Question 1

Question

A 55-year-old man with a long history of alcohol use disorder presents with jaundice, tender hepatomegaly, and fever. A liver biopsy is performed. The biopsy demonstrates hepatocytes containing irregular rope-like eosinophilic cytoplasmic inclusions, ballooning degeneration of hepatocytes, neutrophilic infiltration predominantly in zone 3 (centrilobular region), and scattered acidophil bodies. Which of the following best identifies the cytoplasmic inclusions depicted and their composition?

Accepted Answer

Mallory-Denk bodies composed of aggregated ubiquitinated cytokeratin 8 and cytokeratin 18 intermediate filaments

Answer

Councilman bodies composed of condensed apoptotic nuclear chromatin and cytoplasmic remnants

Answer

Ground-glass inclusions composed of accumulated hepatitis B surface antigen within the endoplasmic reticulum

Answer

Lafora bodies composed of polyglucosan deposits derived from abnormal glycogen branching

Answer

Alpha-1-antitrypsin globules composed of misfolded glycoprotein retained within the rough endoplasmic reticulum

Cell injury — MCQs

Cell injury — MCQs

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