Autonomic/CV Drugs — MCQs

A 77-year-old woman with congestive heart failure is admitted to the hospital for evaluation prior to cardiac transplantation. During her stay at the hospital, the physician prescribes a drug to improve cardiac contractility. The drug works by selectively inhibiting an isoenzyme that is responsible for the degradation of cyclic adenosine monophosphate. Which of the following is the most likely adverse effect of this drug?

A 20-year-old girl presents to a physician following unprotected coitus with her boyfriend about 10 hours ago. She tells the doctor that although they usually use a barrier method of contraception, this time they forgot. She does not want to become pregnant. She also mentions that she has major depression and does not want to take an estrogen-containing pill. After necessary counseling, the physician prescribes an enteric-coated pill containing 1.5 mg of levonorgestrel. Which of the following is the primary mechanism of action of this drug?

A 55-year-old man is discharged from the hospital after being treated for a ST-elevation myocardial infarction. The patient became hypotensive to 87/48 mmHg with a pulse of 130/min. He was properly resuscitated, and a cardiac catheterization with stent placement was performed. Upon being discharged, the patient was started on metoprolol, lisinopril, aspirin, atorvastatin, and nitroglycerin. Upon presentation to the patient’s primary care doctor today, his liver enzymes are elevated with an AST of 55 U/L and an ALT of 57 U/L. Which of the following is the most likely etiology of these laboratory abnormalities?

A 45-year-old man undergoes an esophagogastroduodenoscopy for his recurrent episodes of epigastric pain. He also lost a significant amount of weight in the last 6 months. He says that he has been taking a number of dietary supplements "to cope". His past medical history is insignificant, and a physical examination is within normal limits. The endoscopy shows a bleeding ulcer in the proximal duodenum. Lab tests reveal a serum iron level of 130 μg/dL. However, his stool guaiac test is negative for occult blood. Over-ingestion of which of the following substances is the most likely cause for this patient’s lab findings?

A 28-year-old man makes an appointment with his general practitioner for a regular check-up. He has recently been diagnosed with asthma and was given a short-acting β2-agonist to use during acute exacerbations. He said he usually uses the medication 1–2 times per week. Which of the following is the most appropriate treatment in this case?

A 48-year-old woman visits the clinic with unintentional weight loss for the past 3 months. She is also concerned about difficulty swallowing solid food. She also has early satiety and mild abdominal discomfort. An upper gastrointestinal endoscopy is advised along with a biopsy. The histopathological report reveals gastric adenocarcinoma. She then undergoes a subtotal gastrectomy and is started on an adjuvant chemotherapy regimen with platinum and fluoropyrimidine. 2 weeks later she develops acute respiratory distress and chest pain. A D-dimer test is positive. Her blood pressure is 125/78, heart rate is 110/min, and oxygen saturation is 88%. CT scan of the chest reveals a clot in the anterior segmental artery in the right upper lung. Which of the following therapies should the patient be started on for her acute condition?

A 57-year-old man comes to the physician because of a 4-week history of constipation, episodic bloody stools, progressive fatigue, and a 5-kg (10.2-lb) weight loss. Digital rectal examination shows a hard, 1.5-cm rectal mass. A biopsy confirms the diagnosis of colorectal carcinoma. The patient begins treatment with a combination chemotherapy regimen that includes a drug that is also used in the treatment of wet age-related macular degeneration. This drug most likely acts by inhibiting which of the following substances?

A 56-year-old postmenopausal woman comes to the physician because of a 6-month history of worsening pain and swelling in her left knee. She has a history of peptic ulcer disease for which she takes cimetidine. Examination shows palpable crepitus and limited range of motion of the left knee. Which of the following is the most appropriate pharmacotherapy for this patient’s symptoms?

A 45-year-old man presents with a persistent cough for the past month. He says it started off with a runny nose and fever, from which he recovered in a week, but he says that the cough persists after the resolution of the fever. The patient denies any expectoration, chest pain, weight loss, or breathlessness. He reports no history of recent travel or sick contacts. Past medical history is significant for chronic constipation. He reports a 15-pack-year smoking history but denies any alcohol or current recreational drug use. He says he did use intravenous drugs in his late twenties but quit after going through a drug rehabilitation program. Physical examination is unremarkable. Laboratory findings and a chest radiograph are normal. Which of the following would be the best choice as a cough suppressant in this patient?

A 65-year-old man presents to the emergency department with shortness of breath. He was at home cleaning his yard when his symptoms began. The patient is a farmer and does not have regular medical care. He has smoked two packs of cigarettes every day for the past 40 years. The patient lives alone and admits to feeling lonely at times. His temperature is 99.5°F (37.5°C), blood pressure is 159/95 mmHg, pulse is 90/min, respirations are 19/min, and oxygen saturation is 86% on room air. On physical exam, you note a man in distress. Pulmonary exam reveals poor air movement, wheezing, and bibasilar crackles. Cardiac exam is notable for an S4 heart sound. The patient is started on appropriate therapy and his symptoms improve. Prior to discharge he is no longer distressed when breathing and his oxygen saturation is 90% on room air. Which of the following interventions could improve mortality the most in this patient?