Clonidine
E. Midazolam
Explanation: ***Quetiapine***
- This patient presents with **delusions (thought control, implanted device)**, **auditory hallucinations (voices telling him to harm himself or others)**, and **negative symptoms (avoiding family and friends, expressionless affect)**, which are characteristic of **schizophrenia**.
- **Quetiapine** is a **second-generation antipsychotic** (atypical antipsychotic) used for the long-term management of schizophrenia, effectively targeting both positive and negative symptoms.
*Valproic acid*
- **Valproic acid** is primarily a **mood stabilizer** and **anticonvulsant**.
- It is used in conditions like **bipolar disorder** or **epilepsy**, not as a first-line long-term treatment for schizophrenia.
*Lithium carbonate*
- **Lithium carbonate** is a **mood stabilizer** predominantly used for **bipolar disorder**.
- It is not indicated for the primary long-term treatment of psychotic disorders like schizophrenia.
*Clonidine*
- **Clonidine** is an **alpha-2 adrenergic agonist** used for conditions like **hypertension**, **ADHD**, or **withdrawal symptoms**.
- It has no role in the long-term management of schizophrenia or psychotic symptoms.
*Midazolam*
- **Midazolam** is a **short-acting benzodiazepine** used for **acute sedation**, **anxiety**, or **seizures**.
- It is not a long-term treatment for psychotic disorders and carries risks of dependence and tolerance with prolonged use.
Question 9: A 35-year-old woman is brought to the inpatient psychiatric unit by the police after she was found violating the conditions of her restraining order by parking on the side street of her "lover’s" home every night for the past week. Her "lover", a famous hometown celebrity, has adamantly denied any relationship with the patient over the past 6 months. The patient insists that ever since he signed a copy of his album at a local signing, she knew they were in love. Despite him having his own wife and children, the patient insists that he is in love with her and goes to his house to meet in secret. Physical examination of the patient is unremarkable. Urine toxicology is negative. Which of the following statements best describes this patient’s condition?
A. The patient will have concurrent psychotic disorders.
B. The disorder must meet 2 out of the 5 core criteria.
C. Symptoms must be present for at least 4 weeks. (Correct Answer)
D. This disorder has a high prevalence rate.
E. Patients may have a contributing medical condition.
Explanation: ***Symptoms must be present for at least 4 weeks.***
- This patient presents with symptoms highly suggestive of **delusional disorder, erotomanic type**, where the primary delusion is that another person, usually of higher status, is in love with them. For a diagnosis of delusional disorder, the DSM-5 criteria state that the presence of one or more delusions must persist for **at least 1 month**.
- The patient's unwavering belief in a secret relationship with a celebrity, despite clear evidence to the contrary and the celebrity's denial, aligns with the characteristics of a **fixed, nonbizarre delusion**, which is the hallmark of delusional disorder.
*The patient will have concurrent psychotic disorders.*
- In **delusional disorder**, by definition, the patient typically does **not experience other psychotic symptoms** like prominent hallucinations, disorganized speech, or grossly disorganized/catatonic behavior.
- If other psychotic symptoms are prominent, the diagnosis would likely shift to **schizophrenia** or **schizoaffective disorder**, not delusional disorder.
*The disorder must meet 2 out of the 5 core criteria.*
- This statement refers to the diagnostic criteria for **schizophrenia**, which requires two or more of the five core symptoms (delusions, hallucinations, disorganized speech, grossly disorganized/catatonic behavior, negative symptoms).
- Delusional disorder is characterized primarily by the presence of **nonbizarre delusions** without meeting the full criteria for schizophrenia.
*This disorder has a high prevalence rate.*
- **Delusional disorder** is relatively **uncommon**, with an estimated lifetime prevalence of about 0.2%.
- It is one of the **less common psychotic disorders**, especially when compared to schizophrenia or mood disorders with psychotic features.
*Patients may have a contributing medical condition.*
- While medical conditions can sometimes cause psychotic symptoms (e.g., **substance-induced psychosis** or psychosis due to another medical condition), this is typically excluded in the diagnosis of **primary delusional disorder**.
- The patient's urine toxicology is negative, and her physical examination is unremarkable, suggesting that her symptoms are not due to a medical condition or substance use.
Question 10: A 46-year-old woman presents to a psychiatrist for evaluation. Three months prior, the patient moved to a new apartment building, and since then, she has become increasingly convinced that her doorman has been stealing her packages and going into her apartment while she is not home. She states that objects do not stay where she leaves them, and sometimes she expects mail but never receives it. She has filed numerous complaints with her leasing company. The building has 24-hour security footage, however, which has never shown any other person entering her apartment. On further questioning, the patient denies audiovisual hallucinations or changes in sleep, mood, energy levels, or eating. The family reports that her behavior and affect have not changed. The patient works as a pharmacist. She has no psychiatric history, although her father had a history of major depressive disorder. Which of the following is the likely diagnosis?
A. Adjustment disorder
B. Paranoid personality disorder
C. Narcissistic personality disorder
D. Delusional disorder (Correct Answer)
E. Schizotypal personality disorder
Explanation: ***Delusional disorder***
- The patient exhibits **non-bizarre delusions** (belief that her doorman is stealing packages and entering her apartment) for **>1 month** (3 months in this case).
- She maintains her **normal functioning** (works as a pharmacist), with **no marked impairment** in behavior or affect, and **no other psychotic symptoms** (no hallucinations, disorganized speech, or negative symptoms).
- **Key diagnostic feature**: Fixed, false beliefs that persist despite evidence to the contrary (security footage), but behavior is not obviously bizarre or odd outside the delusional content.
- This distinguishes delusional disorder from schizophrenia, which requires additional psychotic symptoms.
*Adjustment disorder*
- This disorder is characterized by **emotional or behavioral symptoms** developing within 3 months of an identifiable stressor (moving to new apartment).
- However, her symptoms are **fixed, false beliefs (delusions)** rather than an emotional/behavioral adaptation response to stress.
- Adjustment disorder does not involve psychotic symptoms like delusions.
*Paranoid personality disorder*
- This is a **personality disorder** characterized by a **pervasive, lifelong pattern** of distrust and suspiciousness beginning by early adulthood.
- The patient's symptoms are **acute onset** (3 months ago after moving), not lifelong, and involve **fixed delusions** rather than pervasive personality traits.
- In paranoid personality disorder, beliefs are suspicious but **not delusional** (not fixed, false beliefs held with absolute conviction).
*Narcissistic personality disorder*
- This disorder is characterized by a **pervasive pattern of grandiosity**, need for admiration, and lack of empathy.
- There is no evidence in the vignette to suggest traits of grandiosity, entitlement, or self-importance.
- This diagnosis is not supported by the clinical presentation.
*Schizotypal personality disorder*
- This disorder involves a pervasive pattern of **social and interpersonal deficits**, **odd beliefs** (magical thinking, ideas of reference), unusual perceptual experiences, and eccentricities of behavior.
- The patient does not exhibit the characteristic features: **no odd/eccentric behavior**, no magical thinking, no unusual perceptual experiences, and **maintains normal social/occupational functioning**.
- Her beliefs are true delusions (fixed, false) rather than odd beliefs or suspiciousness.
Question 11: A 24-year-old male graduate student comes to the physician for a two-month history of repeated thoughts and anxiety that he is going to be harmed by someone on the street. The anxiety worsened after witnessing a pedestrian getting hit by a car two weeks ago. He says, “That was a warning sign.” On his way to school, he now often leaves an hour earlier to take a detour and hide from people that he thinks might hurt him. He is burdened by his coursework and fears that his professors are meaning to fail him. He says his friends are concerned about him but that they do not understand because they were not present at the accident. The patient has no known history of psychiatric illness. On mental status exam, he is alert and oriented, and shows full range of affect. Thought processes and speech are organized. His memory and attention are within normal limits. He denies auditory, visual, or tactile hallucinations. Urine toxicology screening is negative. Which of the following is the most likely diagnosis in this patient?
A. Avoidant personality disorder
B. Schizotypal personality disorder
C. Delusional disorder (Correct Answer)
D. Generalized anxiety disorder
E. Acute stress disorder
Explanation: ***Delusional disorder***
- This patient presents with **persistent non-bizarre delusions** (fear of harm, professors failing him) that have lasted for two months. His functioning is largely intact outside of the delusions, and there are no prominent hallucinations or disorganized thought. The anxiety and behavioral changes (detouring, hiding) are consequences of his delusions.
- The patient's belief that his friends *do not understand* because they were not present at the accident suggests he is trying to rationalize his beliefs and behaviors within his delusional system, which is characteristic of delusional disorder where insight into the delusion is typically absent.
*Avoidant personality disorder*
- Characterized by **social inhibition**, feelings of inadequacy, and **hypersensitivity to negative evaluation**.
- While there is some social withdrawal (hiding from people), his primary motivation is a fear of harm based on fixed beliefs, not a fear of social rejection or embarrassment.
*Schizotypal personality disorder*
- Involves a pervasive pattern of **social and interpersonal deficits** marked by acute discomfort with, and reduced capacity for, close relationships, as well as by **cognitive or perceptual distortions** and eccentricities of behavior.
- This patient does not exhibit the characteristic odd beliefs, magical thinking, unusual perceptual experiences, or eccentric behavior typically seen in schizotypal personality disorder. His thought process is organized, and he denies hallucinations.
*Generalized anxiety disorder*
- Defined by **excessive and uncontrollable worry** about multiple events or activities, often accompanied by physical symptoms like restlessness, fatigue, and muscle tension.
- While the patient experiences anxiety, it is primarily driven by specific, fixed beliefs (delusions) rather than generalized, free-floating worry.
*Acute stress disorder*
- Occurs within **one month of exposure to a traumatic event** and involves dissociative symptoms, intrusion symptoms, negative mood, avoidance symptoms, and arousal symptoms.
- Although he witnessed a traumatic event, the primary features are persistent, non-bizarre delusions rather than a constellation of acute stress symptoms and dissociation. The timeline also extends beyond the typical 1-month duration for acute stress disorder.
Question 12: A 46-year-old homeless man was found wandering aimlessly in the supermarket. On examination, he is confused and said that the President appointed men to kill him because he is disclosing state secrets to extraterrestrial organisms. The man also has horizontal nystagmus and an ataxic gait. What is the most likely cause of the clinical presentation?
A. Neurofibrillary tangles
B. Atrophy of globus pallidus
C. Necrosis of mammillary bodies (Correct Answer)
D. Hypothyroidism
E. Trinucleotide repeat disorder
Explanation: ***Necrosis of mammillary bodies***
- The patient's presentation with confusion, delusions (President appointing men to kill him), horizontal nystagmus, and ataxic gait is highly suggestive of **Wernicke-Korsakoff syndrome**, which is primarily caused by **thiamine (B1) deficiency**.
- **Necrosis of the mammillary bodies** is a classic neuropathological hallmark of Wernicke-Korsakoff syndrome, due to their high metabolic rate and vulnerability to thiamine deficiency.
*Neurofibrillary tangles*
- **Neurofibrillary tangles**, composed of hyperphosphorylated tau protein, are characteristic of **Alzheimer's disease** and other tauopathies.
- While Alzheimer's can cause confusion and disorientation, it typically does not present with acute nystagmus and ataxia in this manner, and delusions are usually less bizarre.
*Atrophy of globus pallidus*
- **Atrophy of the globus pallidus** can be seen in various neurodegenerative disorders, including some forms of **Huntington's disease** or mitochondrial disorders.
- However, it is not a primary or characteristic finding for Wernicke-Korsakoff syndrome or the specific acute constellation of symptoms presented.
*Hypothyroidism*
- **Hypothyroidism** can cause confusion, cognitive slowing, and sometimes ataxia (due to cerebellar dysfunction).
- However, it typically does not cause acute horizontal nystagmus or the distinct, florid psychotic delusions described.
*Trinucleotide repeat disorder*
- **Trinucleotide repeat disorders** (e.g., Huntington's disease, spinocerebellar ataxias) are genetic conditions that cause various neurological symptoms, including cognitive decline, movement disorders, and psychiatric features.
- These are typically chronic, progressive conditions and do not present acutely with the specific triad of nystagmus, ataxia, and confusion/psychosis seen in thiamine deficiency.
Question 13: A 38-year-old woman comes to the physician for a 6-week history of sleeping difficulties because she thinks that someone is watching her through security cameras. Her anxiety started 6 weeks ago when a security camera was installed outside her house by the police. Ever since, she has felt that she is being monitored by security cameras throughout the city. She avoids going outside whenever possible and refuses to take the subway. Whenever she needs to leave the house she wears large hats or hooded sweaters so that she cannot be recognized by the cameras. As soon as she arrives at her office or at home she feels safer. She was recently promoted to the team manager of a small advertising agency. She takes no medications. On mental status examination, she is alert, oriented, and shows normal range of affect. Urine toxicology screening is negative. The patient's symptoms are best described as which of the following?
A. Hallucinations
B. Delusions (Correct Answer)
C. Agoraphobia
D. Derealization
E. Disorganized thoughts
Explanation: ***Delusions***
- The patient exhibits strong, false beliefs (**fixed beliefs**) that she is being watched through security cameras, despite evidence to the contrary and the unlikelihood of such widespread monitoring.
- These beliefs are **persecutory** in nature, causing significant distress and impacting her daily functioning (e.g., avoiding public places, wearing concealing clothing).
*Hallucinations*
- Hallucinations are **sensory perceptions** in the absence of an external stimulus (e.g., hearing voices, seeing things that aren't there).
- The patient *believes* she is being watched but does not *perceive* visual or auditory confirmation of this monitoring.
*Agoraphobia*
- Agoraphobia is an **anxiety disorder** characterized by intense fear and avoidance of situations or places where escape might be difficult or help unavailable if panic symptoms occur.
- While she avoids going outside, her avoidance stems from a specific belief about being watched, not a general fear of public spaces or panic attacks.
*Derealization*
- Derealization is a dissociative symptom where an individual feels that the **external world is unreal** or distant.
- The patient's perception of reality is altered by her belief, but she does not feel the world itself is unreal; rather, she believes a specific, false scenario is occurring within it.
*Disorganized thoughts*
- Disorganized thoughts manifest as **incoherent speech**, thought blocking, or illogical associations, making it difficult to follow a conversation.
- Her thought process is coherent and goal-directed, even though the content of her thoughts is delusional.
Question 14: A 22-year-old man is brought to the emergency department by his father because he is having bizarre thoughts. The patient says that he is being haunted by aliens from outer space. The father is worried as his son has had these symptoms for the past 7 months and lately, it seems to be getting worse. He has become more self-obsessed and does not seem to have any interest in his favorite activities. He has no plans to harm himself or others but spends a lot of time and energy building ‘defenses’ in and around his room as he is absolutely sure that aliens will come to get him soon. His blood pressure is 121/79 mm Hg, pulse 86/min, respiratory rate 15/min, temperature 36.8°C (98.2°F). Which of the following is correct regarding the patient’s symptoms?
A. It would benefit from psychosurgery.
B. He has a fixed false belief. (Correct Answer)
C. It is best treated with cognitive behavioral therapy alone.
D. It is a negative symptom.
E. It falls under the disorganized thinking domain.
Explanation: ***He has a fixed false belief.***
- The patient's conviction that he is being haunted by aliens, despite evidence to the contrary and the distress it causes, constitutes a **delusion**.
- A delusion is by definition a **fixed, false belief** that is not in keeping with the individual's cultural background.
*It would benefit from psychosurgery.*
- Psychosurgery, such as lobotomy, is an extreme and rarely used intervention for **severe, refractory mental disorders**, typically only after all other treatments have failed and with significant ethical considerations.
- While the patient's symptoms are impairing, **first-line treatments** for psychotic disorders involve antipsychotic medications and psychotherapy, not psychosurgery.
*It is best treated with cognitive behavioral therapy alone.*
- While CBT for psychosis (CBTp) can be a useful **adjunct** in managing delusions and reducing distress, it is **not sufficient as monotherapy** for active, severe psychotic symptoms.
- The primary intervention for profound delusions like those described is **antipsychotic medication**, with CBT added as an adjunctive treatment to help improve functioning and coping.
- CBT alone would be inadequate for someone with such fixed, impairing delusions actively building defenses against perceived threats.
*It is a negative symptom.*
- Negative symptoms of psychosis include features like **anhedonia** (lack of pleasure), **alogia** (poverty of speech), **avolition** (lack of motivation), and affective flattening.
- The patient's bizarre belief in aliens is a **positive symptom** as it represents an *addition* to normal experience, rather than a *reduction* or *absence* of normal functions.
- Note: The patient's decreased interest in activities suggests negative symptoms are also present, but the question asks about "the patient's symptoms" in context of the delusion described.
*It falls under the disorganized thinking domain.*
- Disorganized thinking or speech involves patterns like **loose associations, tangentiality, incoherence**, or word salad, where the logical connections between thoughts are lost.
- While the content of the patient's thoughts is bizarre, the core issue described is the *belief itself* (a delusion, which is a **positive symptom**), rather than disordered *thought processes* or the way he expresses them.
Question 15: A 33-year-old man is brought to the emergency department by his mother because of erratic behavior over the past 6 months. He spends most of his time alone in his room because he believes he is being followed by the Secret Service. He was fired from his job 3 months ago after threatening a colleague. He appears suspicious of his surroundings and asks the doctor questions about “the security of the hospital.” The patient exhibits a flat affect. During physical examination, he tells the doctor that he has a gun at home and plans to shoot his neighbor, whom he thinks is working for the Secret Service. Which of the following is the most appropriate action by the doctor?
A. Request a court order to override the patient's right to confidentiality
B. Discuss the diagnosis and therapy plan with the patient's mother
C. Inform security and law enforcement
D. Administer haloperidol and request a psychiatric consultation
E. Warn the person at risk and inform law enforcement (Correct Answer)
Explanation: ***Warn the person at risk and inform law enforcement***
- This is the most appropriate action due to the **Tarasoff duty**, which mandates that a therapist must warn an identifiable victim if a patient expresses a serious threat of physical violence against them.
- The patient has expressed a clear intent to harm his neighbor, identifying the victim and providing a means (a gun), necessitating intervention to protect the potential victim and involve law enforcement.
*Request a court order to override the patient's right to confidentiality*
- While patient confidentiality is important, the **Tarasoff duty** creates an exception when there is a serious and immediate threat of harm to others, overriding the need for a court order in such urgent situations.
- Delaying action by seeking a court order could compromise the safety of the identified potential victim.
*Discuss the diagnosis and therapy plan with the patient's mother*
- The patient's mother is not the identified victim, and while she may be concerned, discussing the diagnosis and therapy plan with her would still violate the patient's **confidentiality** without proper consent or a specific legal exception related to her safety.
- The primary concern here is the safety of the identified potential victim, not managing the patient's care through his mother at this immediate juncture.
*Inform security and law enforcement*
- While informing security and law enforcement is a necessary step, it is not sufficient on its own according to the **Tarasoff duty**, which also requires directly warning the potential victim.
- The "duty to warn" the intended victim directly is a critical component of preventing harm, in addition to involving official authorities.
*Administer haloperidol and request a psychiatric consultation*
- Administering medication and requesting a psychiatric consultation are important steps for managing the patient's **psychosis** and overall care.
- However, these actions alone do not fulfill the immediate ethical and legal obligation to warn the identified potential victim of the imminent threat.