Question 1

Question

A 38-year-old woman with type 1 diabetes for 20 years presents with diabetic ketoacidosis. She is treated and recovers. Six months later, she develops progressive fatigue, nausea, and hyperpigmentation. Laboratory studies show morning cortisol 3 μg/dL, ACTH 180 pg/mL, TSH 8.2 mIU/L, free T4 0.6 ng/dL, and positive anti-thyroid peroxidase antibodies. She also has positive 21-hydroxylase antibodies. Her 12-year-old daughter was recently diagnosed with type 1 diabetes. Evaluate the pathologic process and most critical monitoring recommendation for the daughter.

Accepted Answer

Autoimmune polyglandular syndrome type 2; screen daughter for adrenal antibodies and thyroid function annually

Answer

Multiple endocrine neoplasia syndrome; screen for pheochromocytoma and medullary thyroid cancer

Answer

Schmidt syndrome with isolated sporatic occurrence; routine diabetes management only for daughter

Answer

Autoimmune polyglandular syndrome type 1; screen for mucocutaneous candidiasis and hypoparathyroidism

Answer

Secondary endocrine failure from diabetes complications; optimize glycemic control in daughter

Endocrine pathology — MCQs

Endocrine pathology — MCQs

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